Protein Alignment smid and afg2a

DIOPT Version :10

• Sequence 1: NP_523959.2
• Gene: smid / 38824
• FlyBaseID: FBgn0016983
• Length: 944
• Species: Drosophila melanogaster
• Sequence 2: XP_004911173.2
• Gene: afg2a / 100494828
• XenbaseID: XB-GENE-6054426
• Length: 872
• Species: Xenopus tropicalis
• Alignment Length: 887
• Identity: 266/887 - (29%)
• Similarity: 411/887 - (46%)
• Gaps: 228/887 - (25%)

  Fly    65 ISESYNLDKVSSSEEDCVSEDSEPPPTNSVMNN--MMNSLYSQPRKPLAPKPISEPIDISSGDEN 127
            :.||  |.:.||..|..:...|....|:.:..|  |:|              |.|.:
 Frog   189 VQES--LQRTSSENELTLERTSLDTSTSDISLNLSMLN--------------IEESL-------- 229

  Fly   128 EDDSNTKTT------NGDGVAAAAAPPPPTPAVQGSALKRLMEEVPEIAVAAKKVAKPNTIHVSS 186
               |||.:|      .||.|       |.|..|..:..|.  :...|:..........:....|.
 Frog   230 ---SNTTSTPSRSNEYGDSV-------PRTGVVCETPTKD--QNSGELGQECSDCLSTDNNDRSE 282

  Fly   187 SEAIQKLHQVVGNRA-KNLSEDAVPRSKDHRNVPGLYQQLHQNQSRDRLRKFKRDLEVQHPTESF 250
            .|.:...|...|.|. |:......|::|    :....|:....:..|.|::          ..::
 Frog   283 KENLTSPHSRAGARCNKDTYYCISPQTK----ITYKEQKTTTAKETDELKR----------KVTY 333

  Fly   251 RDIGGMDSTLKELCEML-IHIKSPEFYFQLGLLPSRGLLLHGPPGCGKTFLARAISGQLKMPLME 314
            ..|||:.:.|||:.|.: :.:|.||.:...|:.|.||:||:||||.|||.:||||:.::...:..
 Frog   334 NMIGGLKAELKEIRETIELPLKQPELFRNYGIPPPRGVLLYGPPGTGKTLIARAIANEVGAHVTV 398

  Fly   315 IPATELIGGISGESEERIREVFDQAIGYSPCVLFIDEIDAIGGNRQWASKDMERRIVSQLISSLD 379
            |...|::....||||.|:|::|..|....|.::||||:||:...|:.|..::|:|:|:.|::.:|
 Frog   399 INGPEIVSKFYGESEARLRQIFADASQCCPSIIFIDELDALCPKREGAQNEVEKRVVASLLTLMD 463

  Fly   380 NLKANEFGQSVVVIAATTRPDVLDPGLRRIGRFDHEIAIHIPSRKERREIL---------RIQCE 435
            .:.:.|....::|:.||.||..|||.|||.||||.||.|.:|:.:.|.:||         |::.|
 Frog   464 GIGSEESQGQLLVLGATNRPHSLDPALRRPGRFDKEIEIGVPNAQGRLDILQKVLKKVPHRLKEE 528

  Fly   436 GLSVDPKLNYDKIAELTPGYVGADLMALVSRAASVAVKRRSMKKFRELHAASEKNMTTVTLDDDE 500
            .|:        ::|:.|.|||||||.||...|...|::|    ..|.|...|::.|
 Frog   529 DLA--------QLADRTHGYVGADLAALCKEAGMNALRR----THRVLSRPSDREM--------- 572

  Fly   501 PSEDAGETPVPDSKGEETAKDAEAEQKVDGDKETSAKDKSEGDSPNIETPKKATNGNSSIKSPQK 565
                ||
 Frog   573 ----AG----------------------------------------------------------- 574

  Fly   566 TPKKSAEKPTDAAMDVDNVAPEEPKKAVEQEVDSSSSNDEYYEPTLAELTNFLDNPPEEFADPNF 630
                                                                           :.
 Frog   575 ---------------------------------------------------------------SV 576

  Fly   631 CLTLIDFVDAIKVMQPSAKREGFITVPDTTWDDIGALEKIREELKLAVLAPVKYPEMLERLGLTA 695
            .:||.||:.|...::|||.||..|.||:.:|.|||.||.::.:||.||..|:.:|:...|:|:..
 Frog   577 VITLNDFLQATNEVRPSAMREVAIDVPNVSWSDIGGLENVKLKLKQAVEWPLMHPDSFIRMGIQP 641

  Fly   696 PSGVLLCGPPGCGKTLLAKAIANEAGINFISVKGPELMNMYVGESERAVRACFQRARNSAPCVIF 760
            |.||||.|||||.||::|||:|||:|:||::||||||||.||||||||||..|.:||..||.::|
 Frog   642 PKGVLLYGPPGCSKTMIAKALANESGLNFLAVKGPELMNKYVGESERAVREIFHKARAVAPSILF 706

  Fly   761 FDEFDSLCPKRSDGGDGNNSGTRIVNQLLTEMDGVEERKGVYILAATNRPDIIDPAILRPGRLDT 825
            |||.|:|..:|  |....:...|::.||||||||:|:.|.|.|||||||||:||.|::||||:|.
 Frog   707 FDEIDALAIER--GSSAGSVADRVLAQLLTEMDGIEQLKDVVILAATNRPDLIDKALMRPGRIDR 769

  Fly   826 ILYVGFPEQSERTEILKATTKNGKRPVLADDVDLDEIAAQTEGYTGADLAGLVKQASMFSLRQSL 890
            |:||..|:.:.|.||.|  .:....|: :.::.|:::..|||.|:||::..:.::|::.:|.:
 Frog   770 IIYVPLPDAATRREIFK--LRFHSMPI-STEICLEKLVEQTEKYSGAEITAVCREAALLALEE-- 829

  Fly   891 NNGDTNLDDLCVRSQHFQEALQQLRPSVNEQDRKIYDKLRLK 932
                 ::....:..:||::||..:.|.:.:...:.|::.:.|
 Frog   830 -----DIQAEFIMGRHFEKALAIVTPRIPDSLIQFYERYQEK 866

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:465247	2/5 (40%)
		CDC48	<242..933	CDD:273521	230/701 (33%)
afg2a	XP_004911173.2	CDC48	<309..868	CDD:273521	234/731 (32%)