DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CTCF and AT3G29340

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_189580.1	Gene:	AT3G29340 / 822592	AraportID:	AT3G29340	Length:	650	Species:	Arabidopsis thaliana

Alignment Length:	549	Identity:	106/549 - (19%)
Similarity:	177/549 - (32%)	Gaps:	188/549 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   321 SFKCSICERSFRSNVGLQNHINTHMGNKPHKCKLCESAFTTSGELVRHTRYKHTKEKPHKCTECT 385
            |.||.||.:||.....|..|...|   :|.|.||.:..|  |....|.::.:...|....|.||.
plant    42 SHKCKICGKSFECYQALGGHQRIH---RPIKEKLSKQEF--SEVYPRKSKLQKRPESSSSCYECK 101

  Fly   386 YASVELTKLRRHMTCHTGERPYQCPHCTYASQDMFKLKRHMVIHTGEKKYQCDICKSRFTQSNSL 450
            ...       :...|:.|                  |..|..:|...|:   ::..::  ..|||
plant   102 VCG-------KIFGCYRG------------------LGGHTKLHRSTKR---ELASTQ--DENSL 136

  Fly   451 KAHKLIHSVVDKP-VFQCN------YCPTTCGRKADLRVHIKH------MHTSDVPMTCRRCGQQ 502
            ........:|.:| .|:.:      :|           |.:|.      .|:..:|.|.|.
plant   137 LDSSEAKKIVSQPSSFKVSQEEKFLHC-----------VELKQDFSEPLSHSGALPSTLRS---- 186

  Fly   503 LPDRYQYKLHVKSHEGEKCYSCKLCSYASVTQRHLASHMLIH----------------------- 544
                   ||..|:.....|: ||:|..:.|..:.|.:|..:|
plant   187 -------KLQTKTQWKSSCH-CKICGKSFVCSQGLGNHKRVHREISGKLACKRKYTEDYNPFSDS 243

  Fly   545 ----------------LDEKPFHCDQ-------------------CPQAFRQRQLLRRHMNLVHN 574
                            .:||..||.:                   |.::.:.:::.|:      |
plant   244 LKAKKIVKKPSSFEVSQEEKILHCVELKQDFGELLAHSGFDKSISCSKSIKVKKVARK------N 302

  Fly   575 EEYQPP---------EPREKLHKCPSCPREF-THKGNLMRHMETHDDSANAREKRRRLKLGRNVR 629
            |:.:..         |..::||.|.:|.|:| |.|| :..|...|..:.|..|....|:  |...
plant   303 EKTEDSTSLFGVFVGEMSQRLHGCKTCGRKFGTLKG-VYGHQRMHSGNHNRIEDENGLE--RIWG 364

  Fly   630 LQKDGTVITLIKDQYVDMDRDQEENEEDDNPES-----------YDLAEIEPENSEAEDADDDVE 683
            |:|...|.::.............|.|:.:..|:           ||.|.|  .|....|...|:|
plant   365 LKKKSRVCSVSAFDRFKGSSFMAEIEKHEVIEAALNLVMLCQGVYDFASI--SNLPLGDGFMDLE 427

  Fly   684 TIVSDPIRQRIKPAPIIINKQARLAASEK-----QPMIINQRLRSQRGTKTFHIKEEPDNSDFTV 743
                      :||.|:....|.:..:|.|     :..:.:|.|.|.:....:.:..:|
plant   428 ----------LKPCPLRRKLQKKSRSSYKCSICEKSFVCSQALGSHQRLHRWKLVPKP------- 475

  Fly   744 EWQGDDGEVMVVELVNGDEEVLVKHEPSA 772
            |:..||.     .|::..|...:..:||:
plant   476 EYIEDDS-----SLLDSSEAKKIVSKPSS 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226
		C2H2 Zn finger	296..316	CDD:275368
		COG5048	321..>621	CDD:227381	73/380 (19%)
		zf-C2H2	322..344	CDD:278523	8/21 (38%)
		C2H2 Zn finger	324..344	CDD:275368	7/19 (37%)
		zf-H2C2_2	337..361	CDD:290200	8/23 (35%)
		C2H2 Zn finger	352..373	CDD:275368	5/20 (25%)
		C2H2 Zn finger	381..401	CDD:275368	3/19 (16%)
		zf-H2C2_2	394..415	CDD:290200	2/20 (10%)
		C2H2 Zn finger	409..429	CDD:275368	2/19 (11%)
		zf-H2C2_2	422..446	CDD:290200	4/23 (17%)
		C2H2 Zn finger	437..457	CDD:275368	3/19 (16%)
		C2H2 Zn finger	467..485	CDD:275368	2/23 (9%)
		C2H2 Zn finger	496..516	CDD:275370	4/19 (21%)
		C2H2 Zn finger	524..544	CDD:275368	6/19 (32%)
		zf-H2C2_2	536..561	CDD:290200	8/82 (10%)
		C2H2 Zn finger	552..573	CDD:275368	3/39 (8%)
		zf-C2H2	587..609	CDD:278523	9/22 (41%)
		C2H2 Zn finger	589..609	CDD:275368	8/20 (40%)
AT3G29340	NP_189580.1	zf-C2H2_6	43..68	CDD:290623	9/27 (33%)
		C2H2 Zn finger	45..65	CDD:275368	7/19 (37%)
		C2H2 Zn finger	100..120	CDD:275368	5/44 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100