DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec63 and sec63

DIOPT Version :9

Sequence 1:	NP_648111.1	Gene:	Sec63 / 38819	FlyBaseID:	FBgn0035771	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	XP_012819007.1	Gene:	sec63 / 100125094	XenbaseID:	XB-GENE-989521	Length:	754	Species:	Xenopus tropicalis

Alignment Length:	773	Identity:	341/773 - (44%)
Similarity:	494/773 - (63%)	Gaps:	42/773 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAGQKFQYDESGGTFYYFVLSFLALILIPTTIYYWPRKKKQDNSKLKEE------CQCADCQKKK 59
            ||||:||||:||.||:||:.||:.||:||.|.|.||:.|..:..:||.:      ||...
Frog     1 MAGQQFQYDDSGNTFFYFLTSFVGLIVIPATYYLWPQDKNSEQIRLKNKRHVYRSCQWFQ----- 60

  Fly    60 TILANAEPYRALTSWTIKLTIVLGWALLLFLTYRVSQFDYEMASFDPFEILNVPPTSSQAEIKKA 124
              |...:|.|.:.....|:.::|||||.:||.|:||:.|.|...::|:|:|.:.|.::.:||:|.
Frog    61 --LKLVKPQRNVVPTLKKIFLLLGWALFIFLAYKVSKTDREYQEYNPYEVLGLDPGATVSEIRKQ 123

  Fly   125 YYRLSKVLHPDKETGDEKSFMMLSKAYQALTDDVAKENYEKYGNPDGPGAMSFGIALPSWIVEKE 189
            |:.||:..|||| .|||..||.::|||.|||||.:::|:|::||||||.|.:||||||:|||:::
Frog   124 YHHLSRKFHPDK-GGDEVMFMRIAKAYAALTDDESRKNWEEHGNPDGPQATTFGIALPAWIVDQK 187

  Fly   190 NSVWVLGLYGLVFMVAMPSAVGVWWYRSIRFSGDKVLLDTTQMYFYFIHKTPHMLLKRALMVLAA 254
            ||:.||.:|||.|||.:|..||.|||:|||:|||::|:.|||:|.||::||.:|.:||.:||||.
Frog   188 NSMLVLLVYGLAFMVILPVVVGSWWYKSIRYSGDQILIRTTQIYTYFVYKTRNMDMKRLIMVLAG 252

  Fly   255 SLEFDKRHNSQVQERQSDNDEVPALIRQLPNLNEKCKEHPLCRMYSIKARAILHAHLSRMPLNPE 319
            :.|||.::|.....|.:||..:|.|||::.::|.|..|.||...||:|.|.:|.||||||.: ||
Frog   253 ASEFDPQYNKDATSRPADNILIPQLIREIGSINLKKNEPPLTCPYSLKTRVLLLAHLSRMQI-PE 316

  Fly   320 TLERDRQFVVKKCPYLVQEMVSCVHQLVMMAYAR--RVPRLPSIETIENCMKMSPMIIQGLWEFK 382
            ||:.|:||::||||.|:||||:.:.||::||.:|  |..|.||:.::|||||:|.|.:|||.:||
Frog   317 TLKDDQQFMLKKCPALLQEMVNVICQLIIMARSREERELRPPSLSSLENCMKLSQMTVQGLQQFK 381

  Fly   383 SPLLQLPHLTEDHLYFM--NKKRHVKNLQQFAQLKPEESRQLLKNLSDFEYENTMKVLGKMPLID 445
            |||||||.:.||||..:  :||..:|:::....:|..:.|.|...|.|..||..:.|||..|.|:
Frog   382 SPLLQLPFIEEDHLRRVSNHKKFKIKSIRDLVSMKESDRRILFNFLEDSNYEELLAVLGSFPHIN 446

  Fly   446 FSIRCEVIDDENTNVVTAGAIVTVTVTLERKDMKTLF---GDTKAPEKQGIKDETNEEAAGDEDE 507
            ..|:.:|:|||::|.:|.|::|||.|.|:|:.|..:|   ..|.:.|.|.: ||...|....:..
Frog   447 MEIKTQVLDDEDSNNITVGSLVTVLVVLKRQTMAEVFEKEQSTCSAEDQPV-DENQVEGGKTKKG 510

  Fly   508 AAAAAPVKKASAWAKPRKGGKGKGGKKPAQNQKNQKKVPAKAATTATITASEDQAAAGN--SDAE 570
            ........|.|:.:|.:|..|.|...:|...||..|:..|..|....:|..:|:..|.:  ||:|
Frog   511 WQQKNKTAKKSSKSKKKKPPKKKPAAQPLPQQKQIKQKQANGAVLNDVTVKDDEEEASDKGSDSE 575

  Fly   571 SEAGNAD----GSDVESAAGSGSEDEEKGKNNSSLDDDDDEEWERLQAKLNKRER--LEGKSRLS 629
            .|..|.|    |||.:|   ....||:.||       ||:.||:.||..:.:::|  ||.||:::
Frog   576 DEDQNRDSQSEGSDKDS---DRETDEKHGK-------DDEAEWQELQQSIQRKDRALLETKSKIT 630

  Fly   630 HTVHCPYFPEEKQEYWWTYICDRKSRTLLTAPYHVTNLVEKEEIQLKFTAPRWPGVYTFTVCLRS 694
            |:|:..||||||||:||.||.|||.:||::.|||:..|.::||::|||.||..||.|.:||.|||
Frog   631 HSVYSLYFPEEKQEWWWIYIADRKDQTLISMPYHLCTLKDQEEVELKFPAPNKPGNYQYTVFLRS 695

  Fly   695 DSYLGMDQQQELKLDVQKAPAPPTDHPQWDLS-ESEPEHTDQQENLSDYTTDTSDEED 751
            |||:|:||.:.|||:|.:|...|.:|||||.: |.:.:..|.......|..:..|:||
Frog   696 DSYMGLDQIKPLKLEVHEAKPIPENHPQWDTTIEGDDDQGDSDGFEESYDEEDDDDED 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec63	NP_648111.1	DnaJ	105..164	CDD:278647	28/58 (48%)
		SEC63	211..709	CDD:214744	224/512 (44%)
		SEEEED	559..>626	CDD:291463	25/74 (34%)
sec63	XP_012819007.1	DnaJ	104..162	CDD:365959	28/58 (48%)
		SEC63	209..710	CDD:214744	224/512 (44%)
		MSCRAMM_SdrC	<556..628	CDD:380146	27/81 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	222	1.000	Domainoid score	I2536
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H5220
Inparanoid	1	1.050	634	1.000	Inparanoid score	I825
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D176261at33208
OrthoFinder	1	1.000	-	-		FOG0003537
OrthoInspector	1	1.000	-	-		otm48497
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1312
SonicParanoid	1	1.000	-	-		X2413
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.090