DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CTCF and Zfp169

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	XP_011242711.1	Gene:	Zfp169 / 67911	MGIID:	1915161	Length:	732	Species:	Mus musculus

Alignment Length:	657	Identity:	168/657 - (25%)
Similarity:	245/657 - (37%)	Gaps:	165/657 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 DEGNCYIKTTPKKQK-ELQKKLKQAAAKPGKATRSVVSTATNKSINLRPAKSTPKATTSKPP--- 149
            |...|::...|.:.: ||:..|.           |.||.|:.:.:.:......|..|...||
Mouse    75 DGSGCFLDLCPAEPRTELEPSLS-----------SPVSFASPEVLRVCVLNGPPSQTFPSPPAGS 128

  Fly   150 ---------------------------PEPKAI---SVRPARAAAA-----KAKQSAM---PPPP 176
                                       ..|..|   ...|.:..||     .:||:.:   |...
Mouse   129 NFQSEAPGCSSNEGGEERDSSDALLQRTSPTRILKTFFSPCQDQAAYWVEGDSKQTDLGLAPEEA 193

  Fly   177 ALVVKVP------------APRG--------RPRKNPVIP--------KPEPMDLERELEELVDE 213
            ..|:|.|            .|.|        .|:|:.|.|        ..:.|.|:|  .:.|::
Mouse   194 VTVLKGPDESASGAVLHGAFPLGLDDVTNLFSPQKHHVFPDCGGGFCQSSDLMKLQR--MDGVEK 256

  Fly   214 PDISSMVTELSDYTVDEAAVE-AATATLTPNEAEVYEFEDNATTEDENADKKDVDFVLSNKEV-- 275
            |           |:..|...: |..|:||.::.: :..|.....|:.......|..:.|:|::
Mouse   257 P-----------YSCSECGHQFAQKASLTVHQRK-HSGEKPHVCEECGRGFMYVSSLNSHKKIIH 309

  Fly   276 ---------------KLKTASSTSQNSNASGHKYSCPHCPYTASKKFLITRHSRSHDVEPSFKCS 325
                           :.|......|.::.....:.||.|.....:|..:.:||.||..:..|.||
Mouse   310 SGESPLVCPECGRGFRQKIDLLLHQRTHLDKKPFVCPECGRGFCRKASLLQHSWSHSGDNPFICS 374

  Fly   326 ICERSFRSNVGLQNHINTHMGNKPHKCKLCESAFTTSGELVRHTRYKHTKEKPHKCTECTYASVE 390
            :|.|.||....|..|..||.|.|||.|..|...|...|.|:||.: .||.|||..|.:|.::..:
Mouse   375 VCGRGFRLLSRLLTHQVTHSGEKPHVCPDCGQRFGQKGTLMRHQK-THTGEKPFVCRQCGWSFTQ 438

  Fly   391 LTKLRRHMTCHT----------------------------GERPYQCPHCTYASQDMFKLKRHMV 427
            ...|.||...||                            ||:||.||.|.......|.|..|..
Mouse   439 KVNLIRHQRIHTEVKPFLCPECGRAFEFKSLLTRHRKTHMGEKPYVCPQCGRGFSQKFNLIGHQR 503

  Fly   428 IHTGEKKYQCDICKSRFTQSNSLKAHKLIHSVVDKPVFQCNYCPTTCGRKADLRVHIKHMHTSDV 492
            |||||..:.|..|...|.:.:.|..|:..|:..:|| :||..|..|...|:.|..|.| :||.:.
Mouse   504 IHTGELPFLCPECGRAFVKQSMLIRHQRTHAGWEKP-YQCPECGRTFEFKSLLTRHQK-IHTGEK 566

  Fly   493 PMTCRRCGQQLPDRYQYKLHVKSHEGEKCYSCKLCSYASVTQRHLASHMLIHLDEKPFHCDQCPQ 557
            |..|.:||:....::....|.|:|.|||.|:|..|......:.:||.|..||..||||.|.:|.:
Mouse   567 PYVCPQCGRGFSQKFNLIGHQKTHTGEKPYACPQCGQRFRQKFNLARHQRIHTGEKPFLCAECGR 631

  Fly   558 AFRQRQLLRRHMNLVHNEE--------------------YQPPEPREKLHKCPSCPREFTHKGNL 602
            ||.::..|.||.. .|.||                    :|.....||.:.||.|.:.|:.|.||
Mouse   632 AFGKKVSLIRHQR-THGEEKPYQCTECGRAFEFKSLFIRHQKTHTGEKPYVCPECGKAFSQKFNL 695

  Fly   603 MRHMETH 609
            :.|..:|
Mouse   696 IGHQRSH 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226	27/158 (17%)
		C2H2 Zn finger	296..316	CDD:275368	6/19 (32%)
		COG5048	321..>621	CDD:227381	111/337 (33%)
		zf-C2H2	322..344	CDD:278523	9/21 (43%)
		C2H2 Zn finger	324..344	CDD:275368	8/19 (42%)
		zf-H2C2_2	337..361	CDD:290200	11/23 (48%)
		C2H2 Zn finger	352..373	CDD:275368	7/20 (35%)
		C2H2 Zn finger	381..401	CDD:275368	5/19 (26%)
		zf-H2C2_2	394..415	CDD:290200	12/48 (25%)
		C2H2 Zn finger	409..429	CDD:275368	6/19 (32%)
		zf-H2C2_2	422..446	CDD:290200	10/23 (43%)
		C2H2 Zn finger	437..457	CDD:275368	5/19 (26%)
		C2H2 Zn finger	467..485	CDD:275368	6/17 (35%)
		C2H2 Zn finger	496..516	CDD:275370	5/19 (26%)
		C2H2 Zn finger	524..544	CDD:275368	5/19 (26%)
		zf-H2C2_2	536..561	CDD:290200	13/24 (54%)
		C2H2 Zn finger	552..573	CDD:275368	7/20 (35%)
		zf-C2H2	587..609	CDD:278523	8/21 (38%)
		C2H2 Zn finger	589..609	CDD:275368	8/19 (42%)
Zfp169	XP_011242711.1	KRAB	14..73	CDD:214630
		C2H2 Zn finger	233..252	CDD:275368	4/20 (20%)
		COG5048	256..727	CDD:227381	133/463 (29%)
		C2H2 Zn finger	260..280	CDD:275368	5/20 (25%)
		C2H2 Zn finger	288..309	CDD:275368	4/20 (20%)
		C2H2 Zn finger	317..337	CDD:275368	2/19 (11%)
		C2H2 Zn finger	345..365	CDD:275368	6/19 (32%)
		C2H2 Zn finger	373..393	CDD:275368	8/19 (42%)
		C2H2 Zn finger	401..421	CDD:275368	7/20 (35%)
		C2H2 Zn finger	429..449	CDD:275368	5/19 (26%)
		C2H2 Zn finger	457..477	CDD:275368	0/19 (0%)
		C2H2 Zn finger	485..505	CDD:275368	6/19 (32%)
		C2H2 Zn finger	513..533	CDD:275368	5/19 (26%)
		C2H2 Zn finger	542..562	CDD:275368	7/20 (35%)
		C2H2 Zn finger	570..590	CDD:275368	5/19 (26%)
		C2H2 Zn finger	598..618	CDD:275368	5/19 (26%)
		C2H2 Zn finger	626..646	CDD:275368	7/20 (35%)
		C2H2 Zn finger	654..674	CDD:275368	1/19 (5%)
		C2H2 Zn finger	682..702	CDD:275368	8/19 (42%)
		C2H2 Zn finger	710..730	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910