Protein Alignment Sec63 and SEC63

DIOPT Version :10

• Sequence 1: NP_648111.1
• Gene: Sec63 / 38819
• FlyBaseID: FBgn0035771
• Length: 753
• Species: Drosophila melanogaster
• Sequence 2: NP_014897.1
• Gene: SEC63 / 854428
• SGDID: S000005780
• Length: 663
• Species: Saccharomyces cerevisiae
• Alignment Length: 840
• Identity: 171/840 - (20%)
• Similarity: 309/840 - (36%)
• Gaps: 279/840 - (33%)

  Fly     6 FQYDESGGTFYYFVLSFLALILIPTT------IYYWPRKKKQDNSKLKEECQCADCQKKKTILAN 64
            ::|||:..|:..|:|:.|.:::.|.|      |::....:..::.|.||              .|
Yeast     5 YEYDEASETWPSFILTGLLMVVGPMTLLQIYQIFFGANAEDGNSGKSKE--------------FN 55

  Fly    65 AEPYRAL----TSWTIK---------------------LTIVLGWALLLFLTYRVSQFD--YEMA 102
            .|.::.|    ||..||                     :.|::||.|:..|..|::..|  .:.|
Yeast    56 EEVFKNLNEEYTSDEIKQFRRKFDKNSNKKSKIWSRRNIIIIVGWILVAILLQRINSNDAIKDAA 120

  Fly   103 S--FDPFEILNVPPTSSQAEIKKAYYRLSKVLHPDK----ETGDEKS-----FMMLSKAYQALTD 156
            :  |||:|||.:..::|..:||.||.:||...||||    .|.||||     ::.::|||::|||
Yeast   121 TKLFDPYEILGISTSASDRDIKSAYRKLSVKFHPDKLAKGLTPDEKSVMEETYVQITKAYESLTD 185

  Fly   157 DVAKENYEKYGNPDGPGAMSFGIALPSWIVEKENSVWVLGLYGLVFMVAMPSAVGVWWYRSIRFS 221
            ::.::||.|||:||||.:.|.|||||.::|:...|..::..|..:..:.:|..|..||.|:..::
Yeast   186 ELVRQNYLKYGHPDGPQSTSHGIALPRFLVDGSASPLLVVCYVALLGLILPYFVSRWWARTQSYT 250

  Fly   222 GDKVLLDTTQMYFY--FIHKTPHMLLKRALMV--LAASLEFDKRHNSQVQERQSDNDEVPALIRQ 282
             .|.:.:.|...|.  .::..|..::...|::  |:.:.|| |:....:|
Yeast   251 -KKGIHNVTASNFVSNLVNYKPSEIVTTDLILHWLSFAHEF-KQFFPDLQ--------------- 298

  Fly   283 LPNLNEKCKEHPLCRMYSIKARAILHAHLSRMPLNPETLERDRQFVVKKCPYLVQEM--VSCVHQ 345
             |...||                :|..|::|.  :...|...:..:|.||..|:..:  ::|..:
Yeast   299 -PTDFEK----------------LLQDHINRR--DSGKLNNAKFRIVAKCHSLLHGLLDIACGFR 344

  Fly   346 LVMMAYARRVPRLPSIETIENCMKMSPMIIQGLWEFKSP---LLQLPHLTEDHLYFMNKKRHVKN 407
            .:.:|       |.:|.|.:..::..|:         :|   :||||::.::|  |:.|...:..
Yeast   345 NLDIA-------LGAINTFKCIVQAVPL---------TPNCQILQLPNVDKEH--FITKTGDIHT 391

  Fly   408 LQQFAQLKPEESRQLLKNLSDFEYENTMKVLGKMPLIDFSIRCEVIDDENTNVVTAGAIVTVTVT 472
            |.:...|:..:..::|......:...|::|...:|              |..::.|..:|
Yeast   392 LGKLFTLEDAKIGEVLGIKDQAKLNETLRVASHIP--------------NLKIIKADFLV----- 437

  Fly   473 LERKDMKTLFGDTKAPEKQGIKDETNEEAAGDEDEAAAAAPVKKASAWAKPRKGGKGKGGKKPAQ 537
                                                                          |.:
Yeast   438 --------------------------------------------------------------PGE 440

  Fly   538 NQKNQKKVPAKAATTATITASEDQAAAGNSDAESEAGNADGSDVESAAGSGSEDEEKGKNNSSLD 602
            ||......|  ..:...:..|..|.....|....|                           :|.
Yeast   441 NQVTPSSTP--YISLKVLVRSAKQPLIPTSLIPEE---------------------------NLT 476

  Fly   603 DDDDEEWERLQAKLNKRERLEGKSRLSHTVHCPYFPEEKQEYWWTYICDRKSRTLLTAPYHVTNL 667
            :..|.|.:|....:..::.|...|      ..|:||.:::..|...:..:|...:|..|..:..|
Yeast   477 EPQDFESQRDPFAMMSKQPLVPYS------FAPFFPTKRRGSWCCLVSSQKDGKILQTPIIIEKL 535

  Fly   668 VEK----------EEIQLKFT----------------------APRWPGVYTFTVCLRSDSYLGM 700
            ..|          :.|::..|                      ||...|.:.|.|.::|..|...
Yeast   536 SYKNLNDDKDFFDKRIKMDLTKHEKFDINDWEIGTIKIPLGQPAPETVGDFFFRVIVKSTDYFTT 600

  Fly   701 DQQQELKLDVQKAPAP------PTDHPQWDLSESEPEHTDQQENLSDYT---TDTSDEED 751
            |....:.:.|:.:||.      ..:..::...:.|.| :|.:.:.||||   |||..|:|
Yeast   601 DLDITMNMKVRDSPAVEQVEVYSEEDDEYSTDDDETE-SDDESDASDYTDIDTDTEAEDD 659

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec63	NP_648111.1	DnaJ	105..164	CDD:395170	28/67 (42%)
		SEC63	211..709	CDD:214744	80/538 (15%)
SEC63	NP_014897.1	DnaJ	125..192	CDD:395170	27/66 (41%)
		SEC63	240..611	CDD:214744	80/540 (15%)