Protein Alignment Sec63 and Brr2

DIOPT Version :10

• Sequence 1: NP_648111.1
• Gene: Sec63 / 38819
• FlyBaseID: FBgn0035771
• Length: 753
• Species: Drosophila melanogaster
• Sequence 2: NP_648818.3
• Gene: Brr2 / 39737
• FlyBaseID: FBgn0263599
• Length: 2142
• Species: Drosophila melanogaster
• Alignment Length: 513
• Identity: 104/513 - (20%)
• Similarity: 179/513 - (34%)
• Gaps: 206/513 - (40%)

  Fly   233 YFYFIHKTPHML---------LKRALMVLAASLEFD----KRHNSQVQERQSDNDEVPALIRQLP 284
            |:|..:.|..:.         ::..|.:::::.|::    :.|..||         :..|.::||
  Fly  1820 YYYINYTTIELFSLSLNSKTKVRGLLEIISSAAEYEDVVVRHHEEQV---------LRTLSQRLP 1875

  Fly   285 N-LNEKCKEHPLCRMYSIKARAILHAHLSRMPLNPETLERDRQFVVKKCPYLVQEMVSCVHQLVM 348
            | |....:..|......||...:|.|||||:.|.|| |:.|.:.::.|...|:|   :||..|..
  Fly  1876 NKLTGPNETAPKFNDPHIKTNLLLQAHLSRLQLGPE-LQGDTEQILSKAIRLIQ---ACVDVLSS 1936

  Fly   349 MAYARRVPRLPSIETIENCMKMSPMIIQGLWEFKSPLLQLPHLTEDHLYFMNKKRHVKNLQQFAQ 413
            ..:..     |::.    .|:::.|:.|.:|...|.|.||||.:.:.:....:|: ::.:....:
  Fly  1937 NGWLS-----PAVA----AMELAQMVTQAMWSKDSYLKQLPHFSPEIVKRCTEKK-IETVFDIME 1991

  Fly   414 LKPEESRQLLKNLSDFEYENTMKVLGKMPLIDFSIRCEVIDDENTNVVTAGAIVTVTVTLERKDM 478
            |:.|:..:||: |||.:..:..:...:.|.|:  :..||:|.:..|   :|:.|.|.|.|||
  Fly  1992 LEDEDRTRLLQ-LSDLQMADVARFCNRYPNIE--LNYEVVDKDRIN---SGSTVNVVVQLER--- 2047

  Fly   479 KTLFGDTKAPEKQGIKDETNEEAAGDEDEAAAAAPVKKASAWAKPRKGGKGKGGKKPAQNQKNQK 543
                                                                             
  Fly  2048 ----------------------------------------------------------------- 2047

  Fly   544 KVPAKAATTATITASEDQAAAGNSDAESEAGNADGSDVESAAGSGSEDEEKGKNNSSLDDDDDEE 608
                                                          |||..|
  Fly  2048 ----------------------------------------------EDEVTG------------- 2053

  Fly   609 WERLQAKLNKRERLEGKSRLSHTVHCPYFPEEKQEYWWTYICDRKSRTLLTAPYHVTNLVEKEEI 673
                                  .|..|:||::::|.||..|.|.|:.:||:...  ..|.:|.::
  Fly  2054 ----------------------PVIAPFFPQKREEGWWVVIGDPKTNSLLSIKR--LTLQQKAKV 2094

  Fly   674 QLKFTAPRWPGVYTFTVCLRSDSYLGMDQQQELKLDVQKAPAPPTDHPQWDLSESEPE 731
            :|.|.||. ||.:.:|:...||||||.||:.:..::|....           ||||.|
  Fly  2095 KLDFVAPS-PGKHDYTLYYMSDSYLGCDQEYKFSIEVGDFQ-----------SESESE 2140

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec63	NP_648111.1	DnaJ	105..164	CDD:395170
		SEC63	211..709	CDD:214744	98/489 (20%)
Brr2	NP_648818.3	Helicase_PWI	259..368	CDD:436309
		DEXHc_Brr2_1	464..677	CDD:350777
		BRR2	476..1020	CDD:440817
		Sec63	982..1285	CDD:460740
		BRR2	1309..1848	CDD:440817	4/27 (15%)
		DEXHc_Brr2_2	1325..1514	CDD:350779
		Sec63	1811..2127	CDD:460740	98/487 (20%)