Protein Alignment CTCF and ZNF212

DIOPT Version :10

• Sequence 1: NP_648109.1
• Gene: CTCF / 38817
• FlyBaseID: FBgn0035769
• Length: 818
• Species: Drosophila melanogaster
• Sequence 2: NP_036388.2
• Gene: ZNF212 / 7988
• HGNCID: 13004
• Length: 495
• Species: Homo sapiens
• Alignment Length: 306
• Identity: 62/306 - (20%)
• Similarity: 101/306 - (33%)
• Gaps: 95/306 - (31%)

  Fly   203 LERELEELVDEPDISSMVTELSDYTVDEAAVEAATATLTPNEAEVYEFEDNATTEDENADKKDVD 267
            :::||:...:.|         :|...:.:.:....|.|:|.:.|::..:.::
Human   216 IKQELQYTQEGP---------ADLPGEFSCIAEEQAFLSPEQTELWGGQGSS------------- 258

  Fly   268 FVLSNKEVKLKTASSTS-------QNSNASGHKYSCPHCPYTASKKFLITRHSRSH--------- 316
                   |.|:|....|       ....:|.....||              ..:||
Human   259 -------VLLETGPGDSTLEEPVGSRVPSSSRTVGCP--------------KQKSHRQVQLDQEC 302

  Fly   317 --------DVEPSFKCSICERSFRSNVGLQNHINTHMG-------------------------NK 348
                    |....::||.||.:||....|..|:.:|.|                         .|
Human   303 GQGLKLKKDTSRPYECSECEITFRYKQQLATHLRSHSGWGSCTPEEPEESLRPRPRLKPQTKKAK 367

  Fly   349 PHKCKLCESAFTTSGELVRHTRYKHTKEKPH--KCTECTYASVELTKLRRHMTCHTGERPYQCPH 411
            .|:|.:|..:|:....||.|.|. |.:|.|.  :..:..::...|..|..|:..........|.:
Human   368 LHQCDVCLRSFSCKVSLVTHQRC-HLQEGPSAGQHVQERFSPNSLVALPGHIPWRKSRSSLICGY 431

  Fly   412 CTYASQDMFKLKRHMVIHTGEKKYQCDICKSRFTQSNSLKAHKLIH 457
            |..:......|.||..|||||:.|.|..|:..|.|...|..|:.||
Human   432 CGKSFSHPSDLVRHQRIHTGERPYSCTECEKSFVQKQHLLQHQKIH 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	FAP	116..>202	CDD:429334
		C2H2 Zn finger	296..316	CDD:275368	2/19 (11%)
		COG5048	321..>621	CDD:227381	44/164 (27%)
		C2H2 Zn finger	324..344	CDD:275368	8/19 (42%)
		C2H2 Zn finger	352..373	CDD:275368	7/20 (35%)
		C2H2 Zn finger	381..401	CDD:275368	3/19 (16%)
		zf-H2C2_2	394..415	CDD:463886	4/20 (20%)
		C2H2 Zn finger	409..429	CDD:275368	5/19 (26%)
		zf-H2C2_2	422..446	CDD:463886	12/23 (52%)
		C2H2 Zn finger	437..457	CDD:275368	6/19 (32%)
		C2H2 Zn finger	467..485	CDD:275368
		C2H2 Zn finger	496..516	CDD:275370
		C2H2 Zn finger	524..544	CDD:275368
		zf-H2C2_2	536..561	CDD:463886
		C2H2 Zn finger	552..573	CDD:275368
		zf-C2H2	587..609	CDD:395048
		C2H2 Zn finger	589..609	CDD:275368
ZNF212	NP_036388.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29
		KRAB_A-box	142..180	CDD:143639
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	264..290		4/39 (10%)
		zf-C2H2	316..338	CDD:395048	8/21 (38%)
		C2H2 Zn finger	318..338	CDD:275370	8/19 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	337..361		2/23 (9%)
		C2H2 Zn finger	371..391	CDD:275368	7/20 (35%)
		C2H2 Zn finger	429..449	CDD:275368	5/19 (26%)
		zf-C2H2	429..449	CDD:395048	5/19 (26%)
		zf-C2H2	455..477	CDD:395048	7/21 (33%)
		C2H2 Zn finger	457..477	CDD:275368	6/19 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	476..495		2/2 (100%)