DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sh3beta and sh3bgr

DIOPT Version :9

Sequence 1:	NP_001189057.1	Gene:	Sh3beta / 38820	FlyBaseID:	FBgn0035772	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	XP_005169739.1	Gene:	sh3bgr / 445130	ZFINID:	ZDB-GENE-040801-27	Length:	230	Species:	Danio rerio

Alignment Length:	262	Identity:	81/262 - (30%)
Similarity:	133/262 - (50%)	Gaps:	42/262 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVLKVYVSGMSGNKEVKKRQQRVLMILDSKNIKYDTVDITEPGKESEKELMQ-----NKSTSNGG 60
            ||:||:::..||:..:||:||.|:..|::..|.|..:||.  ..|..:..|:     .|..:||
Zfish     1 MVIKVFLASSSGSTAIKKKQQDVVGFLEALKIDYAQLDIA--SNEDNRAWMRENVPGEKKPTNG- 62

  Fly    61 TVSDPEPRHPLPPQLFNDDEYCGDYDAFDMANEIDTLEVFLKLA-PADTTAVSTAQIELKQENGD 124
                    .|||||:||::.||||||.|..|.|.:|:..||.|. |..:.....|:...|.:||.
Zfish    63 --------IPLPPQIFNEEMYCGDYDTFFDAKEDNTVYEFLGLTPPPGSKEAQQAENSQKLQNGS 119

  Fly   125 AKKEEAE---TEAEDKKTEAGDGDVDVKEEAAEKAENEDGKDKENSKGEDEDADEENAEQKTETE 186
            ..:|..:   |:.|.|:.|. :||       |..||.|:.::.:|::.:.:|.:||..|...|.|
Zfish   120 VTEEHPDDDTTKIELKEAEQ-NGD-------AHTAELEEDEESKNAETDAQDENEEEEEPAEEEE 176

  Fly   187 ESGDKKTEEKTTDAEGETQEKSEEVDTKEKSEVESTKDDEVGKSEDVKDDEDEKSEIVKDDKENS 251
            ||.....||:..:|||         |..|.:.:.|..:||:     |.::|:|..|:.::::..|
Zfish   177 ESRKPAEEEEQEEAEG---------DKVEDNHLVSEAEDEL-----VSEEEEELRELEEEEEHPS 227

  Fly   252 QD 253
            ::
Zfish   228 EE 229

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sh3beta	NP_001189057.1	Thioredoxin_like	1..104	CDD:294274	40/107 (37%)
sh3bgr	XP_005169739.1	GRX_SH3BGR	2..97	CDD:239328	39/105 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	79	1.000	Domainoid score	I8583
eggNOG	1	0.900	-	-		E1_KOG4023
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	81	1.000	Inparanoid score	I5187
OMA	1	1.010	-	-		QHG46667
OrthoDB	1	1.010	-	-		D1508713at2759
OrthoFinder	1	1.000	-	-		FOG0000625
OrthoInspector	1	1.000	-	-		otm26267
orthoMCL	1	0.900	-	-		OOG6_110742
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4755
SonicParanoid	1	1.000	-	-		X4396
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.770