Protein Alignment Sh3beta and AIP5

DIOPT Version :10

• Sequence 1: NP_001189057.1
• Gene: Sh3beta / 38820
• FlyBaseID: FBgn0035772
• Length: 485
• Species: Drosophila melanogaster
• Sequence 2: NP_116671.1
• Gene: AIP5 / 850570
• SGDID: S000001912
• Length: 1233
• Species: Saccharomyces cerevisiae
• Alignment Length: 600
• Identity: 153/600 - (25%)
• Similarity: 241/600 - (40%)
• Gaps: 173/600 - (28%)

  Fly    10 MSGNKEVKKRQQRVLMI-----LDSKNIKYDTVDITEPGKESEKELMQNKSTSNGGTVSDPE-PR 68
            |.|:::..:..::..:|     .:|..|..|.:.:.:   |:|....:||.|...|.:..|: ||
Yeast   516 MGGDEKQSEAGEKSSIIEIEGSANSAKISKDNLVLED---EAEAPTQENKPTEVVGEIDIPDAPR 577

  Fly    69 -----------HPLPPQLFNDDEYCGDYDAFDMANEIDTLEVFLKLAPADTTAVSTAQ-----IE 117
                       :.:|..|....|        |...|...|:..:|....|..|:..|:     ::
Yeast   578 DDVEIVEAVEKNIIPEDLEVAKE--------DQEGEQVKLDEPVKAMKDDKIAMRGAESISEDMK 634

  Fly   118 LKQE------NGDAKKEEAET--------EAEDKKT----------------------------- 139
            .|||      |..||||..||        |.|..||
Yeast   635 KKQEGTAELSNEKAKKEVDETARESAEGVEVEKSKTPESPKVVKRCTSGRPEDLQINERDPEVLK 699

  Fly   140 -EAGDGDVDVKEEAAEKAENEDGKDKENSK------------------GEDEDADEENAEQKTET 185
             :....|.|||.|.|...||.:.:|.::.:                  |......||...::.|.
Yeast   700 EDVRVPDEDVKPEIATTIENSEEEDPKSQRVQISTEQAETTQKDMGDVGSTTSFKEEEKPKRFEI 764

  Fly   186 EESGDKKTEEKTTDAEGETQE------KSEEVDTKEKSEVESTKDDEVGKSEDVKDDEDEKSEIV 244
            .:.|||.|.:.|....||..|      |:.:|.|.|| .:|.:       ||.||.|.:|.:|:
Yeast   765 TQEGDKITGKDTNHEHGEATEAASENSKASDVGTAEK-YIEPS-------SESVKKDTEEDAEV- 820

  Fly   245 KDDKENSQDVKDDKTEKSEDVKDKLEGSEETAETSEDADTT-----EKPDVEA-TNDDGDTK-SE 302
                |||        ||:|.:|.|.|  .|..:..::|:.|     |..|||. |.:|.:.: ||
Yeast   821 ----ENS--------EKTEFIKVKAE--LENLDAPKEAEVTAELNKENEDVEVDTEEDAEVENSE 871

  Fly   303 KNE-TQEKSE--EVDAVEESE--AESSKEKTEENDTKGTKVNENDKDEDVEEKTEENATEESADS 362
            |.| .:.|:|  .:||.:|:|  ||.:|| .|:.:...|      ..||:|.|..|.| |...:.
Yeast   872 KTEFIKVKAELGNLDAPKEAEVTAELNKE-NEDVEVAAT------SKEDIETKCSEPA-ETPIED 928

  Fly   363 DSATKSEVKSTEDDEVVESEDVKDEFEENETNKKVEE-----VGSTEISEV-VSTENEKF----- 416
            .:.|::|| |.:|.|.|..||      ||..|.|:.|     .|..||.:: :|.|.::.
Yeast   929 GTCTEAEV-SKKDAEAVTKED------ENMENSKIAEALKDVTGDQEIDDINISDEFQRTVELPE 986

  Fly   417 ---EDIKENPNEN---EAQEKPEEV----MTAERSVEETKEEEPIDEEKPAETKTEDTPE-NEES 470
               :|||:|..|:   |.:|..:|.    :..|.::.|.|.|...:||:.::....:|.. ::|:
Yeast   987 LEKQDIKDNKGEDKELEVEETEKETSLPDLVVEENITEEKNEIKQEEEEVSQLDFNETESISKEA 1051

  Fly   471 KPDGENSSSEESEEE 485
            ..:.||...::|..|
Yeast  1052 PNNDENGFEDQSTRE 1066

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sh3beta	NP_001189057.1	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold	1..104	CDD:469754	22/110 (20%)
		2A1904	<138..392	CDD:273344	87/319 (27%)
AIP5	NP_116671.1	2A1904	<271..>528	CDD:273344	2/11 (18%)
		PTZ00121	<482..1082	CDD:173412	152/599 (25%)