DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment akirin and AKIRIN2

DIOPT Version :9

Sequence 1:	NP_001189058.1	Gene:	akirin / 38821	FlyBaseID:	FBgn0082598	Length:	201	Species:	Drosophila melanogaster
Sequence 2:	NP_060534.1	Gene:	AKIRIN2 / 55122	HGNCID:	21407	Length:	203	Species:	Homo sapiens

Alignment Length:	207	Identity:	83/207 - (40%)
Similarity:	121/207 - (58%)	Gaps:	10/207 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAC-ATLKRALDWES-MNQRPPKRRRCNPFGQAGSNAGPASPSRDGPSTSAGLPHTPSNRFAKDS 63
            ||| |||||.||::. ::...||||||.|.....|.|  |||.....:|:|......::......
Human     1 MACGATLKRTLDFDPLLSPASPKRRRCAPLSAPTSAA--ASPLSAAAATAASFSAAAASPQKYLR 63

  Fly    64 TEPSPFSESSLAKMSPDKMAESLCNEIKRLHKRKQLPITSSALERMQDSESSGSEM---GPESPR 125
            .|||||.:.| ::::.:::..::..|.||:.||:.|..:....:....|::.....   ||.||.
Human    64 MEPSPFGDVS-SRLTTEQILYNIKQEYKRMQKRRHLETSFQQTDPCCTSDAQPHAFLLSGPASPG 127

  Fly   126 RPDSPQNLMRHGEKALFTFKQVQLICESMIKERENQLRERYESVLTTKLAEQYDAFVKFTYDQIQ 190
            ...:..:.::. |:.|||.:||.:|||.::||||.::||.||.:|.||||||||||||||:|||.
Human   128 TSSAASSPLKK-EQPLFTLRQVGMICERLLKEREEKVREEYEEILNTKLAEQYDAFVKFTHDQIM 191

  Fly   191 RRYEAAP-SYLS 201
            |||...| ||:|
Human   192 RRYGEQPASYVS 203

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
akirin	NP_001189058.1	akirin	2..201	CDD:425410	81/204 (40%)
AKIRIN2	NP_060534.1	akirin-2	2..203	CDD:412036	81/204 (40%)
AKIRIN2	NP_060534.1	Nuclear localization signal	22..27		4/4 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145951
Domainoid	1	1.000	129	1.000	Domainoid score	I5263
eggNOG	1	0.900	-	-		E1_KOG4330
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9988
Inparanoid	1	1.050	129	1.000	Inparanoid score	I4665
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48613
OrthoDB	1	1.010	-	-		D1420469at2759
OrthoFinder	1	1.000	-	-		FOG0003080
OrthoInspector	1	1.000	-	-		otm41890
orthoMCL	1	0.900	-	-		OOG6_105453
Panther	1	1.100	-	-	LDO	PTHR13293
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4225
SonicParanoid	1	1.000	-	-		X2925
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800