DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CTCF and ZNF23

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_001368913.1	Gene:	ZNF23 / 7571	HGNCID:	13023	Length:	686	Species:	Homo sapiens

Alignment Length:	611	Identity:	155/611 - (25%)
Similarity:	248/611 - (40%)	Gaps:	59/611 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 ENGAEAGGSKPMEEAEADLDHAEEAEEEEEDDEDKYFIDDEGNCYIKTTPKKQKELQKKLKQ--- 111
            |.|:|.|||.|: .|...|...:..:.:.::|..|...:.:.|...        |||:...|
Human    67 EGGSELGGSSPL-AAGTGLQGLQTVDIQTDNDLTKEMYEGKENVSF--------ELQRDFSQETD 122

  Fly   112 -AAAKPGKATRSVVSTATNKSINLRPAKSTPKATTSKPPPEPKAISVRPARAAAAKAKQSAMPPP 175
             :.|...:..:.|.|....|.........|.|..||   |..:....:.:.:..........|..
Human   123 FSEASLLEKQQEVHSAGNIKKEKSNTIDGTVKDETS---PVEECFFSQSSNSYQCHTITGEQPSG 184

  Fly   176 PALVVKVPAPRGRPRKNPVIPKPE-PMDLERELEELVDEPDISSMVTELSDYTVDEAAVEAATA- 238
            ...:.|..:...:..|:.:|...| |.    :.||||:.....|.:.:..:...:|...:.:..
Human   185 CTGLGKSISFDTKLVKHEIINSEERPF----KCEELVEPFRCDSQLIQHQENNTEEKPYQCSECG 245

  Fly   239 -TLTPNEAEVYEFEDNATTEDENADKKDVDFVLSNKEVKLKTASSTSQNSNASGHKYSCPHCPYT 302
             ..:.||..::.       :..::.:|....|...|.....:...|.|..::....|.|..|...
Human   246 KAFSINEKLIWH-------QRLHSGEKPFKCVECGKSFSYSSHYITHQTIHSGEKPYQCKMCGKA 303

  Fly   303 ASKKFLITRHSRSHDVEPSFKCSICERSFRSNVGLQNHINTHMGNKPHKCKLCESAFTTSGELVR 367
            .|....::||.|.|..|..::|..|...|..:.....|...|.|.||::|..|..||..:.:|::
Human   304 FSVNGSLSRHQRIHTGEKPYQCKECGNGFSCSSAYITHQRVHTGEKPYECNDCGKAFNVNAKLIQ 368

  Fly   368 HTRYKHTKEKPHKCTECTYASVELTKLRRHMTCHTGERPYQCPHCTYASQDMFKLKRHMVIHTGE 432
            |.|. ||.|||::|.||.......::||:|.:.||||:||||..|.....:..||.:|..|||||
Human   369 HQRI-HTGEKPYECNECGKGFRCSSQLRQHQSIHTGEKPYQCKECGKGFNNNTKLIQHQRIHTGE 432

  Fly   433 KKYQCDICKSRFTQSNSLKAHKLIHSVVDKPVFQCNYCPTTCGRKADLRVHIKHMHTSDVPMTCR 497
            |.|:|..|...|:....|..|:.||: .:|| ::||.|.......:..|.|:: :||.:.|..|.
Human   433 KPYECTECGKAFSVKGKLIQHQRIHT-GEKP-YECNECGKAFRCNSQFRQHLR-IHTGEKPYECN 494

  Fly   498 RCGQQLPDRYQYKLHVKSHEGEKCYSCKLCSYASVTQRHLASHMLIHLDEKPFHCDQCPQAFRQR 562
            .||:......:...|.:.|.|||.:.|..|.....::|:|..|..||..|||:.|.:|.:||...
Human   495 ECGKAFSVNGKLMRHQRIHTGEKPFECNECGRCFTSKRNLLDHHRIHTGEKPYQCKECGKAFSIN 559

  Fly   563 QLLRRHMNLVHNEE--------------------YQPPEPREKLHKCPSCPREFTHKGNLMRHME 607
            ..|.||.. :|..|                    :|.....||..:|..|.:.|....:|:||..
Human   560 AKLTRHQR-IHTGEKPFKCMECEKAFSCSSNYIVHQRIHTGEKPFQCKECGKAFHVNAHLIRHQR 623

  Fly   608 THDDSANAREKRRRLKLGRNVRLQKD 633
            :|    ...:..|.::.|:......|
Human   624 SH----TGEKPFRCVECGKGFSFSSD 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226	14/90 (16%)
		C2H2 Zn finger	296..316	CDD:275368	6/19 (32%)
		COG5048	321..>621	CDD:227381	99/319 (31%)
		zf-C2H2	322..344	CDD:278523	4/21 (19%)
		C2H2 Zn finger	324..344	CDD:275368	4/19 (21%)
		zf-H2C2_2	337..361	CDD:290200	9/23 (39%)
		C2H2 Zn finger	352..373	CDD:275368	7/20 (35%)
		C2H2 Zn finger	381..401	CDD:275368	6/19 (32%)
		zf-H2C2_2	394..415	CDD:290200	12/20 (60%)
		C2H2 Zn finger	409..429	CDD:275368	5/19 (26%)
		zf-H2C2_2	422..446	CDD:290200	12/23 (52%)
		C2H2 Zn finger	437..457	CDD:275368	5/19 (26%)
		C2H2 Zn finger	467..485	CDD:275368	5/17 (29%)
		C2H2 Zn finger	496..516	CDD:275370	4/19 (21%)
		C2H2 Zn finger	524..544	CDD:275368	5/19 (26%)
		zf-H2C2_2	536..561	CDD:290200	11/24 (46%)
		C2H2 Zn finger	552..573	CDD:275368	7/20 (35%)
		zf-C2H2	587..609	CDD:278523	6/21 (29%)
		C2H2 Zn finger	589..609	CDD:275368	6/19 (32%)
ZNF23	NP_001368913.1	KRAB	14..73	CDD:214630	3/5 (60%)
		C2H2 Zn finger	185..205	CDD:275368	2/19 (11%)
		C2H2 Zn finger	213..233	CDD:275368	5/19 (26%)
		COG5048	229..649	CDD:227381	119/433 (27%)
		C2H2 Zn finger	241..261	CDD:275368	2/26 (8%)
		C2H2 Zn finger	269..289	CDD:275368	4/19 (21%)
		C2H2 Zn finger	297..317	CDD:275368	6/19 (32%)
		C2H2 Zn finger	325..345	CDD:275368	4/19 (21%)
		C2H2 Zn finger	353..373	CDD:275368	7/20 (35%)
		C2H2 Zn finger	381..401	CDD:275368	6/19 (32%)
		C2H2 Zn finger	409..429	CDD:275368	5/19 (26%)
		C2H2 Zn finger	437..457	CDD:275368	5/19 (26%)
		C2H2 Zn finger	465..485	CDD:275368	5/20 (25%)
		C2H2 Zn finger	493..513	CDD:275368	4/19 (21%)
		C2H2 Zn finger	521..541	CDD:275368	5/19 (26%)
		C2H2 Zn finger	549..569	CDD:275368	7/20 (35%)
		C2H2 Zn finger	577..597	CDD:275368	1/19 (5%)
		C2H2 Zn finger	605..625	CDD:275368	6/19 (32%)
		C2H2 Zn finger	633..653	CDD:275368	2/13 (15%)
		C2H2 Zn finger	661..681	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000