DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec63 and Sec63

DIOPT Version :9

Sequence 1:	NP_648111.1	Gene:	Sec63 / 38819	FlyBaseID:	FBgn0035771	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	XP_006256632.1	Gene:	Sec63 / 309858	RGDID:	1304984	Length:	760	Species:	Rattus norvegicus

Alignment Length:	773	Identity:	339/773 - (43%)
Similarity:	486/773 - (62%)	Gaps:	36/773 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAGQKFQYDESGGTFYYFVLSFLALILIPTTIYYWPRKKKQDNSKLKEECQC-ADCQKKKTILAN 64
            ||||:||||:||.||:||:.||:.||:||.|.|.|||.:..:..:||...:. ..|...:..|..
  Rat     1 MAGQQFQYDDSGNTFFYFLTSFVGLIVIPATYYLWPRDQNAEQIRLKNIRKVYGRCMWYRLRLLK 65

  Fly    65 AEPYRALTSWTIKLTIVLGWALLLFLTYRVSQFDYEMASFDPFEILNVPPTSSQAEIKKAYYRLS 129
            .:|  .:.....|:.::.||||.|||.|:||:.|.|...::|:|:||:.|.::.|||||.|..||
  Rat    66 PQP--NIIPTVKKIVLLAGWALFLFLAYKVSKTDREYQEYNPYEVLNLDPGATVAEIKKQYRLLS 128

  Fly   130 KVLHPDKETGDEKSFMMLSKAYQALTDDVAKENYEKYGNPDGPGAMSFGIALPSWIVEKENSVWV 194
            ...|||| .|||..||.::|||.||||:.:::|:|::||||||.|.|||||||:|||:::||:.|
  Rat   129 LKYHPDK-GGDEVMFMRIAKAYAALTDEESRKNWEEFGNPDGPQATSFGIALPAWIVDQKNSILV 192

  Fly   195 LGLYGLVFMVAMPSAVGVWWYRSIRFSGDKVLLDTTQMYFYFIHKTPHMLLKRALMVLAASLEFD 259
            |.:|||.|||.:|..||.|||||||:|||::|:.|||:|.||::||.:|.:||.:||||.:.|||
  Rat   193 LLVYGLAFMVILPVVVGSWWYRSIRYSGDQILIRTTQIYTYFVYKTRNMDMKRLIMVLAGASEFD 257

  Fly   260 KRHNSQVQERQSDNDEVPALIRQLPNLNEKCKEHPLCRMYSIKARAILHAHLSRMPLNPETLERD 324
            .::|.....|.:||..:|.|||::.::|.|..|.||...||:|||.:|.:||:||.: |||||.|
  Rat   258 PQYNKDATSRPTDNVLIPQLIREIGSINLKKNEPPLTCPYSLKARVLLLSHLARMKI-PETLEED 321

  Fly   325 RQFVVKKCPYLVQEMVSCVHQLVMMAYAR--RVPRLPSIETIENCMKMSPMIIQGLWEFKSPLLQ 387
            :||::||||.|:||||:.:.||::||.:|  |..|.|::.::|||||:|.|.:|||.:|||||||
  Rat   322 QQFMLKKCPALLQEMVNVICQLIIMARSREEREFRAPTLASLENCMKLSQMAVQGLQQFKSPLLQ 386

  Fly   388 LPHLTEDHLYFM--NKKRHVKNLQQFAQLKPEESRQLLKNLSDFEYENTMKVLGKMPLIDFSIRC 450
            |||:.||:|..:  :||..:|::|....||..:...||..|.|.:||..|.|||..|.:...|:.
  Rat   387 LPHIEEDNLRRVSNHKKFKIKSIQDLVSLKEADRHSLLHFLEDEKYEEVMAVLGSFPYVTMDIKS 451

  Fly   451 EVIDDENTNVVTAGAIVTVTVTLERKDMKTLFGDTKAPEKQGIKDETNEEAAGDEDEAAAAAPVK 515
            :|:|||::|.:|.|::|||.|.|.|:.|..:|      ||:.......|:.|  ||..:.|...|
  Rat   452 QVLDDEDSNNITVGSLVTVLVKLTRQTMAEVF------EKEQSICAAEEQPA--EDGQSDANKNK 508

  Fly   516 KASAWAKPRKGGK--GKGGKK------------PAQNQKNQKKVPAKAATTATITASEDQAAAGN 566
            ....|.:..||.|  .|..||            |...|:.||:......:.|.:...|:..:...
  Rat   509 AKGGWQQKNKGPKKMPKSKKKKPLKKKPTTVPLPQGKQQKQKQANGVVGSEAAMKEEEEDISDKG 573

  Fly   567 SDAESEAGNADGSDVESAAGSGSEDEEKGKNNSSLDDDDDEEWERLQAKLNKRER--LEGKSRLS 629
            ||:|.|..|.|.   :|....||:.:...:.:.....||:.||:.||..:.::||  ||.||:::
  Rat   574 SDSEEEETNRDS---QSEKDDGSDRDSDREQDEKQSKDDEAEWQELQQSIQRKERALLETKSKIT 635

  Fly   630 HTVHCPYFPEEKQEYWWTYICDRKSRTLLTAPYHVTNLVEKEEIQLKFTAPRWPGVYTFTVCLRS 694
            |.|:..||||||||:||.||.|:|.:||::.||||..|.:.||::|||.||..||.:.:||.|||
  Rat   636 HPVYSLYFPEEKQEWWWLYIADKKEQTLISMPYHVCTLKDTEEVELKFPAPGRPGNHQYTVFLRS 700

  Fly   695 DSYLGMDQQQELKLDVQKAPAPPTDHPQWDLSESEPEHTDQQENLSDYTTDTSDEEDG 752
            |||:|:||.:.|||:|.:|...|.:|||||.:....|..:..|...|...:..:||:|
  Rat   701 DSYMGLDQTKPLKLEVHEAKPVPENHPQWDTAIEGDEDQEDSEGFEDSFEEEEEEEEG 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec63	NP_648111.1	DnaJ	105..164	CDD:278647	30/58 (52%)
		SEC63	211..709	CDD:214744	221/517 (43%)
		SEEEED	559..>626	CDD:291463	20/68 (29%)
Sec63	XP_006256632.1	DnaJ	104..162	CDD:278647	29/57 (51%)
		SEC63	209..715	CDD:214744	225/525 (43%)
		SEEEED	564..>612	CDD:291463	13/47 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353247
Domainoid	1	1.000	226	1.000	Domainoid score	I2436
eggNOG	1	0.900	-	-		E1_COG5407
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5220
Inparanoid	1	1.050	631	1.000	Inparanoid score	I810
OMA	1	1.010	-	-		QHG56112
OrthoDB	1	1.010	-	-		D176261at33208
OrthoFinder	1	1.000	-	-		FOG0003537
OrthoInspector	1	1.000	-	-		oto97046
orthoMCL	1	0.900	-	-		OOG6_102234
Panther	1	1.100	-	-	LDO	PTHR24075
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2413
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810