DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec63 and ATERDJ2B

DIOPT Version :9

Sequence 1:	NP_648111.1	Gene:	Sec63 / 38819	FlyBaseID:	FBgn0035771	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	NP_567621.1	Gene:	ATERDJ2B / 827866	AraportID:	AT4G21180	Length:	661	Species:	Arabidopsis thaliana

Alignment Length:	825	Identity:	192/825 - (23%)
Similarity:	323/825 - (39%)	Gaps:	268/825 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 DESGGTFYYFVLSFLALILIPTTIYYWPR--KKKQDNSKLKEECQCADCQK----KKTILANAEP 67
            :|:...|..|:|:.:|:.|:|.|.....|  .|||.:.    .|||.:|.:    |::|..:...
plant     5 EENSVLFPIFILTMMAIPLVPYTFVKLSRAFSKKQRSI----HCQCLECDRSGKYKRSISQSISS 65

  Fly    68 YRALTSWTIKLTIVLGWALLLFLTYRVSQFDYEMASFDPFEILNVPPTSSQAEIKKAYYRLSKVL 132
            :.:.::    ||:||.|.:::||.|.......|...|:||.||.:.|.:|.:||||||.|||...
plant    66 FTSCSN----LTVVLLWIVMIFLIYHTKNMSRESQLFEPFGILGLEPGASDSEIKKAYRRLSIQY 126

  Fly   133 HPDKETGDE--KSFM-MLSKAYQALTDDVAKENYEKYGNPDGPGAMSFGIALPSWIVE---KENS 191
            ||||....|  |.|: .::||||||||.:::||:||||:|||....:.|||||.:|:.   :...
plant   127 HPDKNPDPEANKYFVESIAKAYQALTDPLSRENFEKYGHPDGRQGYTMGIALPQFILNMNGESGG 191

  Fly   192 VWVLGLYGLVFMVAMPSAVGVWWYRSIRFSGDKVLLDTTQMYFYFIHKTPHMLLKRALMVLAASL 256
            :.:|...||..::.:..| .::.:||.:::|:.|.|.|.|.||..:.  |.:...:.:.:...:.
plant   192 ILLLCTVGLCILLPLVIA-SIYLWRSSKYTGNHVKLQTRQAYFELLQ--PSLTPSKVMDIFIRAA 253

  Fly   257 EFDKRHNSQVQERQSDNDEVPAL---IRQLPNLNEK---------CKEHPLCRMYSIKARAILHA 309
            |:     :::..|:||::.:..|   ::...||:.|         .|:||.    :||...::..
plant   254 EY-----AEISVRKSDDESLQKLFMSVKSELNLDPKKLKQEEAKFWKKHPA----TIKTELLIQK 309

  Fly   310 HLSR--MPLNPETLERDRQFVVKKCPYLVQEMVSCVHQLVMMAYARRVPR--------LPSIETI 364
            .|:|  ..|:| ||:||.:.|::..|.|:::       |:.||.   :||        .|::
plant   310 QLTRESSVLSP-TLQRDFRHVLEFAPRLLED-------LIKMAV---IPRNEQGRGWLRPAL--- 360

  Fly   365 ENCMKMSPMIIQGL--------WEFKSPLLQLPHLTEDHLYFMNKKRHVKNLQQFAQLKPEESRQ 421
             ..|::|..|:|.:        .|..:|.|||||..|.  ...:....||:.|:|.:|...|..:
plant   361 -GVMELSQCIVQAVPLSARKSSSEDIAPFLQLPHFNES--IAKSIALQVKSFQKFQELSLAERSK 422

  Fly   422 LLK---NLSDFEYENTMKVLGKMPLIDFSIRCEVIDDENTNVVTAGAIVTVTVTLERKDMKTLFG 483
            ||:   :||:.:.::..|||..:|.:..::.|:...:|.   :..|.|:||...:..|....|.|
plant   423 LLREVVSLSETDVQDIEKVLEMIPSLKINVTCKTEGEEG---IQEGDIMTVQAWITLKRPNGLIG 484

  Fly   484 DTKAPEKQGIKDETNEEAAGDEDEAAAAAPVKKASAWAKPRKGGKGKGGKKPAQNQKNQKKVPAK 548
                                       |.|
plant   485 ---------------------------AIP----------------------------------- 487

  Fly   549 AATTATITASEDQAAAGNSDAESEAGNADGSDVESAAGSGSEDEEKGKNNSSLDDDDDEEWERLQ 613

plant   488 ----------------------------------------------------------------- 487

  Fly   614 AKLNKRERLEGKSRLSHTVHCPYFPEEKQEYWWTYICDRK--------------------SRTL- 657
                               |.||||..|:|.:|..:.|..                    |.|:
plant   488 -------------------HSPYFPFHKEENFWVLLADSNHVWFFQKVKFMDEAGAIAAASNTIT 533

  Fly   658 -----LTAPYHVTNLVEKEEIQL----------KFTAPRWPGVYTFTVCLRSDSYLGMDQQQELK 707
                 |.|....||...||.::.          :..|| ..|.|..|....||:::|.||:..||
plant   534 ETMEPLGASVKETNDAVKEAVEKVKSGSRLVMGRLLAP-GEGTYNLTCFCLSDTWIGCDQKTSLK 597

  Fly   708 LDVQKAPAPPTDHPQWDLSESEPEHTDQQENLSDYTTDTSDEEDG 752
            ::|.|...........:..|.|.:..::::..|:|:.|..|::.|
plant   598 VEVLKRTRDVEGENAEEGLEEEDDEIEEEDYESEYSEDEEDKKRG 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec63	NP_648111.1	DnaJ	105..164	CDD:278647	32/61 (52%)
		SEC63	211..709	CDD:214744	106/566 (19%)
		SEEEED	559..>626	CDD:291463	0/66 (0%)
ATERDJ2B	NP_567621.1	DnaJ	99..161	CDD:278647	32/61 (52%)
ATERDJ2B	NP_567621.1	SEC63	207..599	CDD:214744	107/570 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	41	1.000	Domainoid score	I4821
eggNOG	1	0.900	-	-		E1_COG5407
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	224	1.000	Inparanoid score	I1179
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D686427at2759
OrthoFinder	1	1.000	-	-		FOG0003537
OrthoInspector	1	1.000	-	-		otm2940
orthoMCL	1	0.900	-	-		OOG6_102234
Panther	1	1.100	-	-	O	PTHR24075
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2413
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.870