DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CTCF and ZNF132

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_003424.3	Gene:	ZNF132 / 7691	HGNCID:	12916	Length:	706	Species:	Homo sapiens

Alignment Length:	343	Identity:	115/343 - (33%)
Similarity:	170/343 - (49%)	Gaps:	25/343 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   277 LKTASSTSQNSNASGHK--------YSCPHCPYTASKKFLITRHSRSHDVEPSFKCSICERSFRS 333
            ||...:.||:||...|:        |.|..|..:.|:...:.:|.|.|..|..::||.|.|:|.:
Human   378 LKCGRAFSQSSNFLRHQKVHTQVRPYECSQCGKSFSRSSALIQHWRVHTGERPYECSECGRAFNN 442

  Fly   334 NVGLQNHINTHMGNKPHKCKLCESAFTTSGELVRHTRYKHTKEKPHKCTECTYASVELTKLRRHM 398
            |..|..|...|.|.:|.:|..|...|:.|..|:||.:. ||.|:|.:|.:|..|....:.|.:|.
Human   443 NSNLAQHQKVHTGERPFECSECGRDFSQSSHLLRHQKV-HTGERPFECCDCGKAFSNSSTLIQHQ 506

  Fly   399 TCHTGERPYQCPHCTYASQDMFKLKRHMVIHTGEKKYQCDICKSRFTQSNSLKAHKLIHSVVDKP 463
            ..|||:|||:|..|..:......|.:|..||||||.|:|..|...|..|::|..|..:|: .::|
Human   507 KVHTGQRPYECSECRKSFSRSSSLIQHWRIHTGEKPYECSECGKAFAHSSTLIEHWRVHT-KERP 570

  Fly   464 VFQCNYCPTTCGRKADLRVHIKH--MHTSDVPMTCRRCGQQLPDRYQYKLHVKSHEGEKCYSCKL 526
             ::||.|.....:.:.|   |||  :||.:.|..|..||:....:.....|.:.|.||:.|.|..
Human   571 -YECNECGKFFSQNSIL---IKHQKVHTGEKPYKCSECGKFFSRKSSLICHWRVHTGERPYECSE 631

  Fly   527 CSYASVTQRHLASHMLIHLDEKPFHCDQCPQAFRQRQLLRRHMNLVHNEEYQPPEPREKLHKCPS 591
            |..|..:..||..|..:|..|:|:.|.||.:||.:|..|.||.. ||.        ||:.::|..
Human   632 CGRAFSSNSHLVRHQRVHTQERPYECIQCGKAFSERSTLVRHQK-VHT--------RERTYECSQ 687

  Fly   592 CPREFTHKGNLMRHMETH 609
            |.:.|:|..||.:|.:.|
Human   688 CGKLFSHLCNLAQHKKIH 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226
		C2H2 Zn finger	296..316	CDD:275368	5/19 (26%)
		COG5048	321..>621	CDD:227381	100/291 (34%)
		zf-C2H2	322..344	CDD:278523	8/21 (38%)
		C2H2 Zn finger	324..344	CDD:275368	8/19 (42%)
		zf-H2C2_2	337..361	CDD:290200	8/23 (35%)
		C2H2 Zn finger	352..373	CDD:275368	7/20 (35%)
		C2H2 Zn finger	381..401	CDD:275368	5/19 (26%)
		zf-H2C2_2	394..415	CDD:290200	10/20 (50%)
		C2H2 Zn finger	409..429	CDD:275368	4/19 (21%)
		zf-H2C2_2	422..446	CDD:290200	12/23 (52%)
		C2H2 Zn finger	437..457	CDD:275368	6/19 (32%)
		C2H2 Zn finger	467..485	CDD:275368	4/17 (24%)
		C2H2 Zn finger	496..516	CDD:275370	4/19 (21%)
		C2H2 Zn finger	524..544	CDD:275368	6/19 (32%)
		zf-H2C2_2	536..561	CDD:290200	11/24 (46%)
		C2H2 Zn finger	552..573	CDD:275368	9/20 (45%)
		zf-C2H2	587..609	CDD:278523	7/21 (33%)
		C2H2 Zn finger	589..609	CDD:275368	7/19 (37%)
ZNF132	NP_003424.3	KRAB	37..78	CDD:307490
		COG5048	105..528	CDD:227381	50/150 (33%)
		C2H2 Zn finger	116..136	CDD:275368
		C2H2 Zn finger	144..164	CDD:275368
		C2H2 Zn finger	238..285	CDD:275368
		C2H2 Zn finger	293..313	CDD:275368
		C2H2 Zn finger	321..341	CDD:275368
		C2H2 Zn finger	349..369	CDD:275368
		C2H2 Zn finger	377..397	CDD:275368	7/18 (39%)
		COG5048	383..>706	CDD:227381	113/338 (33%)
		C2H2 Zn finger	405..425	CDD:275368	5/19 (26%)
		C2H2 Zn finger	433..453	CDD:275368	8/19 (42%)
		C2H2 Zn finger	461..481	CDD:275368	7/20 (35%)
		C2H2 Zn finger	489..509	CDD:275368	5/19 (26%)
		C2H2 Zn finger	517..537	CDD:275368	4/19 (21%)
		C2H2 Zn finger	545..565	CDD:275368	6/19 (32%)
		C2H2 Zn finger	573..593	CDD:275368	7/22 (32%)
		C2H2 Zn finger	601..621	CDD:275368	4/19 (21%)
		C2H2 Zn finger	629..649	CDD:275368	6/19 (32%)
		C2H2 Zn finger	657..677	CDD:275368	9/20 (45%)
		C2H2 Zn finger	685..705	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000