DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec63 and SEC63

DIOPT Version :9

Sequence 1:	NP_648111.1	Gene:	Sec63 / 38819	FlyBaseID:	FBgn0035771	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	NP_009145.1	Gene:	SEC63 / 11231	HGNCID:	21082	Length:	760	Species:	Homo sapiens

Alignment Length:	781	Identity:	341/781 - (43%)
Similarity:	487/781 - (62%)	Gaps:	50/781 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAGQKFQYDESGGTFYYFVLSFLALILIPTTIYYWPRKKKQDNSKLKEECQC-ADCQKKKTILAN 64
            ||||:||||:||.||:||:.||:.||:||.|.|.|||.:..:..:||...:. ..|...:..|..
Human     1 MAGQQFQYDDSGNTFFYFLTSFVGLIVIPATYYLWPRDQNAEQIRLKNIRKVYGRCMWYRLRLLK 65

  Fly    65 AEPYRALTSWTIKLTIVLGWALLLFLTYRVSQFDYEMASFDPFEILNVPPTSSQAEIKKAYYRLS 129
            .:|  .:.....|:.::.||||.|||.|:||:.|.|...::|:|:||:.|.::.|||||.|..||
Human    66 PQP--NIIPTVKKIVLLAGWALFLFLAYKVSKTDREYQEYNPYEVLNLDPGATVAEIKKQYRLLS 128

  Fly   130 KVLHPDKETGDEKSFMMLSKAYQALTDDVAKENYEKYGNPDGPGAMSFGIALPSWIVEKENSVWV 194
            ...|||| .|||..||.::|||.||||:.:::|:|::||||||.|.|||||||:|||:::||:.|
Human   129 LKYHPDK-GGDEVMFMRIAKAYAALTDEESRKNWEEFGNPDGPQATSFGIALPAWIVDQKNSILV 192

  Fly   195 LGLYGLVFMVAMPSAVGVWWYRSIRFSGDKVLLDTTQMYFYFIHKTPHMLLKRALMVLAASLEFD 259
            |.:|||.|||.:|..||.|||||||:|||::|:.|||:|.||::||.:|.:||.:||||.:.|||
Human   193 LLVYGLAFMVILPVVVGSWWYRSIRYSGDQILIRTTQIYTYFVYKTRNMDMKRLIMVLAGASEFD 257

  Fly   260 KRHNSQVQERQSDNDEVPALIRQLPNLNEKCKEHPLCRMYSIKARAILHAHLSRMPLNPETLERD 324
            .::|.....|.:||..:|.|||::.::|.|..|.||...||:|||.:|.:||:||.: |||||.|
Human   258 PQYNKDATSRPTDNILIPQLIREIGSINLKKNEPPLTCPYSLKARVLLLSHLARMKI-PETLEED 321

  Fly   325 RQFVVKKCPYLVQEMVSCVHQLVMMAYAR--RVPRLPSIETIENCMKMSPMIIQGLWEFKSPLLQ 387
            :||::||||.|:||||:.:.||::||..|  |..|.|::.::|||||:|.|.:|||.:|||||||
Human   322 QQFMLKKCPALLQEMVNVICQLIVMARNREEREFRAPTLASLENCMKLSQMAVQGLQQFKSPLLQ 386

  Fly   388 LPHLTEDHLYFM--NKKRHVKNLQQFAQLKPEESRQLLKNLSDFEYENTMKVLGKMPLIDFSIRC 450
            |||:.||:|..:  :||..:|.:|....||..:...||..|.|.:||..|.|||..|.:...|:.
Human   387 LPHIEEDNLRRVSNHKKYKIKTIQDLVSLKESDRHTLLHFLEDEKYEEVMAVLGSFPYVTMDIKS 451

  Fly   451 EVIDDENTNVVTAGAIVTVTVTLERKDMKTLFGDTK---APEKQGIKD---ETNEEAAGDEDEAA 509
            :|:|||::|.:|.|::|||.|.|.|:.|..:|...:   |.|:|..:|   |||:.
Human   452 QVLDDEDSNNITVGSLVTVLVKLTRQTMAEVFEKEQSICAAEEQPAEDGQGETNKN--------- 507

  Fly   510 AAAPVKKASAWAKPRKGGK--GKGGKK------------PAQNQKNQKKVPAKAATTATITASED 560
                 :....|.:..||.|  .|..||            |...|:.||:........|.:...|:
Human   508 -----RTKGGWQQKSKGPKKTAKSKKKKPLKKKPTPVLLPQSKQQKQKQANGVVGNEAAVKEDEE 567

  Fly   561 QAAAGNSDAESEAGNADG-SDVESAAGSGSEDEEKGKNNSSLDDDDDEEWERLQAKLNKRER--L 622
            :.:...||:|.|..|.|. |:.:..:...|:.|:..|.|.    ||:.||:.||..:.::||  |
Human   568 EVSDKGSDSEEEETNRDSQSEKDDGSDRDSDREQDEKQNK----DDEAEWQELQQSIQRKERALL 628

  Fly   623 EGKSRLSHTVHCPYFPEEKQEYWWTYICDRKSRTLLTAPYHVTNLVEKEEIQLKFTAPRWPGVYT 687
            |.||:::|.|:..||||||||:||.||.|||.:||::.||||..|.:.||::|||.||..||.|.
Human   629 ETKSKITHPVYSLYFPEEKQEWWWLYIADRKEQTLISMPYHVCTLKDTEEVELKFPAPGKPGNYQ 693

  Fly   688 FTVCLRSDSYLGMDQQQELKLDVQKAPAPPTDHPQWDLSESEPEHTDQQENLSDYTTDTSDEEDG 752
            :||.||||||:|:||.:.|||:|.:|...|.:|||||.:....|..:..|...|...:..:||:.
Human   694 YTVFLRSDSYMGLDQIKPLKLEVHEAKPVPENHPQWDTAIEGDEDQEDSEGFEDSFEEEEEEEED 758

  Fly   753 E 753
            :
Human   759 D 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec63	NP_648111.1	DnaJ	105..164	CDD:278647	30/58 (52%)
		SEC63	211..709	CDD:214744	224/524 (43%)
		SEEEED	559..>626	CDD:291463	22/69 (32%)
SEC63	NP_009145.1	DnaJ	104..162	CDD:395170	30/58 (52%)
		SEC63	209..715	CDD:214744	224/524 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	492..617		34/142 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	720..760		11/40 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159226
Domainoid	1	1.000	225	1.000	Domainoid score	I2552
eggNOG	1	0.900	-	-		E1_COG5407
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5220
Inparanoid	1	1.050	634	1.000	Inparanoid score	I835
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56112
OrthoDB	1	1.010	-	-		D176261at33208
OrthoFinder	1	1.000	-	-		FOG0003537
OrthoInspector	1	1.000	-	-		oto89930
orthoMCL	1	0.900	-	-		OOG6_102234
Panther	1	1.100	-	-	LDO	PTHR24075
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1312
SonicParanoid	1	1.000	-	-		X2413
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800