DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sh3beta and Sh3bgr

DIOPT Version :9

Sequence 1:	NP_001189057.1	Gene:	Sh3beta / 38820	FlyBaseID:	FBgn0035772	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_056640.1	Gene:	Sh3bgr / 50795	MGIID:	1354740	Length:	214	Species:	Mus musculus

Alignment Length:	238	Identity:	77/238 - (32%)
Similarity:	126/238 - (52%)	Gaps:	31/238 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVLKVYVSGMSGNKEVKKRQQRVLMILDSKNIKYDTVDITEPGKESEKELMQ-----NKSTSNGG 60
            ||:||:|:..||:..::|:||.|:..|::..|.:..:||.  |.|..::.|:     .|...||
Mouse     1 MVIKVFVATSSGSIAIRKKQQEVVGFLEANKIDFKELDIA--GDEDNRKWMRENVPGEKKPQNG- 62

  Fly    61 TVSDPEPRHPLPPQLFNDDEYCGDYDAFDMANEIDTLEVFLKLAPADTTAVSTAQIELKQENGD- 124
                    .|||||:||:::||||:|:|..|.|.:.:..||.|||...:.|:.::......|||
Mouse    63 --------IPLPPQIFNEEQYCGDFDSFFSAKEENIIYSFLGLAPPPGSKVTKSEEASSLPNGDV 119

  Fly   125 AKKEEAETEAEDKKTEAGDGDVDVKEEAAEKAENEDGKDKENSKGEDEDADEENAEQKTETEESG 189
            |.:.|...|..:|..::|:.:.. ||::.:..|..:.::|:..:|||.:..||..|:    ||.|
Mouse   120 AGEAEGAAEGTEKAEKSGENEAQ-KEDSEDTGELSESQEKKEEEGEDGEEGEEGEER----EEGG 179

  Fly   190 DKKTEEKTTDAEGETQEKSEEVDTKEKSEVESTKDDEVGKSED 232
            :.:|       .|||:|..||....|..|.|  .::|.|:.||
Mouse   180 EGET-------TGETEEAPEEGAGGEAEEEE--PEEEAGEGED 213

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sh3beta	NP_001189057.1	Thioredoxin_like	1..104	CDD:294274	38/107 (36%)
Sh3bgr	NP_056640.1	SH3BGR	1..98	CDD:252868	38/107 (36%)
		SH3-binding. /evidence=ECO:0000255	61..67		4/14 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	101..214		36/127 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	75	1.000	Domainoid score	I9025
eggNOG	1	0.900	-	-		E1_KOG4023
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I5119
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1508713at2759
OrthoFinder	1	1.000	-	-		FOG0000625
OrthoInspector	1	1.000	-	-		otm44021
orthoMCL	1	0.900	-	-		OOG6_110742
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4755
SonicParanoid	1	1.000	-	-		X4396
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.760