Protein Alignment CTCF and znf438

DIOPT Version :10

• Sequence 1: NP_648109.1
• Gene: CTCF / 38817
• FlyBaseID: FBgn0035769
• Length: 818
• Species: Drosophila melanogaster
• Sequence 2: NP_001070629.1
• Gene: znf438 / 798757
• ZFINID: ZDB-GENE-060929-868
• Length: 746
• Species: Danio rerio
• Alignment Length: 579
• Identity: 116/579 - (20%)
• Similarity: 199/579 - (34%)
• Gaps: 176/579 - (30%)

  Fly    86 FIDDEGNCYIKTTPKKQKELQKKLKQAAAKPGKATRSVVSTATNKSINLRPAKSTPKATTSKPPP 150
            |.|.:...:.|::||...|.:.|......|....::.:.:|...|....:|.:.      .|...
Zfish   273 FSDKQTVSWAKSSPKNPTENKVKFINNKVKTESLSQDLNNTQFKKPSGKKPGRK------RKTMG 331

  Fly   151 EPKAISVRPARAAAAKAKQSAMPPPPALVVKVPAPRGR-----PRKNPVIPKPEPMDLERELEEL 210
            :..|...|..|:.:...::....|||.  |:..|.:.:     .:...:.||| .:.:|..:.:|
Zfish   332 DILAFEARKKRSLSFFRRRVPEKPPPG--VQNSASQQKFLDISKKYRSIRPKP-VLVMEATIPQL 393

  Fly   211 VDEPDISSMVTELSDYTVDEAAVEAATATLTPNEAEVYEFEDNATTEDENADKKDVDFVLSNKEV 275
            |..|.:|:                                          :|..|.| :|:.:::
Zfish   394 VPLPSMSA------------------------------------------SDNPDQD-LLAGQQI 415

  Fly   276 KLKTASSTSQNSNASGHKYSCP--HCP------YTASKKFLITRHSRSHDVEPSFKCSICERSFR 332
            ..||.|: .|:|.|:..:   |  :|.      ||:|:  |:.|            |..|.|.|:
Zfish   416 SGKTLSA-PQSSQATDRQ---PVLNCKVNSGVIYTSSR--LLHR------------CPTCNRCFQ 462

  Fly   333 SNVGLQNHINTHMGNKPHKCKLCESAFTTSGELVRHTRYKHTKEKPHK---CTECT----YASVE 390
            ....||:|:|:|...:|:.|.:|..|:..||.|..|.:..|.:.||.|   |..|.    |..|.
Zfish   463 FKHHLQSHMNSHSNLRPYVCPVCRKAYAHSGSLSTHMKLHHAESKPRKSLCCEFCEKSFGYVGVY 527

  Fly   391 LTKLRRHMTCHTGERPYQCPHCTYASQDMFKLKRHMVIHTGEKKYQCDICKSRFTQSNSLKAHKL 455
            .:.||                           :.|.||.|.|...      |:..:|.|::....
Zfish   528 FSHLR---------------------------EVHRVILTVEPSI------SQHEESISVEESSE 559

  Fly   456 IHSVVDK----PV---FQCNYCPTTCGRKADLRVHIKHMHTSDVPMTCRRCGQQLPDRYQYKLHV 513
            |.....:    ||   .:|..|.......||:::|:.::|..:|               |.:|..
Zfish   560 IDEQASEQRVDPVELQIKCGRCQAITPTFADMKLHLLYVHGEEV---------------QVRLRD 609

  Fly   514 KSHEGEKCYSCKLCSYASVTQRHLASHMLIHLDEKP--FHCDQCPQAFRQRQLLRRHMNLVH--- 573
            .:..|.:....:|..:        |:|....|:||.  .||..|.:.|......:.|::..|
Zfish   610 GAMHGGREAEDELVKH--------AAHYWRQLNEKRNLVHCGTCNEEFFSFSKFKHHLHSNHQES 666

  Fly   574 -NEEYQPPEPREKL-----------------HKCPSCPREFTHKGNLMRHMETHDDSAN 614
             .||.:..|..||:                 ..|..|.:.|..|..::.|.....:..|
Zfish   667 PEEEEEEEEKEEKMVIGKGLSKDISLRVGSHFNCILCSKVFNKKQEVIEHWSAQHNCEN 725

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	FAP	116..>202	CDD:429334	15/90 (17%)
		C2H2 Zn finger	296..316	CDD:275368	7/27 (26%)
		COG5048	321..>621	CDD:227381	71/331 (21%)
		C2H2 Zn finger	324..344	CDD:275368	8/19 (42%)
		C2H2 Zn finger	352..373	CDD:275368	7/20 (35%)
		C2H2 Zn finger	381..401	CDD:275368	6/23 (26%)
		zf-H2C2_2	394..415	CDD:463886	2/20 (10%)
		C2H2 Zn finger	409..429	CDD:275368	2/19 (11%)
		zf-H2C2_2	422..446	CDD:463886	6/23 (26%)
		C2H2 Zn finger	437..457	CDD:275368	3/19 (16%)
		C2H2 Zn finger	467..485	CDD:275368	5/17 (29%)
		C2H2 Zn finger	496..516	CDD:275370	2/19 (11%)
		C2H2 Zn finger	524..544	CDD:275368	3/19 (16%)
		zf-H2C2_2	536..561	CDD:463886	9/26 (35%)
		C2H2 Zn finger	552..573	CDD:275368	4/20 (20%)
		zf-C2H2	587..609	CDD:395048	5/21 (24%)
		C2H2 Zn finger	589..609	CDD:275368	5/19 (26%)
znf438	NP_001070629.1	Herpes_BLLF1	<113..>292	CDD:282904	5/18 (28%)
		zf-C2H2	452..474	CDD:395048	9/33 (27%)
		C2H2 Zn finger	454..474	CDD:275368	8/19 (42%)
		zf-H2C2_2	466..491	CDD:463886	9/24 (38%)
		C2H2 Zn finger	482..502	CDD:275368	7/19 (37%)
		C2H2 Zn finger	514..532	CDD:275368	4/17 (24%)