Protein Alignment CTCF and ZNF91

DIOPT Version :10

• Sequence 1: NP_648109.1
• Gene: CTCF / 38817
• FlyBaseID: FBgn0035769
• Length: 818
• Species: Drosophila melanogaster
• Sequence 2: NP_003421.2
• Gene: ZNF91 / 7644
• HGNCID: 13166
• Length: 1191
• Species: Homo sapiens
• Alignment Length: 407
• Identity: 132/407 - (32%)
• Similarity: 185/407 - (45%)
• Gaps: 66/407 - (16%)

  Fly   237 TATLTPNEAEVYEFEDNATTEDENADKKDVDFVLSNKEVKLKTASST-SQNSNASGHK------- 293
            ::||| |..|::       |||              |..|.:..... .|.|..:.||
Human   222 SSTLT-NHKEIH-------TED--------------KPYKCEECGKAFKQLSTLTTHKIICAKEK 264

  Fly   294 -YSCPHCPYTASKKFL----ITRHSRSHDVEPSFKCSICERSFRSNVGLQNHINTHMGNKPHKCK 353
             |.|..|    .|.||    :|||.|.|..|..:||..|.::|..:..|..|...|.|.||:||:
Human   265 IYKCEEC----GKAFLWSSTLTRHKRIHTGEKPYKCEECGKAFSHSSTLAKHKRIHTGEKPYKCE 325

  Fly   354 LCESAFTTSGELVRHTRYKHTKEKPHKCTECTYASVELTKLRRHMTCHTGERPYQCPHCTYASQD 418
            .|..||:.|..|.:|.|. ||.|||:||.||..|....:.|..|...||.|:||:|..|..|.:.
Human   326 ECGKAFSRSSTLAKHKRI-HTGEKPYKCKECGKAFSNSSTLANHKITHTEEKPYKCKECDKAFKR 389

  Fly   419 MFKLKRHMVIHTGEKKYQCDICKSRFTQSNSLKAHKLIHSVVDKPVFQCNYCPTTCGRKADLRVH 483
            :..|.:|.:||.|||.|:|:.|...|.:|::|..||.||: .:|| ::|..|.......:.|..|
Human   390 LSTLTKHKIIHAGEKLYKCEECGKAFNRSSNLTIHKFIHT-GEKP-YKCEECGKAFNWSSSLTKH 452

  Fly   484 IKHMHTSDVPMTCRRCGQQLPDRYQYKLHVKSHEGEKCYSCKLCSYASVTQRHLASHMLIHLDEK 548
             |..||.:.|..|:.||:..........|.:.|.|||.|.|:.|..|......|..|.:||..||
Human   453 -KRFHTREKPFKCKECGKAFIWSSTLTRHKRIHTGEKPYKCEECGKAFRQSSTLTKHKIIHTGEK 516

  Fly   549 PFHCDQCPQAFRQRQLLRRHMNLVHNEEYQPPEPRE---------------------KLHKCPSC 592
            |:..::|.:||||...|.:| .::|:.| :|.:.:|                     ||:||..|
Human   517 PYKFEECGKAFRQSLTLNKH-KIIHSRE-KPYKCKECGKAFKQFSTLTTHKIIHAGKKLYKCEEC 579

  Fly   593 PREFTHKGNLMRHMETH 609
            .:.|.|..:|..|...|
Human   580 GKAFNHSSSLSTHKIIH 596

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	FAP	116..>202	CDD:429334
		C2H2 Zn finger	296..316	CDD:275368	9/23 (39%)
		COG5048	321..>621	CDD:227381	106/310 (34%)
		C2H2 Zn finger	324..344	CDD:275368	5/19 (26%)
		C2H2 Zn finger	352..373	CDD:275368	8/20 (40%)
		C2H2 Zn finger	381..401	CDD:275368	6/19 (32%)
		zf-H2C2_2	394..415	CDD:463886	9/20 (45%)
		C2H2 Zn finger	409..429	CDD:275368	5/19 (26%)
		zf-H2C2_2	422..446	CDD:463886	11/23 (48%)
		C2H2 Zn finger	437..457	CDD:275368	7/19 (37%)
		C2H2 Zn finger	467..485	CDD:275368	4/17 (24%)
		C2H2 Zn finger	496..516	CDD:275370	4/19 (21%)
		C2H2 Zn finger	524..544	CDD:275368	5/19 (26%)
		zf-H2C2_2	536..561	CDD:463886	10/24 (42%)
		C2H2 Zn finger	552..573	CDD:275368	7/20 (35%)
		zf-C2H2	587..609	CDD:395048	7/21 (33%)
		C2H2 Zn finger	589..609	CDD:275368	6/19 (32%)
ZNF91	NP_003421.2	KRAB	13..73	CDD:214630
		C2H2 Zn finger	155..176	CDD:275368
		C2H2 Zn finger	212..232	CDD:275368	5/10 (50%)
		C2H2 Zn finger	240..260	CDD:275368	4/19 (21%)
		C2H2 Zn finger	268..288	CDD:275368	9/23 (39%)
		zf-H2C2_2	281..305	CDD:463886	10/23 (43%)
		C2H2 Zn finger	296..316	CDD:275368	5/19 (26%)
		COG5048	320..708	CDD:227381	98/283 (35%)
		C2H2 Zn finger	324..344	CDD:275368	8/20 (40%)
		C2H2 Zn finger	352..372	CDD:275368	6/19 (32%)
		C2H2 Zn finger	380..400	CDD:275368	5/19 (26%)
		C2H2 Zn finger	408..428	CDD:275368	7/19 (37%)
		C2H2 Zn finger	436..456	CDD:275368	5/20 (25%)
		C2H2 Zn finger	464..484	CDD:275368	4/19 (21%)
		C2H2 Zn finger	492..512	CDD:275368	5/19 (26%)
		C2H2 Zn finger	520..540	CDD:275368	7/20 (35%)
		C2H2 Zn finger	548..568	CDD:275368	1/19 (5%)
		C2H2 Zn finger	576..596	CDD:275368	6/19 (32%)
		C2H2 Zn finger	604..624	CDD:275368
		COG5048	628..1069	CDD:227381
		C2H2 Zn finger	632..652	CDD:275368
		C2H2 Zn finger	660..680	CDD:275368
		C2H2 Zn finger	688..708	CDD:275368
		C2H2 Zn finger	716..736	CDD:275368
		C2H2 Zn finger	744..764	CDD:275368
		C2H2 Zn finger	772..792	CDD:275368
		C2H2 Zn finger	800..820	CDD:275368
		C2H2 Zn finger	828..848	CDD:275368
		C2H2 Zn finger	856..876	CDD:275368
		C2H2 Zn finger	885..904	CDD:275368
		C2H2 Zn finger	912..932	CDD:275368
		C2H2 Zn finger	940..960	CDD:275368
		C2H2 Zn finger	968..988	CDD:275368
		C2H2 Zn finger	996..1016	CDD:275368
		C2H2 Zn finger	1024..1044	CDD:275368
		C2H2 Zn finger	1052..1072	CDD:275368
		SFP1	<1075..1154	CDD:227516
		C2H2 Zn finger	1080..1100	CDD:275368
		C2H2 Zn finger	1108..1128	CDD:275368
		C2H2 Zn finger	1136..1156	CDD:275368