DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CTCF and Zfp202

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_109638.2	Gene:	Zfp202 / 80902	MGIID:	1933401	Length:	641	Species:	Mus musculus

Alignment Length:	656	Identity:	145/656 - (22%)
Similarity:	237/656 - (36%)	Gaps:	177/656 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RTKKDEDPEDLQTFLNNFHKE-----------IEGNSDEKVVNTILEAISAEAIDLDENGAEAGG 57
            |.::.|..|:..|.:....|:           ::|.          |.:|.|.:.|   |.|...
Mouse   107 RGQRPESGEEAVTLVEGLQKQPRRPRRWVTVHVQGQ----------EVLSEETLHL---GLEPES 158

  Fly    58 S-------------KPMEEAEADLDHAEEAEEEEEDDEDKYFIDDEGNCYIKTTPKKQKELQKKL 109
            |             :|.|||....|...:.:|..:.||:...:.:   |.:..:    :::....
Mouse   159 SSEQQDPTQTLTTEQPHEEALRSPDLGTQEQETLQHDEEHLPLPE---CEVPVS----QDVDLPT 216

  Fly   110 KQAAAKPGKATRSVVSTATNKSINLRPAKSTPKATTSKPPPEPKAISVRPARAAAAKAKQSAMPP 174
            :|.:..|     .:|:..|..|..|                    ::.:......::.:.|.:.|
Mouse   217 EQGSGHP-----EMVALLTALSQGL--------------------VTFKDVALCFSQDQWSDLDP 256

  Fly   175 PP-------------ALVVKVPAPRGRPRKNPVIPKPEPMDLERELEELVDEPDISSMVTELSDY 226
            ..             .:||.:..|         ||:.:.....||     :||.:..
Mouse   257 TQKEFYGEYVLEEDCGIVVSLSFP---------IPRLDDTSQIRE-----EEPQVPG-------- 299

  Fly   227 TVDEAAVEAATATLTPNEAEVYEFE---DNATTEDENADKKDV-DFVLSNKEV------KLKTAS 281
             |.|:.        .|.|.|:..|.   |.:..|:|:.:::|. ...|:|.||      ::....
Mouse   300 -VHESQ--------EPAEPEILSFTYTGDMSEAEEESVEQQDTHKSTLANTEVHQSPDWEIVIED 355

  Fly   282 STSQNSNASGHKYSCPHCPYTASKKFLITRHS---RSHDVEPSFKCSICERSFRSNVGLQNHINT 343
            :||:.:...|...|..: .:|..::.:.. ||   |.|      .|.:|.:||..|..|..|:.|
Mouse   356 NTSRLNERFGTNVSKVN-SFTNIRETMPV-HSQSGRQH------HCPLCAKSFTCNSHLIRHLRT 412

  Fly   344 HMGNKPHKCKLCESAFTTSGELVRHTRYKHTKEKPHKCTECTYASVELTKLRRHMTCHTGERPYQ 408
            |.|.||:||..|..::|.|..|.||.:. |....|||... ...:|:...::..:|... |:||.
Mouse   413 HTGEKPYKCMECGKSYTRSSHLARHQKV-HKMNTPHKHPP-NRKTVDGPLVQSEVTTRV-EKPYT 474

  Fly   409 CPHCTYASQDMFKLKRHMVIHTGEKKYQCDICKSRFTQSNSLKAHKLIHSVVDKPVFQCNYCPTT 473
            |..|....:....|.||...|||||.:.|.||...|:|.:.|..|:.||
Mouse   475 CDDCGKHFRWTSDLVRHQRTHTGEKPFFCTICSKSFSQKSVLTTHQRIH---------------- 523

  Fly   474 CGRKADLRVHIKHMHTSDVPMTCRRCGQQLPDRYQYKLHVKSHEGEKCYSCKLCSYASVTQRHLA 538
            .|.|               |..|..||:...::.||..|.|:|..|:.:.|..|..:.......|
Mouse   524 VGGK---------------PYVCANCGENFSEQKQYLTHRKTHVSEEHHLCNECGRSFSHSAAFA 573

  Fly   539 SHMLIHLDEKPFHCDQCPQAFRQRQLLRRHMNLVHNEEYQPPEPREKLHKCPSCPREFTHKGNLM 603
            .|:..|...:...||:|.:.|.:|..|.||         |.....||...|.:|.:.|:...:|:
Mouse   574 KHLKGHASVRNCRCDECGKTFSRRDHLVRH---------QRTHTGEKPFTCATCGKSFSRGYHLI 629

  Fly   604 RHMETH 609
            ||...|
Mouse   630 RHQRVH 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226	12/102 (12%)
		C2H2 Zn finger	296..316	CDD:275368	4/22 (18%)
		COG5048	321..>621	CDD:227381	83/289 (29%)
		zf-C2H2	322..344	CDD:278523	7/21 (33%)
		C2H2 Zn finger	324..344	CDD:275368	7/19 (37%)
		zf-H2C2_2	337..361	CDD:290200	10/23 (43%)
		C2H2 Zn finger	352..373	CDD:275368	7/20 (35%)
		C2H2 Zn finger	381..401	CDD:275368	2/19 (11%)
		zf-H2C2_2	394..415	CDD:290200	6/20 (30%)
		C2H2 Zn finger	409..429	CDD:275368	5/19 (26%)
		zf-H2C2_2	422..446	CDD:290200	12/23 (52%)
		C2H2 Zn finger	437..457	CDD:275368	7/19 (37%)
		C2H2 Zn finger	467..485	CDD:275368	2/17 (12%)
		C2H2 Zn finger	496..516	CDD:275370	7/19 (37%)
		C2H2 Zn finger	524..544	CDD:275368	4/19 (21%)
		zf-H2C2_2	536..561	CDD:290200	7/24 (29%)
		C2H2 Zn finger	552..573	CDD:275368	8/20 (40%)
		zf-C2H2	587..609	CDD:278523	6/21 (29%)
		C2H2 Zn finger	589..609	CDD:275368	6/19 (32%)
Zfp202	NP_109638.2	SCAN	43..153	CDD:128708	10/58 (17%)
		KRAB	237..297	CDD:214630	11/73 (15%)
		COG5048	<332..624	CDD:227381	93/342 (27%)
		C2H2 Zn finger	393..413	CDD:275368	7/19 (37%)
		C2H2 Zn finger	421..441	CDD:275368	7/20 (35%)
		C2H2 Zn finger	475..495	CDD:275368	5/19 (26%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	7/19 (37%)
		C2H2 Zn finger	559..579	CDD:275368	4/19 (21%)
		C2H2 Zn finger	587..607	CDD:275368	9/28 (32%)
		C2H2 Zn finger	615..635	CDD:275368	6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000