DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment akirin and AKIRIN1

DIOPT Version :9

Sequence 1:	NP_001189058.1	Gene:	akirin / 38821	FlyBaseID:	FBgn0082598	Length:	201	Species:	Drosophila melanogaster
Sequence 2:	NP_078871.1	Gene:	AKIRIN1 / 79647	HGNCID:	25744	Length:	192	Species:	Homo sapiens

Alignment Length:	208	Identity:	76/208 - (36%)
Similarity:	113/208 - (54%)	Gaps:	23/208 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAC-ATLKRALDWESMNQRP--PKRRRCNPFGQAGSNAGPASPSRDGPSTSAGLPHTPSNRFAKD 62
            ||| |||||.:::|:....|  ||||||.|.  .|...|...|..:.|      |...:....:.
Human     1 MACGATLKRPMEFEAALLSPGSPKRRRCAPL--PGPTPGLRPPDAEPP------PPFQTQTPPQS 57

  Fly    63 STEPS-PFSESSLAKMSPDKMAESLCNEIKRLHKRKQLPITSSALERMQDSESSGSEMGPESP-- 124
            ..:|: |.||..|.  :|:::.:::..|..|..:.:.|.:.      :..||:..||..|.|.
Human    58 LQQPAPPGSERRLP--TPEQIFQNIKQEYSRYQRWRHLEVV------LNQSEACASESQPHSSAL 114

  Fly   125 RRPDSPQNLMRHGEKALFTFKQVQLICESMIKERENQLRERYESVLTTKLAEQYDAFVKFTYDQI 189
            ..|.||.:.....::..||.:||.:|||.::|:.|:::||.||.:|.|||||||::|||||:|||
Human   115 TAPSSPGSSWMKKDQPTFTLRQVGIICERLLKDYEDKIREEYEQILNTKLAEQYESFVKFTHDQI 179

  Fly   190 QRRYEAAP-SYLS 201
            .|||...| ||:|
Human   180 MRRYGTRPTSYVS 192

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
akirin	NP_001189058.1	akirin	2..201	CDD:425410	74/205 (36%)
AKIRIN1	NP_078871.1	akirin-1	2..192	CDD:412035	74/205 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	17..71		17/61 (28%)
		Nuclear localization signal	23..28		4/4 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	104..127		7/22 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145950
Domainoid	1	1.000	129	1.000	Domainoid score	I5263
eggNOG	1	0.900	-	-		E1_KOG4330
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	129	1.000	Inparanoid score	I4665
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1420469at2759
OrthoFinder	1	1.000	-	-		FOG0003080
OrthoInspector	1	1.000	-	-		otm41890
orthoMCL	1	0.900	-	-		OOG6_105453
Panther	1	1.100	-	-	O	PTHR13293
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4225
SonicParanoid	1	1.000	-	-		X2925
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790