DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CTCF and AZF1

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_014756.3	Gene:	AZF1 / 854280	SGDID:	S000005639	Length:	914	Species:	Saccharomyces cerevisiae

Alignment Length:	924	Identity:	181/924 - (19%)
Similarity:	319/924 - (34%)	Gaps:	236/924 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 TFLNNFHKEIEGNSDEKVVNTILEAISAEAIDLDENGAEAGGSKPMEEAEADLDHAEEAEEEEED 80
            ::..||::  ...|.:..:|:.|. ||.........|..:||      |.::|.....:...:..
Yeast    63 SYYTNFNQ--PRYSTDASINSFLN-ISDNVPVTSTGGPSSGG------AYSNLPRLSTSSTHQPP 118

  Fly    81 DEDKYFIDDEGNCYIKTTPKKQKEL--------QKKLKQAAAKPGKATRSVVS--TATNKSINLR 135
            |..:.   ..|...:.....:|::|        |::.:|:..:|...|.|..:  |.::......
Yeast   119 DLSQI---GRGFSIVNNLFPQQQQLQNQHRQQQQQQQQQSHQQPPFKTPSFSTGLTGSSSQYQFL 180

  Fly   136 PAKSTPKATTSKPPPEPKAI-----------------SVRPARAAAAKAKQSAMPPP---PALVV 180
            |...    .||:||.:..::                 |.:|....:::.:.::|.||   ||...
Yeast   181 PRND----NTSQPPSKRNSVYLGPNDGPDFEFFSMQQSQQPQFQPSSRRESNSMRPPLLIPAATT 241

  Fly   181 KVPA---------------------------PRGRP-----RKNPVIPKPEPMDLERE-----LE 208
            |..:                           ....|     |.|.:...||..|.:.:     :.
Yeast   242 KSQSNGTNNSGNMNTNADYESFFNTGTNNSNSNQNPYFLSSRNNSLKFNPEDFDFQFKRRNSFVR 306

  Fly   209 ELVDEPDISSMVTE--LSDYTVDEAA-----VEAATATLTPNEAEVYEFE------DNATTEDEN 260
            ..:|....::.:.|  |:..:|:..|     .:..|..:.....||...:      :|....:.|
Yeast   307 GTLDHSSQNAFIPESRLNSLSVNNKANGDPVADNVTNNMKGKSNEVDNDDGNDSSNNNNNNNNNN 371

  Fly   261 ADKKDVDFVLSNKEVKLKTASSTSQNSNASGHKYSCPHCPYTASKKFL--ITRHSRSH-DVEPSF 322
            .::.:.|....|.:..:.:|:||: ..|...|..:..... :.|:|.|  |.:..|.| :.|.::
Yeast   372 NNENNNDNNNDNNDNSINSATSTN-IPNQEDHSLASTDTT-SNSRKDLKEIEQRLRKHLNDEDNY 434

  Fly   323 KCSICERSFRSNV-----GLQNHINTHMGNKPH---KCKLCESAFTTSGELVRHTRYKHTKEKPH 379
            ..:|.....:::|     ||..||: ..|.:|:   |.|..:|......|:.|       .:.|.
Yeast   435 SSAISRPLDKNDVIEGSEGLNKHID-ESGMQPNIIKKRKKDDSTVYVKNEMPR-------TDPPM 491

  Fly   380 KCTECTYASVELTKLRRHMTCHTGERPYQCPHCTYASQD------MFKLKRHMVIHTGEKKYQCD 438
            .....|.|.      ...|...:|:.| ..|..:..|.|      ..|:.:.|:|....||...:
Yeast   492 SKDNSTSAE------GAAMANFSGKEP-PIPDISSVSDDATNLIGATKVDQLMLIIQARKKGFTE 549

  Fly   439 ICKSRFTQSNSLKAHKLIHSV---------VDKP----------VFQCNYCPTTCGRKADLRVHI 484
              |...||...|..::.:..:         |:||          ..:|.||.....:...|.||:
Yeast   550 --KVNTTQDGDLLFNQTMDILPPKSELVGGVEKPKGTQNTRAVKKHECPYCHRLFSQATHLEVHV 612

