Protein Alignment Sec63 and Sec63

DIOPT Version :10

• Sequence 1: NP_648111.1
• Gene: Sec63 / 38819
• FlyBaseID: FBgn0035771
• Length: 753
• Species: Drosophila melanogaster
• Sequence 2: NP_001421558.1
• Gene: Sec63 / 309858
• RGDID: 1304984
• Length: 760
• Species: Rattus norvegicus
• Alignment Length: 773
• Identity: 339/773 - (43%)
• Similarity: 486/773 - (62%)
• Gaps: 36/773 - (4%)

  Fly     1 MAGQKFQYDESGGTFYYFVLSFLALILIPTTIYYWPRKKKQDNSKLKEECQC-ADCQKKKTILAN 64
            ||||:||||:||.||:||:.||:.||:||.|.|.|||.:..:..:||...:. ..|...:..|..
  Rat     1 MAGQQFQYDDSGNTFFYFLTSFVGLIVIPATYYLWPRDQNAEQIRLKNIRKVYGRCMWYRLRLLK 65

  Fly    65 AEPYRALTSWTIKLTIVLGWALLLFLTYRVSQFDYEMASFDPFEILNVPPTSSQAEIKKAYYRLS 129
            .:|  .:.....|:.::.||||.|||.|:||:.|.|...::|:|:||:.|.::.|||||.|..||
  Rat    66 PQP--NIIPTVKKIVLLAGWALFLFLAYKVSKTDREYQEYNPYEVLNLDPGATVAEIKKQYRLLS 128

  Fly   130 KVLHPDKETGDEKSFMMLSKAYQALTDDVAKENYEKYGNPDGPGAMSFGIALPSWIVEKENSVWV 194
            ...|||| .|||..||.::|||.||||:.:::|:|::||||||.|.|||||||:|||:::||:.|
  Rat   129 LKYHPDK-GGDEVMFMRIAKAYAALTDEESRKNWEEFGNPDGPQATSFGIALPAWIVDQKNSILV 192

  Fly   195 LGLYGLVFMVAMPSAVGVWWYRSIRFSGDKVLLDTTQMYFYFIHKTPHMLLKRALMVLAASLEFD 259
            |.:|||.|||.:|..||.|||||||:|||::|:.|||:|.||::||.:|.:||.:||||.:.|||
  Rat   193 LLVYGLAFMVILPVVVGSWWYRSIRYSGDQILIRTTQIYTYFVYKTRNMDMKRLIMVLAGASEFD 257

  Fly   260 KRHNSQVQERQSDNDEVPALIRQLPNLNEKCKEHPLCRMYSIKARAILHAHLSRMPLNPETLERD 324
            .::|.....|.:||..:|.|||::.::|.|..|.||...||:|||.:|.:||:||.: |||||.|
  Rat   258 PQYNKDATSRPTDNVLIPQLIREIGSINLKKNEPPLTCPYSLKARVLLLSHLARMKI-PETLEED 321

  Fly   325 RQFVVKKCPYLVQEMVSCVHQLVMMAYAR--RVPRLPSIETIENCMKMSPMIIQGLWEFKSPLLQ 387
            :||::||||.|:||||:.:.||::||.:|  |..|.|::.::|||||:|.|.:|||.:|||||||
  Rat   322 QQFMLKKCPALLQEMVNVICQLIIMARSREEREFRAPTLASLENCMKLSQMAVQGLQQFKSPLLQ 386

  Fly   388 LPHLTEDHLYFM--NKKRHVKNLQQFAQLKPEESRQLLKNLSDFEYENTMKVLGKMPLIDFSIRC 450
            |||:.||:|..:  :||..:|::|....||..:...||..|.|.:||..|.|||..|.:...|:.
  Rat   387 LPHIEEDNLRRVSNHKKFKIKSIQDLVSLKEADRHSLLHFLEDEKYEEVMAVLGSFPYVTMDIKS 451

  Fly   451 EVIDDENTNVVTAGAIVTVTVTLERKDMKTLFGDTKAPEKQGIKDETNEEAAGDEDEAAAAAPVK 515
            :|:|||::|.:|.|::|||.|.|.|:.|..:|      ||:.......|:.|  ||..:.|...|
  Rat   452 QVLDDEDSNNITVGSLVTVLVKLTRQTMAEVF------EKEQSICAAEEQPA--EDGQSDANKNK 508

  Fly   516 KASAWAKPRKGGK--GKGGKK------------PAQNQKNQKKVPAKAATTATITASEDQAAAGN 566
            ....|.:..||.|  .|..||            |...|:.||:......:.|.:...|:..:...
  Rat   509 AKGGWQQKNKGPKKMPKSKKKKPLKKKPTTVPLPQGKQQKQKQANGVVGSEAAMKEEEEDISDKG 573

  Fly   567 SDAESEAGNADGSDVESAAGSGSEDEEKGKNNSSLDDDDDEEWERLQAKLNKRER--LEGKSRLS 629
            ||:|.|..|.|.   :|....||:.:...:.:.....||:.||:.||..:.::||  ||.||:::
  Rat   574 SDSEEEETNRDS---QSEKDDGSDRDSDREQDEKQSKDDEAEWQELQQSIQRKERALLETKSKIT 635

  Fly   630 HTVHCPYFPEEKQEYWWTYICDRKSRTLLTAPYHVTNLVEKEEIQLKFTAPRWPGVYTFTVCLRS 694
            |.|:..||||||||:||.||.|:|.:||::.||||..|.:.||::|||.||..||.:.:||.|||
  Rat   636 HPVYSLYFPEEKQEWWWLYIADKKEQTLISMPYHVCTLKDTEEVELKFPAPGRPGNHQYTVFLRS 700

  Fly   695 DSYLGMDQQQELKLDVQKAPAPPTDHPQWDLSESEPEHTDQQENLSDYTTDTSDEEDG 752
            |||:|:||.:.|||:|.:|...|.:|||||.:....|..:..|...|...:..:||:|
  Rat   701 DSYMGLDQTKPLKLEVHEAKPVPENHPQWDTAIEGDEDQEDSEGFEDSFEEEEEEEEG 758

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec63	NP_648111.1	DnaJ	105..164	CDD:395170	30/58 (52%)
		SEC63	211..709	CDD:214744	221/517 (43%)
Sec63	NP_001421558.1	DnaJ	104..162	CDD:395170	29/57 (51%)
		SEC63	209..715	CDD:214744	225/525 (43%)