Protein Alignment CTCF and ZNF184

DIOPT Version :10

• Sequence 1: NP_648109.1
• Gene: CTCF / 38817
• FlyBaseID: FBgn0035769
• Length: 818
• Species: Drosophila melanogaster
• Sequence 2: NP_009080.2
• Gene: ZNF184 / 7738
• HGNCID: 12975
• Length: 751
• Species: Homo sapiens
• Alignment Length: 459
• Identity: 144/459 - (31%)
• Similarity: 199/459 - (43%)
• Gaps: 67/459 - (14%)

  Fly   193 PVIPKPEPMDLERELEELVD--EPDISSMVTELSDYTVDEAAVEAATATLTPNEAEVYEFEDNAT 255
            |.||.....|.|..||..|.  |||||.  .|||...:.|.  .....:.:.|..|.:|:|.:..
Human    91 PSIPVGTCADWETRLENSVSAPEPDISE--EELSPEVIVEK--HKRDDSWSSNLLESWEYEGSLE 151

  Fly   256 TEDENADKKDVDFVLSNKEV------------------------------KLKTASSTSQNSNAS 290
            .:..|......:..::.|.:                              :..|..|..||||..
Human   152 RQQANQQTLPKEIKVTEKTIPSWEKGPVNNEFGKSVNVSSNLVTQEPSPEETSTKRSIKQNSNPV 216

  Fly   291 GHKYSCP--HCPYTASKKFLITRHSRSHDVEPSFKCSICERSFRSNVGLQNHINTHMGNKPHKCK 353
            ..:.||.  .|....|....:.||.|:|..|..:||:.||::|..:..|.||...|.|:||:||.
Human   217 KKEKSCKCNECGKAFSYCSALIRHQRTHTGEKPYKCNECEKAFSRSENLINHQRIHTGDKPYKCD 281

  Fly   354 LCESAFTTSGELVRHTRYKHTKEKPHKCTECTYASVELTKLRRHMTCHTGERPYQCPHCTYASQD 418
            .|...|.....|.:|.|. ||.|||:||.||..|..:.|.|.:|...||||:||.|..|..|...
Human   282 QCGKGFIEGPSLTQHQRI-HTGEKPYKCDECGKAFSQRTHLVQHQRIHTGEKPYTCNECGKAFSQ 345

  Fly   419 MFKLKRHMVIHTGEKKYQCDICKSRFTQSNSLKAHKLIHSVVDKPVFQCNYC------PTTCGRK 477
            ......|..||||||.::||.|...||:|..|..|:.||:  .:..::||.|      |:|
Human   346 RGHFMEHQKIHTGEKPFKCDECDKTFTRSTHLTQHQKIHT--GEKTYKCNECGKAFNGPST---- 404

  Fly   478 ADLRVHIKH--MHTSDVPMTCRRCGQQLPDRYQYKLHVKSHEGEKCYSCKLCSYASVTQRHLASH 540
                 .|:|  :||.:.|..|..||:..........|.|:|.|||.|.|..|..:......||.|
Human   405 -----FIRHHMIHTGEKPYECNECGKAFSQHSNLTQHQKTHTGEKPYDCAECGKSFSYWSSLAQH 464

  Fly   541 MLIHLDEKPFHCDQCPQAFRQRQLLRRHMNLVHNEEYQPPEPREKLHKCPSCPREFTHKGNLMRH 605
            :.||..|||:.|::|.:||.....|.:|.. :|.        |||..:|..|.:.|::..||.:|
Human   465 LKIHTGEKPYKCNECGKAFSYCSSLTQHRR-IHT--------REKPFECSECGKAFSYLSNLNQH 520

  Fly   606 METH 609
            .:||
Human   521 QKTH 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	FAP	116..>202	CDD:429334	3/8 (38%)
		C2H2 Zn finger	296..316	CDD:275368	6/21 (29%)
		COG5048	321..>621	CDD:227381	106/297 (36%)
		C2H2 Zn finger	324..344	CDD:275368	7/19 (37%)
		C2H2 Zn finger	352..373	CDD:275368	6/20 (30%)
		C2H2 Zn finger	381..401	CDD:275368	7/19 (37%)
		zf-H2C2_2	394..415	CDD:463886	10/20 (50%)
		C2H2 Zn finger	409..429	CDD:275368	4/19 (21%)
		zf-H2C2_2	422..446	CDD:463886	11/23 (48%)
		C2H2 Zn finger	437..457	CDD:275368	8/19 (42%)
		C2H2 Zn finger	467..485	CDD:275368	5/23 (22%)
		C2H2 Zn finger	496..516	CDD:275370	5/19 (26%)
		C2H2 Zn finger	524..544	CDD:275368	5/19 (26%)
		zf-H2C2_2	536..561	CDD:463886	12/24 (50%)
		C2H2 Zn finger	552..573	CDD:275368	6/20 (30%)
		zf-C2H2	587..609	CDD:395048	6/21 (29%)
		C2H2 Zn finger	589..609	CDD:275368	6/19 (32%)
ZNF184	NP_009080.2	KRAB	28..88	CDD:214630
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	191..212		2/20 (10%)
		C2H2 Zn finger	224..244	CDD:275368	5/19 (26%)
		COG5048	<248..409	CDD:227381	64/172 (37%)
		C2H2 Zn finger	252..272	CDD:275368	7/19 (37%)
		C2H2 Zn finger	280..300	CDD:275368	6/20 (30%)
		C2H2 Zn finger	308..328	CDD:275368	7/19 (37%)
		C2H2 Zn finger	336..356	CDD:275368	4/19 (21%)
		COG5048	360..736	CDD:227381	59/185 (32%)
		C2H2 Zn finger	364..384	CDD:275368	8/19 (42%)
		C2H2 Zn finger	392..412	CDD:275368	7/28 (25%)
		C2H2 Zn finger	420..440	CDD:275368	5/19 (26%)
		C2H2 Zn finger	448..468	CDD:275368	5/19 (26%)
		C2H2 Zn finger	476..496	CDD:275368	6/20 (30%)
		C2H2 Zn finger	504..524	CDD:275368	6/19 (32%)
		C2H2 Zn finger	532..552	CDD:275368
		C2H2 Zn finger	560..580	CDD:275368
		C2H2 Zn finger	588..608	CDD:275368
		C2H2 Zn finger	616..636	CDD:275368
		C2H2 Zn finger	644..664	CDD:275368
		C2H2 Zn finger	672..692	CDD:275368
		C2H2 Zn finger	700..720	CDD:275368
		C2H2 Zn finger	728..748	CDD:275368