Protein Alignment SMSr and SGMS1

DIOPT Version :10

• Sequence 1: NP_648114.1
• Gene: SMSr / 38823
• FlyBaseID: FBgn0052380
• Length: 600
• Species: Drosophila melanogaster
• Sequence 2: NP_671512.1
• Gene: SGMS1 / 259230
• HGNCID: 29799
• Length: 413
• Species: Homo sapiens
• Alignment Length: 448
• Identity: 150/448 - (33%)
• Similarity: 222/448 - (49%)
• Gaps: 107/448 - (23%)

  Fly    52 PLLVAQWSIEN-VTSWATCMEHFSRTLLDCLRQEAIDGEVLLSLTEEDVR--------------- 100
            |..||.|.:|| :..:...:|||:             |:.|::||:||.:
Human     9 PKKVADWLLENAMPEYCEPLEHFT-------------GQDLINLTQEDFKKPPLCRVSSDNGQRL 60

  Fly   101 -DMRYKLGYKLTFGELKKFWIAVLKLQLLVKNSSAESVILGIECHGNGNS---------VYMPLA 155
             ||                 |..||::            ..:|.|.||::         :..|..
Human    61 LDM-----------------IETLKME------------HHLEAHKNGHANGHLNIGVDIPTPDG 96

  Fly   156 STGC-----GPPSS-----STCPCPQAECPSYVSDCDTYLRMGGRYVPPEYFKTAMSLGYSFVVT 210
            |...     |.|:.     ...|.|:.|...|               |.|:.||.::..|:....
Human    97 SFSIKIKPNGMPNGYRKEMIKIPMPELERSQY---------------PMEWGKTFLAFLYALSCF 146

  Fly   211 WITSLTMVIVHERVPDMKRYPPLPDIFLDNVPHIPWAFNMCEITGSLLFTIWVVVLTFHKYRLVL 275
            .:|::.:.:||||||..:..|||||.|.|:...:.|||::|||.|.:|..:|::.....||:.::
Human   147 VLTTVMISVVHERVPPKEVQPPLPDTFFDHFNRVQWAFSICEINGMILVGLWLIQWLLLKYKSII 211

  Fly   276 LRRFFALAGTVFLLRCVTMLITSLSVPGTHLQCSQKDFAIDDPNVDMVGALIIRMSRAYRIWSGL 340
            .||||.:.||::|.||:||.:|:|.|||.|..||.|.|          |....::.|..::.:|.
Human   212 SRRFFCIVGTLYLYRCITMYVTTLPVPGMHFNCSPKLF----------GDWEAQLRRIMKLIAGG 266

  Fly   341 GMSIQGVRT-CGDYMFSGHTVALTLLNFFITEYTPRNLYFLHTLTWLLNMFGIFFILAAHEHYSI 404
            |:||.|... ||||::|||||.|||...||.||:||.|::.|.:.|||::.|||.||.||:||::
Human   267 GLSITGSHNMCGDYLYSGHTVMLTLTYLFIKEYSPRRLWWYHWICWLLSVVGIFCILLAHDHYTV 331

  Fly   405 DVFVAFYITSRLFLYYHTLANNRALMQSDSKR--TRV-WFPMFSYFESSVDGMVPNEY 459
            ||.||:|||:|||.:|||:||.:.|.::....  .|| |:..|.|||.:|.|:||..|
Human   332 DVVVAYYITTRLFWWYHTMANQQVLKEASQMNLLARVWWYRPFQYFEKNVQGIVPRSY 389

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMSr	NP_648114.1	SAM_SGMS1-like	55..126	CDD:188914	19/87 (22%)
		PAP2_C	349..422	CDD:464150	43/73 (59%)
SGMS1	NP_671512.1	SAM_SGMS1	1..72	CDD:188913	20/104 (19%)
		PAP2_C	276..349	CDD:464150	43/72 (60%)