  Fly   485 KHMHTSDVPMTCRRCGQQLPDRYQYKLHVKSHEGEKCYSCKLCSYASVTQRHLASHMLIHLDEKP 549
            : .|....|..|..||::.......:.|.:.|.|||.|||.:|......:.:||:|::.|...||
Yeast   613 R-SHIGYKPFVCDYCGKRFTQGGNLRTHERLHTGEKPYSCDICDKKFSRKGNLAAHLVTHQKLKP 676

  Fly   550 FHC--DQCPQAFRQRQLLRRHMNLVHNE----------EYQPPEPREKLHKCPSCPREFTHKGNL 602
            |.|  :.|.:.|.|...::.|.|..|.|          |..|.|         :.|.|   :..|
Yeast   677 FVCKLENCNKTFTQLGNMKAHQNRFHKETLNALTAKLAEMNPSE---------NIPLE---ERQL 729

  Fly   603 MRHMETHDDSANAREKRRRLKLGRNVRLQKD----------GTVITLIKDQYVDMDRDQEEN--- 654
            :.:..:...::|...|.|    |:.|..:|.          .|::....:....:..|.|.|
Yeast   730 LEYFASIYKNSNRGIKGR----GKGVGTKKSTISSPENHPASTILNPNTNANNAIANDSENNGNP 790

  Fly   655 ------EEDDNPESYDLAEIEPENSEAEDADDDVETIVSDPIRQRIKPAPIIINKQARLAASEKQ 713
                  ..:.||.|:.:  |.|       ...|:.|:.|..|:..       .|.....:....|
Yeast   791 EGNIDSSSNSNPGSHSM--ISP-------TQKDMGTLQSQFIQNN-------FNNSVNSSNPSNQ 839

  Fly   714 PMIIN--------QRLRSQRGTKTFHIKEEPDNSDFTVEWQGDDGEVMVVELVNGDEEVLV---- 766
            | |||        .||.|...:.|     ..:||:|:|   |....|::....|.|....:
Yeast   840 P-IINYNYTTLPHSRLGSSSSSNT-----NNNNSNFSV---GAAPGVLMAPTTNNDFSFNLDQSN 895

  Fly   767 KHEPSANSKISAKN 780
            .:|.|...::..||
Yeast   896 DNERSQQEQVRFKN 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226	23/143 (16%)
		C2H2 Zn finger	296..316	CDD:275368	5/21 (24%)
		COG5048	321..>621	CDD:227381	77/344 (22%)
		zf-C2H2	322..344	CDD:278523	6/26 (23%)
		C2H2 Zn finger	324..344	CDD:275368	6/24 (25%)
		zf-H2C2_2	337..361	CDD:290200	8/26 (31%)
		C2H2 Zn finger	352..373	CDD:275368	4/20 (20%)
		C2H2 Zn finger	381..401	CDD:275368	3/19 (16%)
		zf-H2C2_2	394..415	CDD:290200	4/20 (20%)
		C2H2 Zn finger	409..429	CDD:275368	5/25 (20%)
		zf-H2C2_2	422..446	CDD:290200	5/23 (22%)
		C2H2 Zn finger	437..457	CDD:275368	4/19 (21%)
		C2H2 Zn finger	467..485	CDD:275368	6/17 (35%)
		C2H2 Zn finger	496..516	CDD:275370	4/19 (21%)
		C2H2 Zn finger	524..544	CDD:275368	5/19 (26%)
		zf-H2C2_2	536..561	CDD:290200	10/26 (38%)
		C2H2 Zn finger	552..573	CDD:275368	6/22 (27%)
		zf-C2H2	587..609	CDD:278523	3/21 (14%)
		C2H2 Zn finger	589..609	CDD:275368	3/19 (16%)
AZF1	NP_014756.3	COG5048	342..768	CDD:227381	100/461 (22%)
		C2H2 Zn finger	595..615	CDD:275368	6/20 (30%)
		C2H2 Zn finger	623..643	CDD:275368	4/19 (21%)
		C2H2 Zn finger	651..671	CDD:275368	5/19 (26%)
		C2H2 Zn finger	679..702	CDD:275368	6/22 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010