Protein Alignment CTCF and ZNF665

DIOPT Version :10

• Sequence 1: NP_648109.1
• Gene: CTCF / 38817
• FlyBaseID: FBgn0035769
• Length: 818
• Species: Drosophila melanogaster
• Sequence 2: NP_001340387.1
• Gene: ZNF665 / 79788
• HGNCID: 25885
• Length: 706
• Species: Homo sapiens
• Alignment Length: 424
• Identity: 133/424 - (31%)
• Similarity: 178/424 - (41%)
• Gaps: 73/424 - (17%)

  Fly   243 NEAEVYEFEDNATTEDENADKKDVDFVLSNKEVKLKTASST-SQNSNASGHK------------- 293
            :|.::||:  |...:..|.         ..|..|....... ||||..:.||
Human   185 HEGKIYEY--NQVEKSPNN---------RGKHYKCDECGKVFSQNSRLTSHKRIHTGEKPYQCNK 238

  Fly   294 -----------------------YSCPHCPYTASKKFLITRHSRSHDVEPSFKCSICERSFRSNV 335
                                   |.|..|....|:...:..|.|.|..|..:||:.|.::||::.
Human   239 CGKAFTVRSNLTIHQVIHTGEKPYKCNECGKVFSQPSNLAGHQRIHTGEKPYKCNECGKAFRAHS 303

  Fly   336 GLQNHINTHMGNKPHKCKLCESAFTTSGELVRHTRYKHTKEKPHKCTECTYASVELTKLRRHMTC 400
            .|..|...|.|.||:|||.|...||.:..|..|.|. ||.|||:||.||..|....:.|..|.|.
Human   304 KLTTHQVIHTGEKPYKCKECGKCFTQNSHLASHRRI-HTGEKPYKCNECGKAFSVRSSLTTHQTI 367

  Fly   401 HTGERPYQCPHCTYASQDMFKLKRHMVIHTGEKKYQCDICKSRFTQSNSLKAHKLIHSVVDKPVF 465
            ||||:||:|..|....:....|.:|..||||||.|:|:.|...|:..::|..|::||: .:|| |
Human   368 HTGEKPYKCNECGKVFRHNSYLAKHRRIHTGEKPYKCNECGKAFSMHSNLTKHQIIHT-GEKP-F 430

  Fly   466 QCNYCPTTCGRKADLRVHIKHMHTSDVPMTCRRCGQQLPDRYQYKLHVKSHEGEKCYSCKLCSYA 530
            :||.|.....:.:.|..| :.:||.:.|..|..||:....|.....|...|.|||.|.|..|...
Human   431 KCNECVKVFTQYSHLANH-RRIHTGEKPYRCDECGKAFSVRSSLTTHQAIHTGEKPYKCNDCGKV 494

  Fly   531 SVTQRHLASHMLIHLDEKPFHCDQCPQAFRQRQLLRRHMNLVHNEE------------------- 576
            .....|||||..||..|||:.||:|.:||.|...|.||.. ||..|
Human   495 FTQNSHLASHRGIHSGEKPYKCDECGKAFSQTSQLARHWR-VHTGEKPYKCNECGKAFSVHSSLT 558

  Fly   577 -YQPPEPREKLHKCPSCPREFTHKGNLMRHMETH 609
             :|.....:|.:||..|.:.|.|...|..|...|
Human   559 IHQTIHTGQKPYKCNDCGKVFRHNSYLAIHQRIH 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	FAP	116..>202	CDD:429334
		C2H2 Zn finger	296..316	CDD:275368	5/19 (26%)
		COG5048	321..>621	CDD:227381	112/309 (36%)
		C2H2 Zn finger	324..344	CDD:275368	6/19 (32%)
		C2H2 Zn finger	352..373	CDD:275368	8/20 (40%)
		C2H2 Zn finger	381..401	CDD:275368	7/19 (37%)
		zf-H2C2_2	394..415	CDD:463886	11/20 (55%)
		C2H2 Zn finger	409..429	CDD:275368	4/19 (21%)
		zf-H2C2_2	422..446	CDD:463886	12/23 (52%)
		C2H2 Zn finger	437..457	CDD:275368	5/19 (26%)
		C2H2 Zn finger	467..485	CDD:275368	5/17 (29%)
		C2H2 Zn finger	496..516	CDD:275370	5/19 (26%)
		C2H2 Zn finger	524..544	CDD:275368	7/19 (37%)
		zf-H2C2_2	536..561	CDD:463886	15/24 (63%)
		C2H2 Zn finger	552..573	CDD:275368	9/20 (45%)
		zf-C2H2	587..609	CDD:395048	7/21 (33%)
		C2H2 Zn finger	589..609	CDD:275368	6/19 (32%)
ZNF665	NP_001340387.1	KRAB	37..76	CDD:460171
		COG5048	192..580	CDD:227381	125/403 (31%)
		C2H2 Zn finger	208..228	CDD:275368	6/19 (32%)
		C2H2 Zn finger	236..256	CDD:275368	0/19 (0%)
		C2H2 Zn finger	264..284	CDD:275368	5/19 (26%)
		C2H2 Zn finger	292..312	CDD:275368	6/19 (32%)
		C2H2 Zn finger	320..340	CDD:275368	8/20 (40%)
		C2H2 Zn finger	348..368	CDD:275368	7/19 (37%)
		C2H2 Zn finger	376..396	CDD:275368	4/19 (21%)
		C2H2 Zn finger	404..424	CDD:275368	5/19 (26%)
		C2H2 Zn finger	432..452	CDD:275368	5/20 (25%)
		C2H2 Zn finger	460..480	CDD:275368	5/19 (26%)
		C2H2 Zn finger	488..508	CDD:275368	7/19 (37%)
		C2H2 Zn finger	516..536	CDD:275368	9/20 (45%)
		C2H2 Zn finger	544..564	CDD:275368	1/19 (5%)
		C2H2 Zn finger	572..592	CDD:275368	6/19 (32%)
		zf-H2C2_2	584..608	CDD:463886	3/9 (33%)
		C2H2 Zn finger	600..620	CDD:275368
		zf-H2C2_2	612..637	CDD:463886
		C2H2 Zn finger	628..648	CDD:275368
		zf-H2C2_2	640..664	CDD:463886
		C2H2 Zn finger	656..676	CDD:275368
		zf-H2C2_2	669..693	CDD:463886
		C2H2 Zn finger	684..704	CDD:275368