DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec63 and sec63

DIOPT Version :9

Sequence 1:	NP_648111.1	Gene:	Sec63 / 38819	FlyBaseID:	FBgn0035771	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	NP_001002588.1	Gene:	sec63 / 436861	ZFINID:	ZDB-GENE-040718-328	Length:	751	Species:	Danio rerio

Alignment Length:	781	Identity:	357/781 - (45%)
Similarity:	494/781 - (63%)	Gaps:	58/781 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAGQKFQYDESGGTFYYFVLSFLALILIPTTIYYWPRKKKQDNSKLKE------ECQCADCQKKK 59
            ||||:||||:||.||:||:.||:.||:||.|.|.|||.:..:..:||.      .|.....:..|
Zfish     1 MAGQQFQYDDSGNTFFYFLTSFVGLIVIPATYYIWPRDQNAEQLRLKSLRRVHGRCLWYRLRLMK 65

  Fly    60 TILANAEPYRALTSWTIKLTIVLGWALLLFLTYRVSQFDYEMASFDPFEILNVPPTSSQAEIKKA 124
            :       .:::.....|..::.|||:.|.|.|:||:.|.|...::|:|:||:...:|.|||||.
Zfish    66 S-------QQSIVPTLKKAALLFGWAVFLLLAYKVSKLDREYQEYNPYEVLNLEAGASVAEIKKQ 123

  Fly   125 YYRLSKVLHPDKETGDEKSFMMLSKAYQALTDDVAKENYEKYGNPDGPGAMSFGIALPSWIVEKE 189
            |..||...|||| .|||.:||.|:|||.|||::.:::|:|.|||||||...|||||||:|||:::
Zfish   124 YRVLSLKHHPDK-GGDEATFMKLAKAYSALTNEESRKNWEMYGNPDGPRVTSFGIALPAWIVDQK 187

  Fly   190 NSVWVLGLYGLVFMVAMPSAVGVWWYRSIRFSGDKVLLDTTQMYFYFIHKTPHMLLKRALMVLAA 254
            ||:.||.:|||.|||.:|..||.|||||||:|||::|::|||::.:|::|||.|.:||.:|||.|
Zfish   188 NSMLVLLVYGLAFMVILPVVVGTWWYRSIRYSGDQILINTTQLFMHFMYKTPTMNMKRLVMVLTA 252

  Fly   255 SLEFDKRHNSQVQERQSDNDEVPALIRQLPNLNEKCKEHPLCRMYSIKARAILHAHLSRMPLNPE 319
            :.|||.|.|.:...|.:||.|||.|||:|.|:|.|.||.|.|..||:|||.:|.|.|:||.:: |
Zfish   253 AFEFDPRSNKEAIIRPTDNIEVPQLIRELGNINVKKKEPPFCYPYSLKARVLLLAQLARMDVS-E 316

  Fly   320 TLERDRQFVVKKCPYLVQEMVSCVHQLVMMAYARRVPRLPSIETIENCMKMSPMIIQGLWEFKSP 384
            .:|.|::|||||||.|:|||::...||.|||.:|...|.|.:.:||||||:|.|::|||.|.|||
Zfish   317 NIEEDQRFVVKKCPALLQEMINVGCQLTMMATSRGGLRAPRLTSIENCMKLSQMVVQGLQEAKSP 381

  Fly   385 LLQLPHLTEDHL-YFMNKKRHVKNLQQFAQLKPEESRQLLKNLSDFEYENTMKVLGKMPLIDFSI 448
            ||||||..|:|| |.::||..|:.||....||..:.|.:|:.|.:.:|:..:.|||..|.|:...
Zfish   382 LLQLPHFEEEHLRYCISKKYKVRTLQDLVSLKDSDRRNMLRFLGEEKYDEVIGVLGSFPYINMET 446

  Fly   449 RCEVIDDENTNVVTAGAIVTVTVTLERKDMKTLF-GDTKAPEKQGIKDETNEEAAGDEDEAAAAA 512
            :.:|:|||::|.:|||:||||||.|.||.|..:| .:..||..   .:|.|.|..||..
Zfish   447 KLQVLDDEDSNNITAGSIVTVTVILTRKRMSEMFEKEENAPLP---AEEVNTEEQGDAK------ 502

  Fly   513 PVKKASAWAKPRKGGKGKGGKKPAQNQKNQKKVPAKAATTATITASEDQA------AAGN---SD 568
              .|...|.     .|.||.||.|:.:|  ||:..|...|.. .|..|:|      .|||   |.
Zfish   503 --NKTKVWQ-----NKNKGAKKAAKPKK--KKLTKKKPVTQQ-QAKGDKAKQANGNVAGNEVVSK 557

  Fly   569 AESEAGNADGSDVESAAG---SGSE-DEEKGKNNSSLDD----DDDEEWERLQAKLNKRER--LE 623
            .|.|..:..||:.:.|.|   |.|| |:|..|.:.:..|    ||:||||.||..:.:|||  ||
Zfish   558 EEEEDLSDKGSESDEAEGNKDSPSERDDESDKQSDTEGDEIARDDEEEWEALQQSIQRRERALLE 622

  Fly   624 GKSRLSHTVHCPYFPEEKQEYWWTYICDRKSRTLLTAPYHVTNLVEKEEIQLKFTAPRWPGVYTF 688
            .||:::|.|:..:|||||||:||.||.|||.:||::.|.||..|.:.||::|||.||...|.|.:
Zfish   623 TKSKVTHPVYSLFFPEEKQEWWWLYIADRKEQTLVSMPNHVCTLKDTEEVELKFPAPSKTGNYQY 687

  Fly   689 TVCLRSDSYLGMDQQQELKLDVQKAPAPPTDHPQWDLSESEPEHTDQQENLSDYTTDT-SDEEDG 752
            :|.|||||::|:||.:.|||:|.:|.|...:|||||:.|:|.|..||::  ||...:: .||||.
Zfish   688 SVILRSDSFMGLDQIKPLKLEVHEAKAMMDNHPQWDIPETEEEEDDQED--SDGIEESEEDEEDN 750

  Fly   753 E 753
            :
Zfish   751 D 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec63	NP_648111.1	DnaJ	105..164	CDD:278647	30/58 (52%)
		SEC63	211..709	CDD:214744	237/518 (46%)
		SEEEED	559..>626	CDD:291463	32/85 (38%)
sec63	NP_001002588.1	DnaJ	104..162	CDD:278647	30/58 (52%)
		SEC63	209..708	CDD:214744	237/518 (46%)
		Ribosomal_L24e_L24	<531..608	CDD:294589	26/77 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595339
Domainoid	1	1.000	238	1.000	Domainoid score	I2244
eggNOG	1	0.900	-	-		E1_COG5407
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5220
Inparanoid	1	1.050	630	1.000	Inparanoid score	I824
OMA	1	1.010	-	-		QHG56112
OrthoDB	1	1.010	-	-		D176261at33208
OrthoFinder	1	1.000	-	-		FOG0003537
OrthoInspector	1	1.000	-	-		oto41066
orthoMCL	1	0.900	-	-		OOG6_102234
Panther	1	1.100	-	-	LDO	PTHR24075
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1312
SonicParanoid	1	1.000	-	-		X2413
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800