DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CTCF and STP3

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_013479.3	Gene:	STP3 / 851089	SGDID:	S000004367	Length:	343	Species:	Saccharomyces cerevisiae

Alignment Length:	364	Identity:	79/364 - (21%)
Similarity:	142/364 - (39%)	Gaps:	96/364 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 PDISSM--VTELSDYTVDEAAVEAATATLTPN------------EAEVYEFEDNATTEDENADKK 264
            |.|||.  :.:.::...:..|..|:|....||            .:.:..::....:.|.:....
Yeast    15 PPISSFDNLIKAAERQYNGEASSASTHPTLPNMNISNGSGSAGASSSMLSYQLLPHSNDVSRSNS 79

  Fly   265 DVDFVLSNKEVKLKTASSTSQNSNASGHKYSCPHC----PYTASKKFLITRHSRSHDVEPSFK-- 323
            ...|:.|.::....:||::..:|:||..:...|..    |.:.....:.|.||...: :|..|
Yeast    80 SSSFLPSVQQPTEGSASASETSSSASPSRSISPILKVAGPSSVGGAGVSTPHSTKIN-KPRKKKQ 143

  Fly   324 CSICERSFRSNVGLQNHINTHM--GNKPHKCKLCESAFTTSGELVRHTRYKHTKEK--------- 377
            |.|| |:|.:|  |..|..||:  .::||||.:|...|..:.:|:||.: :|.|::
Yeast   144 CPIC-RNFYAN--LTTHKATHLTPEDRPHKCPICHRGFARNNDLLRHKK-RHWKDEILSQSGVLS 204

  Fly   378 -----------PH------KCTECTYASVELTKLRRHMTCHTGERPYQCP-HCTYASQDM----F 420
                       |:      |.|...    .:|...:..:.|..:..::|| :.|....||    :
Yeast   205 NHNDGKGGSVSPNDDDTHEKMTPMN----SVTDYAQLKSLHQIKGTFKCPFNSTLIQLDMDMYPY 265

  Fly   421 KLKRHMVIHTGEKKYQCDICKSR--FTQSNSLKAH-KLIHSVVDKPVFQCNYCPTTCGRKADLRV 482
            |||        ...::...|...  |::.::.|.| |.:|       |:  |.|.|  :|.|..|
Yeast   266 KLK--------PLNFETSNCHQTGVFSRCDTFKNHLKALH-------FE--YPPGT--KKKDRNV 311

  Fly   483 HIKHMHTSDVPMTCRRCGQQLPDRYQYKLHVKSHEGEKC 521
                     ||..|:.||.:..:   ..:.:..|.|::|
Yeast   312 ---------VPGRCKHCGLKFEN---VDVWLNEHVGKQC 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226
		C2H2 Zn finger	296..316	CDD:275368	5/23 (22%)
		COG5048	321..>621	CDD:227381	56/239 (23%)
		zf-C2H2	322..344	CDD:278523	9/23 (39%)
		C2H2 Zn finger	324..344	CDD:275368	8/19 (42%)
		zf-H2C2_2	337..361	CDD:290200	10/25 (40%)
		C2H2 Zn finger	352..373	CDD:275368	6/20 (30%)
		C2H2 Zn finger	381..401	CDD:275368	2/19 (11%)
		zf-H2C2_2	394..415	CDD:290200	4/21 (19%)
		C2H2 Zn finger	409..429	CDD:275368	8/24 (33%)
		zf-H2C2_2	422..446	CDD:290200	4/25 (16%)
		C2H2 Zn finger	437..457	CDD:275368	5/22 (23%)
		C2H2 Zn finger	467..485	CDD:275368	6/17 (35%)
		C2H2 Zn finger	496..516	CDD:275370	3/19 (16%)
		C2H2 Zn finger	524..544	CDD:275368
		zf-H2C2_2	536..561	CDD:290200
		C2H2 Zn finger	552..573	CDD:275368
		zf-C2H2	587..609	CDD:278523
		C2H2 Zn finger	589..609	CDD:275368
STP3	NP_013479.3	COG5048	<137..295	CDD:227381	40/173 (23%)
		C2H2 Zn finger	144..161	CDD:275368	8/19 (42%)
		C2H2 Zn finger	171..191	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100