Protein Alignment Sec63 and sec63

DIOPT Version :10

• Sequence 1: NP_648111.1
• Gene: Sec63 / 38819
• FlyBaseID: FBgn0035771
• Length: 753
• Species: Drosophila melanogaster
• Sequence 2: XP_012819007.1
• Gene: sec63 / 100125094
• XenbaseID: XB-GENE-989521
• Length: 754
• Species: Xenopus tropicalis
• Alignment Length: 773
• Identity: 341/773 - (44%)
• Similarity: 494/773 - (63%)
• Gaps: 42/773 - (5%)

  Fly     1 MAGQKFQYDESGGTFYYFVLSFLALILIPTTIYYWPRKKKQDNSKLKEE------CQCADCQKKK 59
            ||||:||||:||.||:||:.||:.||:||.|.|.||:.|..:..:||.:      ||...
 Frog     1 MAGQQFQYDDSGNTFFYFLTSFVGLIVIPATYYLWPQDKNSEQIRLKNKRHVYRSCQWFQ----- 60

  Fly    60 TILANAEPYRALTSWTIKLTIVLGWALLLFLTYRVSQFDYEMASFDPFEILNVPPTSSQAEIKKA 124
              |...:|.|.:.....|:.::|||||.:||.|:||:.|.|...::|:|:|.:.|.::.:||:|.
 Frog    61 --LKLVKPQRNVVPTLKKIFLLLGWALFIFLAYKVSKTDREYQEYNPYEVLGLDPGATVSEIRKQ 123

  Fly   125 YYRLSKVLHPDKETGDEKSFMMLSKAYQALTDDVAKENYEKYGNPDGPGAMSFGIALPSWIVEKE 189
            |:.||:..|||| .|||..||.::|||.|||||.:::|:|::||||||.|.:||||||:|||:::
 Frog   124 YHHLSRKFHPDK-GGDEVMFMRIAKAYAALTDDESRKNWEEHGNPDGPQATTFGIALPAWIVDQK 187

  Fly   190 NSVWVLGLYGLVFMVAMPSAVGVWWYRSIRFSGDKVLLDTTQMYFYFIHKTPHMLLKRALMVLAA 254
            ||:.||.:|||.|||.:|..||.|||:|||:|||::|:.|||:|.||::||.:|.:||.:||||.
 Frog   188 NSMLVLLVYGLAFMVILPVVVGSWWYKSIRYSGDQILIRTTQIYTYFVYKTRNMDMKRLIMVLAG 252

  Fly   255 SLEFDKRHNSQVQERQSDNDEVPALIRQLPNLNEKCKEHPLCRMYSIKARAILHAHLSRMPLNPE 319
            :.|||.::|.....|.:||..:|.|||::.::|.|..|.||...||:|.|.:|.||||||.: ||
 Frog   253 ASEFDPQYNKDATSRPADNILIPQLIREIGSINLKKNEPPLTCPYSLKTRVLLLAHLSRMQI-PE 316

  Fly   320 TLERDRQFVVKKCPYLVQEMVSCVHQLVMMAYAR--RVPRLPSIETIENCMKMSPMIIQGLWEFK 382
            ||:.|:||::||||.|:||||:.:.||::||.:|  |..|.||:.::|||||:|.|.:|||.:||
 Frog   317 TLKDDQQFMLKKCPALLQEMVNVICQLIIMARSREERELRPPSLSSLENCMKLSQMTVQGLQQFK 381

  Fly   383 SPLLQLPHLTEDHLYFM--NKKRHVKNLQQFAQLKPEESRQLLKNLSDFEYENTMKVLGKMPLID 445
            |||||||.:.||||..:  :||..:|:::....:|..:.|.|...|.|..||..:.|||..|.|:
 Frog   382 SPLLQLPFIEEDHLRRVSNHKKFKIKSIRDLVSMKESDRRILFNFLEDSNYEELLAVLGSFPHIN 446

  Fly   446 FSIRCEVIDDENTNVVTAGAIVTVTVTLERKDMKTLF---GDTKAPEKQGIKDETNEEAAGDEDE 507
            ..|:.:|:|||::|.:|.|::|||.|.|:|:.|..:|   ..|.:.|.|.: ||...|....:..
 Frog   447 MEIKTQVLDDEDSNNITVGSLVTVLVVLKRQTMAEVFEKEQSTCSAEDQPV-DENQVEGGKTKKG 510

  Fly   508 AAAAAPVKKASAWAKPRKGGKGKGGKKPAQNQKNQKKVPAKAATTATITASEDQAAAGN--SDAE 570
            ........|.|:.:|.:|..|.|...:|...||..|:..|..|....:|..:|:..|.:  ||:|
 Frog   511 WQQKNKTAKKSSKSKKKKPPKKKPAAQPLPQQKQIKQKQANGAVLNDVTVKDDEEEASDKGSDSE 575

  Fly   571 SEAGNAD----GSDVESAAGSGSEDEEKGKNNSSLDDDDDEEWERLQAKLNKRER--LEGKSRLS 629
            .|..|.|    |||.:|   ....||:.||       ||:.||:.||..:.:::|  ||.||:::
 Frog   576 DEDQNRDSQSEGSDKDS---DRETDEKHGK-------DDEAEWQELQQSIQRKDRALLETKSKIT 630

  Fly   630 HTVHCPYFPEEKQEYWWTYICDRKSRTLLTAPYHVTNLVEKEEIQLKFTAPRWPGVYTFTVCLRS 694
            |:|:..||||||||:||.||.|||.:||::.|||:..|.::||::|||.||..||.|.:||.|||
 Frog   631 HSVYSLYFPEEKQEWWWIYIADRKDQTLISMPYHLCTLKDQEEVELKFPAPNKPGNYQYTVFLRS 695

  Fly   695 DSYLGMDQQQELKLDVQKAPAPPTDHPQWDLS-ESEPEHTDQQENLSDYTTDTSDEED 751
            |||:|:||.:.|||:|.:|...|.:|||||.: |.:.:..|.......|..:..|:||
 Frog   696 DSYMGLDQIKPLKLEVHEAKPIPENHPQWDTTIEGDDDQGDSDGFEESYDEEDDDDED 753

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec63	NP_648111.1	DnaJ	105..164	CDD:395170	28/58 (48%)
		SEC63	211..709	CDD:214744	224/512 (44%)
sec63	XP_012819007.1	DnaJ	104..162	CDD:395170	28/58 (48%)
		SEC63	209..710	CDD:214744	224/512 (44%)