DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec63 and Sec63

DIOPT Version :9

Sequence 1:	NP_648111.1	Gene:	Sec63 / 38819	FlyBaseID:	FBgn0035771	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	NP_694695.3	Gene:	Sec63 / 140740	MGIID:	2155302	Length:	760	Species:	Mus musculus

Alignment Length:	783	Identity:	348/783 - (44%)
Similarity:	489/783 - (62%)	Gaps:	56/783 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAGQKFQYDESGGTFYYFVLSFLALILIPTTIYYWPRKKKQDNSKLKEECQC-ADCQKKKTILAN 64
            ||||:||||:||.||:||:.||:.||:||.|.|.|||.:..:..:||...:. ..|...:..|..
Mouse     1 MAGQQFQYDDSGNTFFYFLTSFVGLIVIPATYYLWPRDQNAEQIRLKNIRKVYGRCMWYRLRLLK 65

  Fly    65 AEPYRALTSWTIKLTIVLGWALLLFLTYRVSQFDYEMASFDPFEILNVPPTSSQAEIKKAYYRLS 129
            .:|  .:.....|:.::.||||.|||.|:||:.|.|...::|:|:||:.|.::.|||||.|..||
Mouse    66 PQP--NIIPTVKKIVLLAGWALFLFLAYKVSKTDREYQEYNPYEVLNLDPGATVAEIKKQYRLLS 128

  Fly   130 KVLHPDKETGDEKSFMMLSKAYQALTDDVAKENYEKYGNPDGPGAMSFGIALPSWIVEKENSVWV 194
            ...|||| .|||..||.::|||.||||:.:::|:|::||||||.|.|||||||:|||:::||:.|
Mouse   129 LKYHPDK-GGDEVMFMRIAKAYAALTDEESRKNWEEFGNPDGPQATSFGIALPAWIVDQKNSILV 192

  Fly   195 LGLYGLVFMVAMPSAVGVWWYRSIRFSGDKVLLDTTQMYFYFIHKTPHMLLKRALMVLAASLEFD 259
            |.:|||.|||.:|..||.|||||||:|||::|:.|||:|.||::||.:|.:||.:||||.:.|||
Mouse   193 LLVYGLAFMVILPVVVGSWWYRSIRYSGDQILIRTTQIYTYFVYKTRNMDMKRLIMVLAGASEFD 257

  Fly   260 KRHNSQVQERQSDNDEVPALIRQLPNLNEKCKEHPLCRMYSIKARAILHAHLSRMPLNPETLERD 324
            .::|.....|.:||..:|.|||::.::|.|..|.||...||:|||.:|.:||:||.: |||||.|
Mouse   258 PQYNKDSTSRPTDNILIPQLIREIGSINLKKNEPPLTCPYSLKARVLLLSHLARMKI-PETLEED 321

  Fly   325 RQFVVKKCPYLVQEMVSCVHQLVMMAYAR--RVPRLPSIETIENCMKMSPMIIQGLWEFKSPLLQ 387
            :||::||||.|:||||:.:.||::||.:|  |..|.|::.::|||||:|.|.:|||.:|||||||
Mouse   322 QQFMLKKCPALLQEMVNVICQLIIMARSREEREFRAPTLASLENCMKLSQMAVQGLQQFKSPLLQ 386

  Fly   388 LPHLTEDHLYFM--NKKRHVKNLQQFAQLKPEESRQLLKNLSDFEYENTMKVLGKMPLIDFSIRC 450
            |||:.||:|..:  :||..:|.:|....||..:...||..|.|.:||..|.|||..|.:...|:.
Mouse   387 LPHIEEDNLRRVSNHKKYKIKTIQDLVSLKESDRHSLLHFLEDEKYEEVMAVLGSFPYVTMDIKS 451

  Fly   451 EVIDDENTNVVTAGAIVTVTVTLERKDMKTLFGDTK---APEKQGIKDETNEEAAGDEDEAAAAA 512
            :|:|||::|.:|.|::|||.|.|.|:.|..:|...:   |.|:|..:|       |..|    |.
Mouse   452 QVLDDEDSNNITVGSLVTVLVKLTRQTMAEVFEKEQSICAAEEQPTED-------GQSD----AN 505

  Fly   513 PVKKASAWAKPRKGGK--GKGGKK------------PAQNQKNQKKVPAKAATTATITASEDQAA 563
            .:|....|.:..||.|  .|..||            |...|:.||:......:.|.|...||..:
Mouse   506 KIKAKGGWQQKNKGPKKMPKSKKKKPLKKKPTTVPLPQAKQQKQKQANGVVGSEAAIKEEEDDIS 570

  Fly   564 AGNSDAESEAGN-------ADGSDVESAAGSGSEDEEKGKNNSSLDDDDDEEWERLQAKLNKRER 621
            ...||:|.|..|       .||||.||   ...:||::.|       ||:.||:.||..:.::||
Mouse   571 DKGSDSEEEETNRDSQSEKEDGSDRES---DREQDEKQSK-------DDEAEWQELQQSIQRKER 625

  Fly   622 --LEGKSRLSHTVHCPYFPEEKQEYWWTYICDRKSRTLLTAPYHVTNLVEKEEIQLKFTAPRWPG 684
              ||.||:::|.|:..||||||||:||.||.|||.:||::.||||..|.:.||::|||.||..||
Mouse   626 ALLETKSKITHPVYSLYFPEEKQEWWWLYIADRKEQTLISMPYHVCTLKDTEEVELKFPAPGKPG 690

  Fly   685 VYTFTVCLRSDSYLGMDQQQELKLDVQKAPAPPTDHPQWDLSESEPEHTDQQENLSDYTTDTSDE 749
            .|.:||.||||||:|:||.:.|||:|.:|...|.:|||||.:....|..:..|...|...:..:|
Mouse   691 NYQYTVFLRSDSYMGLDQIKPLKLEVHEAKPVPENHPQWDTAIEGDEDQEDSEGFEDSFEEEEEE 755

  Fly   750 EDG 752
            |:|
Mouse   756 EEG 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec63	NP_648111.1	DnaJ	105..164	CDD:278647	30/58 (52%)
		SEC63	211..709	CDD:214744	230/527 (44%)
		SEEEED	559..>626	CDD:291463	26/75 (35%)
Sec63	NP_694695.3	DnaJ	104..162	CDD:278647	29/57 (51%)
		SEC63	209..715	CDD:214744	234/535 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	492..617		40/145 (28%)
		SDA1	<563..>612	CDD:283052	18/55 (33%)
		SEEEED	564..>633	CDD:291463	27/77 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	720..760		11/33 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849596
Domainoid	1	1.000	225	1.000	Domainoid score	I2529
eggNOG	1	0.900	-	-		E1_COG5407
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5220
Inparanoid	1	1.050	638	1.000	Inparanoid score	I824
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56112
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003537
OrthoInspector	1	1.000	-	-		oto93506
orthoMCL	1	0.900	-	-		OOG6_102234
Panther	1	1.100	-	-	LDO	PTHR24075
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1312
SonicParanoid	1	1.000	-	-		X2413
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790