DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CTCF and ZNF613

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_001026891.2	Gene:	ZNF613 / 79898	HGNCID:	25827	Length:	617	Species:	Homo sapiens

Alignment Length:	569	Identity:	146/569 - (25%)
Similarity:	227/569 - (39%)	Gaps:	106/569 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 EPMDLERELEELVDEPDISSMVTELSDYT--------VDEAAVEAATATLTPNEAEVYEFEDNAT 255
            ||..:|.|:...:. |:|..:...|..::        |::.....|...:.......:....|..
Human    64 EPWTVENEIHSQIC-PEIKKVDNHLQMHSQKQRCLKRVEQCHKHNAFGNIIHQRKSDFPLRQNHD 127

  Fly   256 TEDENAD--KKDVDFVLSNKEVKLKTA----------------------------SSTSQNSNAS 290
            |.|.:..  |.::..|..||..::|.:                            :|.:.||...
Human   128 TFDLHGKILKSNLSLVNQNKRYEIKNSVGVNGDGKSFLHAKHEQFHNEMNFPEGGNSVNTNSQFI 192

  Fly   291 GHK--------YSCPHCPYTASKKFLITRHSRSHDVEPSFKCSICERSFRSNVGLQNHINTHMGN 347
            .|:        :.|..|.....||..:..|.|.|..|....||||.::|....||..|...|.|.
Human   193 KHQRTQNIDKPHVCTECGKAFLKKSRLIYHQRVHTGEKPHGCSICGKAFSRKSGLTEHQRNHTGE 257

  Fly   348 KPHKCKLCESAF-----------TTSGE-----------------LVRHTRYKHTKEKPHKCTEC 384
            ||::|..|:.||           ..:||                 |:.|.|. ||.||||.|:.|
Human   258 KPYECTECDKAFRWKSQLNAHQKIHTGEKSYICSDCGKGFIKKSRLINHQRV-HTGEKPHGCSLC 321

  Fly   385 TYASVELTKLRRHMTCHTGERPYQCPHCTYASQDMFKLKRHMVIHTGEKKYQCDICKSRFTQSNS 449
            ..|..:.::|..|...||||:||:|..|..|.:...:|..|...|||||.|.|..|...|.|..:
Human   322 GKAFSKRSRLTEHQRTHTGEKPYECTECDKAFRWKSQLNAHQKAHTGEKSYICRDCGKGFIQKGN 386

  Fly   450 LKAHKLIHSVVDKPVFQCNYCPTTCGRKADLRVHIKHMHTSDVPMTCRRCGQQLPDRYQYKLHVK 514
            |..|:.||: .:|| :.||.|.....:|.:|.:| :..||.:.|..|..||:....:.....|.:
Human   387 LIVHQRIHT-GEKP-YICNECGKGFIQKGNLLIH-RRTHTGEKPYVCNECGKGFSQKTCLISHQR 448

  Fly   515 SHEGEKCYSCKLCSYASVTQRHLASHMLIHLDEKPFHCDQCPQAFRQRQLLRRHMNLVHNEEYQP 579
            .|.|:..:.|..|..:...:..|.:|..||..|||:.|..|.:|||.:..|.||.. .|.
Human   449 FHTGKTPFVCTECGKSCSHKSGLINHQRIHTGEKPYTCSDCGKAFRDKSCLNRHRR-THT----- 507

  Fly   580 PEPREKLHKCPSCPREFTHKGNLMRHMETHDDSANAREKRRRLKLGRNVRLQKDGTVITLIKDQY 644
               .|:.:.|..|.:.|:|...|:    .|....:||||    .:| :|:|:...:     :...
Human   508 ---GERPYGCSDCGKAFSHLSCLV----YHKGMLHAREK----CVG-SVKLENPCS-----ESHS 555

  Fly   645 VDMDRDQEENEEDDNPESYDLAEIEPENS---EAEDADDDVETIVSDPI 690
            :...||..::::..|..:..:..:..:.|   .|..|:..| .|||.|:
Human   556 LSHTRDLIQDKDSVNMVTLQMPSVAAQTSLTNSAFQAESKV-AIVSQPV 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226	3/6 (50%)
		C2H2 Zn finger	296..316	CDD:275368	6/19 (32%)
		COG5048	321..>621	CDD:227381	103/327 (31%)
		zf-C2H2	322..344	CDD:278523	8/21 (38%)
		C2H2 Zn finger	324..344	CDD:275368	8/19 (42%)
		zf-H2C2_2	337..361	CDD:290200	10/34 (29%)
		C2H2 Zn finger	352..373	CDD:275368	9/48 (19%)
		C2H2 Zn finger	381..401	CDD:275368	5/19 (26%)
		zf-H2C2_2	394..415	CDD:290200	10/20 (50%)
		C2H2 Zn finger	409..429	CDD:275368	5/19 (26%)
		zf-H2C2_2	422..446	CDD:290200	11/23 (48%)
		C2H2 Zn finger	437..457	CDD:275368	6/19 (32%)
		C2H2 Zn finger	467..485	CDD:275368	6/17 (35%)
		C2H2 Zn finger	496..516	CDD:275370	4/19 (21%)
		C2H2 Zn finger	524..544	CDD:275368	4/19 (21%)
		zf-H2C2_2	536..561	CDD:290200	11/24 (46%)
		C2H2 Zn finger	552..573	CDD:275368	8/20 (40%)
		zf-C2H2	587..609	CDD:278523	5/21 (24%)
		C2H2 Zn finger	589..609	CDD:275368	5/19 (26%)
ZNF613	NP_001026891.2	KRAB	8..67	CDD:214630	2/2 (100%)
		KRAB	8..47	CDD:279668
		COG5048	176..531	CDD:227381	110/371 (30%)
		C2H2 Zn finger	206..226	CDD:275368	6/19 (32%)
		C2H2 Zn finger	234..254	CDD:275368	8/19 (42%)
		zf-H2C2_2	247..269	CDD:290200	8/21 (38%)
		C2H2 Zn finger	262..282	CDD:275368	4/19 (21%)
		C2H2 Zn finger	290..310	CDD:275368	3/20 (15%)
		C2H2 Zn finger	318..338	CDD:275368	5/19 (26%)
		zf-H2C2_2	331..353	CDD:290200	10/21 (48%)
		C2H2 Zn finger	346..366	CDD:275368	5/19 (26%)
		C2H2 Zn finger	374..394	CDD:275368	6/19 (32%)
		zf-H2C2_2	386..411	CDD:290200	9/26 (35%)
		C2H2 Zn finger	402..422	CDD:275368	6/20 (30%)
		zf-H2C2_2	414..439	CDD:290200	8/25 (32%)
		C2H2 Zn finger	430..450	CDD:275368	4/19 (21%)
		C2H2 Zn finger	458..478	CDD:275368	4/19 (21%)
		zf-H2C2_2	471..493	CDD:290200	9/21 (43%)
		zf-C2H2	484..506	CDD:278523	8/22 (36%)
		C2H2 Zn finger	486..506	CDD:275368	8/20 (40%)
		zf-H2C2_2	499..523	CDD:290200	8/32 (25%)
		C2H2 Zn finger	514..530	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910