Protein Alignment CTCF and ZNF160

DIOPT Version :10

• Sequence 1: NP_648109.1
• Gene: CTCF / 38817
• FlyBaseID: FBgn0035769
• Length: 818
• Species: Drosophila melanogaster
• Sequence 2: XP_047295573.1
• Gene: ZNF160 / 90338
• HGNCID: 12948
• Length: 837
• Species: Homo sapiens
• Alignment Length: 334
• Identity: 117/334 - (35%)
• Similarity: 159/334 - (47%)
• Gaps: 21/334 - (6%)

  Fly   284 SQNSNASGHK--------YSCPHCPYTASKKFLITRHSRSHDVEPSFKCSICERSFRSNVGLQNH 340
            :|||..:.|:        |.|..|....|.:..:|.|...|..|..:||..|.:||.....|::|
Human   510 TQNSQLANHRRIHTGEKPYKCNECGKAFSVRSSLTTHQAIHSGEKPYKCIECGKSFTQKSHLRSH 574

  Fly   341 INTHMGNKPHKCKLCESAFTTSGELVRHTRYKHTKEKPHKCTECTYASVELTKLRRHMTCHTGER 405
            ...|.|.||:||..|...|..:.:|.||.|. ||.|||:||.:|..|..:.:.|..|...||||:
Human   575 RGIHSGEKPYKCNECGKVFAQTSQLARHWRV-HTGEKPYKCNDCGRAFSDRSSLTFHQAIHTGEK 638

  Fly   406 PYQCPHCTYASQDMFKLKRHMVIHTGEKKYQCDICKSRFTQSNSLKAHKLIHSVVDKPVFQCNYC 470
            ||:|..|....:....|..|..||||||.|:|:.|...|:..::|..||:||: .:|| ::||.|
Human   639 PYKCHECGKVFRHNSYLATHRRIHTGEKPYKCNECGKAFSMHSNLTTHKVIHT-GEKP-YKCNQC 701

  Fly   471 PTTCGRKADLRVHIKHMHTSDVPMTCRRCGQQLPDRYQYKLHVKSHEGEKCYSCKLCSYASVTQR 535
            .....:.:.|..| :..||.:.|..|..||:....|.....|...|.|:|.|.|..|........
Human   702 GKVFTQNSHLANH-QRTHTGEKPYRCNECGKAFSVRSSLTTHQAIHTGKKPYKCNECGKVFTQNA 765

  Fly   536 HLASHMLIHLDEKPFHCDQCPQAFRQRQLLRRHMNLVHNEEYQPPEPREKLHKCPSCPREFTHKG 600
            |||:|..||..|||:.|.:|.:|||.|..|..|| .:|.        .||.:||..|.:.|....
Human   766 HLANHRRIHTGEKPYRCTECGKAFRVRSSLTTHM-AIHT--------GEKRYKCNECGKVFRQSS 821

  Fly   601 NLMRHMETH 609
            ||..|...|
Human   822 NLASHHRMH 830

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	FAP	116..>202	CDD:429334
		C2H2 Zn finger	296..316	CDD:275368	5/19 (26%)
		COG5048	321..>621	CDD:227381	105/289 (36%)
		C2H2 Zn finger	324..344	CDD:275368	6/19 (32%)
		C2H2 Zn finger	352..373	CDD:275368	7/20 (35%)
		C2H2 Zn finger	381..401	CDD:275368	5/19 (26%)
		zf-H2C2_2	394..415	CDD:463886	10/20 (50%)
		C2H2 Zn finger	409..429	CDD:275368	4/19 (21%)
		zf-H2C2_2	422..446	CDD:463886	12/23 (52%)
		C2H2 Zn finger	437..457	CDD:275368	6/19 (32%)
		C2H2 Zn finger	467..485	CDD:275368	5/17 (29%)
		C2H2 Zn finger	496..516	CDD:275370	5/19 (26%)
		C2H2 Zn finger	524..544	CDD:275368	6/19 (32%)
		zf-H2C2_2	536..561	CDD:463886	13/24 (54%)
		C2H2 Zn finger	552..573	CDD:275368	9/20 (45%)
		zf-C2H2	587..609	CDD:395048	7/21 (33%)
		C2H2 Zn finger	589..609	CDD:275368	6/19 (32%)
ZNF160	XP_047295573.1	KRAB	27..87	CDD:214630
		SFP1	<235..351	CDD:227516
		C2H2 Zn finger	278..298	CDD:275368
		zf-H2C2_2	290..314	CDD:463886
		C2H2 Zn finger	306..326	CDD:275368
		C2H2 Zn finger	334..354	CDD:275368
		zf-H2C2_2	346..369	CDD:463886
		C2H2 Zn finger	362..382	CDD:275368
		COG5048	386..829	CDD:227381	116/331 (35%)
		C2H2 Zn finger	390..410	CDD:275368
		C2H2 Zn finger	418..438	CDD:275368
		C2H2 Zn finger	446..466	CDD:275368
		C2H2 Zn finger	474..494	CDD:275368
		C2H2 Zn finger	502..522	CDD:275368	4/11 (36%)
		C2H2 Zn finger	530..550	CDD:275368	5/19 (26%)
		C2H2 Zn finger	558..578	CDD:275368	6/19 (32%)
		C2H2 Zn finger	586..606	CDD:275368	7/20 (35%)
		C2H2 Zn finger	614..634	CDD:275368	5/19 (26%)
		C2H2 Zn finger	642..662	CDD:275368	4/19 (21%)
		C2H2 Zn finger	670..690	CDD:275368	6/19 (32%)
		C2H2 Zn finger	698..718	CDD:275368	5/20 (25%)
		C2H2 Zn finger	726..746	CDD:275368	5/19 (26%)
		C2H2 Zn finger	754..774	CDD:275368	6/19 (32%)
		C2H2 Zn finger	782..802	CDD:275368	9/20 (45%)
		C2H2 Zn finger	810..830	CDD:275368	6/19 (32%)