DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment smid and Atad3a

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	NP_849534.2	Gene:	Atad3a / 108888	MGIID:	1919214	Length:	591	Species:	Mus musculus

Alignment Length:	612	Identity:	122/612 - (19%)
Similarity:	216/612 - (35%)	Gaps:	183/612 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   403 DP-GLRRIGRFDHEIAIHIPSRKERREILRIQCEGLSVDPKLNYDKIAELTPGYVGADLMALVSR 466
            || ||.|..:...|:. |....||...:.::|.:.|.::.:   .|:.|.
Mouse    50 DPTGLERAAKAARELE-HSRHAKEALSLAQMQEQTLQLEQQ---SKLKEY--------------- 95

  Fly   467 AASVAVKRRSMKKFRELHAASEKNMTTVTLDDDEPSEDAGETPVPDSKGEETAKDAEAEQKVDGD 531
              ..||::   .|..::...:|:...|:|   :|..:........|....:..:|...:|::..:
Mouse    96 --EAAVEQ---LKSEQIRVQAEERRKTLT---EETRQHQARAQYQDKLARQRYEDQLKQQQLLNE 152

  Fly   532 KETSAKDKSEGDSPNIETPKKAT-NGNSSIKSPQKTPKKSAEKPTDAAMDVDN--VAPEEPK-KA 592
            :...   |.|......|..::|| .....::...:..:..||....|..|.:|  :..|:.: ||
Mouse   153 ENLR---KQEESVQKQEAIRRATVEREMELRHKNEMLRVEAEARARAKADRENADIIREQIRLKA 214

  Fly   593 VEQEVDSSSSNDEYYEPTLAELTNFLDNPPEEFADPNFCLTLIDFVDAIKVMQPSAKREGFITVP 657
            .|            :..|:.|......             ||:.              |||....
Mouse   215 AE------------HRQTILESIRTAG-------------TLLG--------------EGFRAFV 240

  Fly   658 DTTWDDI--------------------------------GALEKIREELKLAVLAPVKYPEMLER 690
             |.||.:                                |....:||..:::||..:::|..:.|
Mouse   241 -TDWDKVTATVAGLTLLAVGVYSAKNATSVAGRYIEARLGKPSLVRETSRISVLEALRHPIQVSR 304

  Fly   691 LGLTAPS----------------------------------GVLLCGPPGCGKTLLAKAIANEAG 721
            ..::.|.                                  .||:.||||.||||.||.:|..:|
Mouse   305 RLVSRPQDALEGVILSPSLEARVRDIAIATRNTKKNKSLYRNVLMYGPPGTGKTLFAKKLALHSG 369

  Fly   722 INFISVKGPELMNMYVG-ESERAVRACFQRARNS-APCVIFFDEFDSLCPKRSDGGDGNNSGTRI 784
            :::..:.|.::..|  | |...|:...|..|..| ...::|.||.|:...||:.        .:|
Mouse   370 MDYAIMTGGDVAPM--GREGVTAMHKVFDWASTSRRGLLLFVDEADAFLRKRAT--------EKI 424

  Fly   785 VNQLLTEMDGVEERKGVY-----ILAATNRPDIIDPAILRPGRLDTILYVGFPEQSERTE----- 839
            ...|...::....|.|.:     ::.|:|:|:..|.||  ..|:|.::....|::.||..
Mouse   425 SEDLRATLNAFLHRTGQHSSKFMLVLASNQPEQFDWAI--NDRIDEMVCFALPQREERERLVRMY 487

  Fly   840 ----ILKATTKNGKRPVLADDVD----LDEIAAQTEGYTGADLAGLVK--QASMFS-----LRQS 889
                :||..|: ||:.:.....|    ..|:|..|||.:|.::|.|..  ||..:|     |.::
Mouse   488 FDKYVLKPATE-GKQRLKVAQFDYGKKCSEVAQLTEGMSGREIAQLAVAWQAMAYSSEDGVLTEA 551

  Fly   890 LNNGDTNLDDLCVRSQHFQEALQQLRP 916
            :.  |..:.|...:.|...:.|:..||
Mouse   552 MM--DARVQDAVQQHQQKMQWLKVERP 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330
		SpoVK	271..919	CDD:223540	122/612 (20%)
		AAA	287..418	CDD:278434	6/15 (40%)
		P-loop_NTPase	679..>716	CDD:304359	16/70 (23%)
		AAA	699..830	CDD:278434	40/137 (29%)
Atad3a	NP_849534.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52		1/1 (100%)
		Required for interaction with the inner surface of the mitochondrial outer membrane. /evidence=ECO:0000250	2..49
		DUF3523	42..285	CDD:288859	48/304 (16%)
		S100B-binding. /evidence=ECO:0000250	289..304		3/14 (21%)
		AAA	347..472	CDD:278434	40/136 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	572..591		2/5 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910