DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CTCF and ZBTB40

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_001077090.1	Gene:	ZBTB40 / 9923	HGNCID:	29045	Length:	1239	Species:	Homo sapiens

Alignment Length:	657	Identity:	139/657 - (21%)
Similarity:	218/657 - (33%)	Gaps:	206/657 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TKKDEDPEDLQTFLNNFHKEIEGNSDEKVVNTILEAISAEAIDLDENGAEAGGSKPMEEAEADLD 69
            ||:|.:.|..:. .|.||.|.....|||...
Human   671 TKEDGEKETWKV-SNKFHLEANNKEDEKAAK---------------------------------- 700

  Fly    70 HAEEAEEEEEDDEDKYFIDDEGNCYIKTTPKKQKELQKKLKQAAAKPGKATRSVVSTATNKSINL 134
              |:::..|::|:.:          ..:.|.:|:      |:|:|.|..|.:|.:..|.:||.:.
Human   701 --EDSQPGEQNDQGE----------TGSLPGQQE------KEASASPDPAKKSFICKACDKSFHF 747

  Fly   135 RPAKSTPKATTSKPPPEPKAISVRPARAAAAKAKQSAMPPPPALVVKVPAPRGRPRKNPVIPKPE 199
            .                 ..:.|...|...||:||...
Human   748 Y-----------------CRLKVHMKRCRVAKSKQVQC--------------------------- 768

  Fly   200 PMDLERELEELVDEPDISSMVTELSDYTVDEAAVEAATATLTPNEAEVYEFEDNATTEDENADKK 264
                 :|..|..|                            :..|.:.::.|.:....:.:|.||
Human   769 -----KECSETKD----------------------------SKKELDKHQLEAHGAGGEPDAPKK 800

  Fly   265 DVDFVLSNKEVKLKTASSTSQNSNASGHKYSCPHCPYTASKKFLITRHSRSHDVEPSFKCSICER 329
                  ..|.:.:.......:.::|||.:|            ..:|.|   .|.:| |.|..|..
Human   801 ------KKKRLPVTCDLCGREFAHASGMQY------------HKLTEH---FDEKP-FSCEECGA 843

  Fly   330 SFRSNVGLQNHINTHMGNKPHKCKLCESAFTTSGELVRHTRYKHTKEKPHKCTECTYASVELTKL 394
            .|.:|..|:||:..|.|::|..||.|...||.:..|..||:.||::.|.:.|..|.....:..:|
Human   844 KFAANSTLKNHLRLHTGDRPFMCKHCLMTFTQASALAYHTKKKHSEGKMYACQYCDAVFAQSIEL 908

  Fly   395 RRHMTCHTGERPYQCPHCTYASQDMFKLKRHM-VIHTGEKKYQCDICKSRFTQSNSLKAH-KLIH 457
            .||:..|||::||.|..|....:....|..|: ..|..|..|.|..|:..|.   :|:.| |.||
Human   909 SRHVRTHTGDKPYVCRDCGKGFRQANGLSIHLHTFHNIEDPYDCKKCRMSFP---TLQDHRKHIH 970

  Fly   458 SVVDKPVFQCNYC---------------------PTTCG-------RKADLRVHIKHMHTSDV-- 492
            .|..|....|..|                     |.:||       :.:.|..| ...|..||
Human   971 EVHSKEYHPCPTCGKIFSAPSMLERHVVTHVGGKPFSCGICNKAYQQLSGLWYH-NRTHHPDVFA 1034

  Fly   493 ----------PMTCRRCGQQLPDRYQYKLHVKS-HEGEKCYSCKLCSYASVTQRHLASHMLI-HL 545
                      .:.|..|.:..|:..::|.|:|: |...|.:.|..|.....|...|..|:.. |.
Human  1035 AQNHRSSKFSSLQCSSCDKTFPNTIEHKKHIKAEHADMKFHECDQCKELFPTPALLQVHVKCQHS 1099

  Fly   546 DEKPFHCDQCPQAFRQRQLLRRHMNLVHNEEYQPPEPREKLHKCPSCPREFTHKGNLMRHMETHD 610
            ..:||.|..|...||....|:.|:...|.::.:...|      |..|...||.:..|..|:|:..
Human  1100 GSQPFRCLYCAATFRFPGALQHHVTTEHFKQSETTFP------CELCGELFTSQAQLDSHLESEH 1158

  Fly   611 DSANARE 617
            ....:.|
Human  1159 PKVMSTE 1165

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226	12/89 (13%)
		C2H2 Zn finger	296..316	CDD:275368	2/19 (11%)
		COG5048	321..>621	CDD:227381	91/341 (27%)
		zf-C2H2	322..344	CDD:278523	8/21 (38%)
		C2H2 Zn finger	324..344	CDD:275368	7/19 (37%)
		zf-H2C2_2	337..361	CDD:290200	10/23 (43%)
		C2H2 Zn finger	352..373	CDD:275368	8/20 (40%)
		C2H2 Zn finger	381..401	CDD:275368	5/19 (26%)
		zf-H2C2_2	394..415	CDD:290200	10/20 (50%)
		C2H2 Zn finger	409..429	CDD:275368	4/20 (20%)
		zf-H2C2_2	422..446	CDD:290200	8/24 (33%)
		C2H2 Zn finger	437..457	CDD:275368	6/20 (30%)
		C2H2 Zn finger	467..485	CDD:275368	7/45 (16%)
		C2H2 Zn finger	496..516	CDD:275370	6/20 (30%)
		C2H2 Zn finger	524..544	CDD:275368	5/20 (25%)
		zf-H2C2_2	536..561	CDD:290200	8/25 (32%)
		C2H2 Zn finger	552..573	CDD:275368	6/20 (30%)
		zf-C2H2	587..609	CDD:278523	7/21 (33%)
		C2H2 Zn finger	589..609	CDD:275368	7/19 (37%)
ZBTB40	NP_001077090.1	BTB	19..113	CDD:279045
		BTB	25..113	CDD:197585
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	130..231
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	687..732		14/96 (15%)
		C2H2 Zn finger	768..789	CDD:275368	5/80 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	779..801		5/27 (19%)
		COG5048	<794..970	CDD:227381	57/200 (29%)
		C2H2 Zn finger	809..830	CDD:275368	5/32 (16%)
		C2H2 Zn finger	838..858	CDD:275368	7/19 (37%)
		zf-H2C2_2	851..875	CDD:290200	10/23 (43%)
		C2H2 Zn finger	866..915	CDD:275368	16/48 (33%)
		zf-H2C2_2	907..932	CDD:290200	10/24 (42%)
		C2H2 Zn finger	923..942	CDD:275368	4/18 (22%)
		C2H2 Zn finger	952..970	CDD:275370	6/20 (30%)
		C2H2 Zn finger	1008..1028	CDD:275368	4/20 (20%)
		C2H2 Zn finger	1048..1066	CDD:275368	5/17 (29%)
		C2H2 Zn finger	1077..1098	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1106..1127	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1137..1154	CDD:275368	5/16 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000