DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CTCF and ZNF41

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_001311084.1	Gene:	ZNF41 / 7592	HGNCID:	13107	Length:	821	Species:	Homo sapiens

Alignment Length:	342	Identity:	115/342 - (33%)
Similarity:	161/342 - (47%)	Gaps:	18/342 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   278 KTASSTSQNSNASGHKYSCPHCPYTASKKFLITRHSRSHDVEPSFKCSICERSFRSNVGLQNHIN 342
            |:..:|.|..:.....|.|..|..:.:||..:..|.|.|..|..:.|:.|.:.|.....|..|..
Human   493 KSHFNTHQRIHTGEKPYECSDCGKSFTKKSQLHVHQRIHTGEKPYICTECGKVFTHRTNLTTHQK 557

  Fly   343 THMGNKPHKCKLCESAFTTSGELVRHTRYKHTKEKPHKCTECTYASVELTKLRRHMTCHTGERPY 407
            ||.|.||:.|..|..|||....|::|.: .||.|||:||..|..|.:..::|:.|...|.|||.|
Human   558 THTGEKPYMCAECGKAFTDQSNLIKHQK-THTGEKPYKCNGCGKAFIWKSRLKIHQKSHIGERHY 621

  Fly   408 QCPHCTYASQDMFKLKRHMVIHTGEKKYQCDICKSRFTQSNSLKAHKLIHSVVDKPVFQCNYCPT 472
            :|..|..|......|..|..||||||.|.|..|...|.|.:...||..||: .:|| ::|:.|..
Human   622 ECKDCGKAFIQKSTLSVHQRIHTGEKPYVCPECGKAFIQKSHFIAHHRIHT-GEKP-YECSDCGK 684

  Fly   473 TCGRKADLRVHIKHMHTSDVPMTCRRCGQQLPDRYQYKLHVKSHEGEKCYSCKLCSYASVTQRHL 537
            ...:|:.||||.| :||.:.|..|..||:...||.....|.|.|..||.|.|..|......:..|
Human   685 CFTKKSQLRVHQK-IHTGEKPNICAECGKAFTDRSNLITHQKIHTREKPYECGDCGKTFTWKSRL 748

  Fly   538 ASHMLIHLDEKPFHCDQCPQAFRQRQLLRRHMNLVHNEEYQPPEPREKLHKCPSCPREFTHKGNL 602
            ..|...|..|:.:.|.:|.:||.|:..|..| .::|.        .:|.:.|..|.:.||.:.||
Human   749 NIHQKSHTGERHYECSKCGKAFIQKATLSMH-QIIHT--------GKKPYACTECQKAFTDRSNL 804

  Fly   603 MRHMETHDDSANAREKR 619
            ::|.:.|     :.|||
Human   805 IKHQKMH-----SGEKR 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226
		C2H2 Zn finger	296..316	CDD:275368	6/19 (32%)
		COG5048	321..>621	CDD:227381	103/299 (34%)
		zf-C2H2	322..344	CDD:278523	5/21 (24%)
		C2H2 Zn finger	324..344	CDD:275368	5/19 (26%)
		zf-H2C2_2	337..361	CDD:290200	11/23 (48%)
		C2H2 Zn finger	352..373	CDD:275368	7/20 (35%)
		C2H2 Zn finger	381..401	CDD:275368	5/19 (26%)
		zf-H2C2_2	394..415	CDD:290200	9/20 (45%)
		C2H2 Zn finger	409..429	CDD:275368	5/19 (26%)
		zf-H2C2_2	422..446	CDD:290200	12/23 (52%)
		C2H2 Zn finger	437..457	CDD:275368	6/19 (32%)
		C2H2 Zn finger	467..485	CDD:275368	7/17 (41%)
		C2H2 Zn finger	496..516	CDD:275370	7/19 (37%)
		C2H2 Zn finger	524..544	CDD:275368	4/19 (21%)
		zf-H2C2_2	536..561	CDD:290200	8/24 (33%)
		C2H2 Zn finger	552..573	CDD:275368	7/20 (35%)
		zf-C2H2	587..609	CDD:278523	7/21 (33%)
		C2H2 Zn finger	589..609	CDD:275368	7/19 (37%)
ZNF41	NP_001311084.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55
		KRAB	69..129	CDD:214630
		KRAB	69..108	CDD:279668
		C2H2 Zn finger	315..335	CDD:275368
		COG5048	346..768	CDD:227381	97/278 (35%)
		C2H2 Zn finger	371..391	CDD:275368
		zf-H2C2_2	383..406	CDD:290200
		C2H2 Zn finger	399..419	CDD:275368
		zf-H2C2_2	411..436	CDD:290200
		C2H2 Zn finger	427..447	CDD:275368
		zf-H2C2_2	439..464	CDD:290200
		C2H2 Zn finger	455..475	CDD:275368
		zf-H2C2_2	467..492	CDD:290200
		C2H2 Zn finger	483..503	CDD:275368	3/9 (33%)
		zf-H2C2_2	495..519	CDD:290200	5/23 (22%)
		C2H2 Zn finger	511..531	CDD:275368	6/19 (32%)
		zf-H2C2_2	526..548	CDD:290200	7/21 (33%)
		C2H2 Zn finger	539..559	CDD:275368	5/19 (26%)
		zf-H2C2_2	551..575	CDD:290200	10/23 (43%)
		C2H2 Zn finger	567..587	CDD:275368	7/20 (35%)
		zf-H2C2_2	579..602	CDD:290200	10/23 (43%)
		C2H2 Zn finger	595..615	CDD:275368	5/19 (26%)
		C2H2 Zn finger	623..643	CDD:275368	5/19 (26%)
		zf-H2C2_2	636..660	CDD:290200	12/23 (52%)
		C2H2 Zn finger	651..671	CDD:275368	6/19 (32%)
		zf-C2H2	677..699	CDD:278523	8/22 (36%)
		C2H2 Zn finger	679..699	CDD:275368	8/20 (40%)
		C2H2 Zn finger	707..727	CDD:275368	7/19 (37%)
		zf-H2C2_2	719..743	CDD:290200	8/23 (35%)
		C2H2 Zn finger	735..755	CDD:275368	4/19 (21%)
		C2H2 Zn finger	763..783	CDD:275368	7/20 (35%)
		C2H2 Zn finger	791..811	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910