DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CTCF and znf1068

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_001104669.1	Gene:	znf1068 / 569852	ZFINID:	ZDB-GENE-080215-12	Length:	419	Species:	Danio rerio

Alignment Length:	440	Identity:	126/440 - (28%)
Similarity:	195/440 - (44%)	Gaps:	58/440 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   197 KPEPMDLERE------LEELVDEPDISSMVTELSDYTVDEAAVEAATATLTPNEAEVYEFEDN-A 254
            |.|..|::.|      .|:|.::.|:..:..|                |...|:.|..:||.: .
Zfish     5 KEESEDVKIEETFTVKQEDLQEQTDLMVLKEE----------------THQQNKMEEKQFEKHQE 53

  Fly   255 TTEDENADKKDVDFVLSNKEVKLKTASSTSQNSNASGHK-------------------YSCPHCP 300
            ||.||   |..:....|::....|:.|:.:......|::                   |:|..|.
Zfish    54 TTTDE---KPTLTKKTSSRRRPRKSESACNLTCRQCGNRFRRKHNLQIHMRIHTGEKPYTCQQCG 115

  Fly   301 YTASKKFLITRHSRSHDVEPSFKCSICERSFRSNVGLQNHINTHMGNKPHKCKLCESAFTTSGEL 365
            ........:..|.|.|..|..:.|..|.:||:.|..|:.|:.||.|.:|:.|:.|...|.|:|.|
Zfish   116 QCFCTSGNLVVHMRLHTGEKPYSCPQCGKSFKHNGNLKVHMRTHTGERPYTCQQCGQCFYTTGNL 180

  Fly   366 VRHTRYKHTKEKPHKCTECTYASVELTKLRRHMTCHTGERPYQCPHCTYASQDMFKLKRHMVIHT 430
            ..|.|. ||.|:|:.|.:|..:..:...|..||..|||||||.|..|..:......|..||.|||
Zfish   181 AAHMRI-HTGERPYTCQQCGKSFYQSANLAAHMRIHTGERPYTCQQCGKSFYQSANLVVHMRIHT 244

  Fly   431 GEKKYQCDICKSRFTQSNSLKAHKLIHSVVDKPVFQCNYCPTTCGRKADLRVHIKHMHTSDVPMT 495
            ||:.|.|..|...|.|:::|:||...|:  ....|.|..|..:..:|.||.:|:: :||.:.|.|
Zfish   245 GERPYSCPQCGKSFKQNSNLEAHIRTHN--GGRSFTCPQCGKSFAQKQDLDLHMR-IHTGEKPYT 306

  Fly   496 CRRCGQQLPDRYQYKLHVKSHEGEKCYSCKLCSYASVTQRHLASHMLIHLDEKPFHCDQCPQAFR 560
            |..||:....:.....|:.||.|||.::|..|..:..|:..|.:||..|.....|.||||.::..
Zfish   307 CTECGKSFRCKSALNNHMISHTGEKPFTCAQCGKSFTTKTSLKNHMNGHTGTIVFTCDQCGKSLT 371

  Fly   561 QRQLLRRHMNLVHNEEYQPPEPREKLHKCPSCPREFTHKGNLMRHMETHD 610
            ::..:|.||.....|:.         .:|..|.:.|.:|.:|..|::.|:
Zfish   372 RKDTIRNHMKTHSGEDG---------FRCSECGKGFKYKKSLNTHIKLHN 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226	3/8 (38%)
		C2H2 Zn finger	296..316	CDD:275368	4/19 (21%)
		COG5048	321..>621	CDD:227381	97/290 (33%)
		zf-C2H2	322..344	CDD:278523	7/21 (33%)
		C2H2 Zn finger	324..344	CDD:275368	7/19 (37%)
		zf-H2C2_2	337..361	CDD:290200	9/23 (39%)
		C2H2 Zn finger	352..373	CDD:275368	8/20 (40%)
		C2H2 Zn finger	381..401	CDD:275368	5/19 (26%)
		zf-H2C2_2	394..415	CDD:290200	12/20 (60%)
		C2H2 Zn finger	409..429	CDD:275368	5/19 (26%)
		zf-H2C2_2	422..446	CDD:290200	12/23 (52%)
		C2H2 Zn finger	437..457	CDD:275368	7/19 (37%)
		C2H2 Zn finger	467..485	CDD:275368	6/17 (35%)
		C2H2 Zn finger	496..516	CDD:275370	4/19 (21%)
		C2H2 Zn finger	524..544	CDD:275368	6/19 (32%)
		zf-H2C2_2	536..561	CDD:290200	9/24 (38%)
		C2H2 Zn finger	552..573	CDD:275368	7/20 (35%)
		zf-C2H2	587..609	CDD:278523	6/21 (29%)
		C2H2 Zn finger	589..609	CDD:275368	6/19 (32%)
znf1068	NP_001104669.1	C2H2 Zn finger	83..103	CDD:275368	1/19 (5%)
		zf-H2C2_2	95..118	CDD:290200	3/22 (14%)
		COG5048	107..>411	CDD:227381	103/316 (33%)
		C2H2 Zn finger	111..131	CDD:275368	4/19 (21%)
		zf-H2C2_2	123..148	CDD:290200	8/24 (33%)
		C2H2 Zn finger	139..159	CDD:275368	7/19 (37%)
		zf-H2C2_2	151..176	CDD:290200	9/24 (38%)
		C2H2 Zn finger	167..187	CDD:275368	8/20 (40%)
		zf-H2C2_2	179..202	CDD:290200	9/23 (39%)
		C2H2 Zn finger	195..215	CDD:275368	5/19 (26%)
		zf-H2C2_2	207..230	CDD:290200	12/22 (55%)
		C2H2 Zn finger	223..243	CDD:275368	5/19 (26%)
		zf-H2C2_2	235..260	CDD:290200	12/24 (50%)
		C2H2 Zn finger	251..271	CDD:275368	7/19 (37%)
		C2H2 Zn finger	279..299	CDD:275368	6/20 (30%)
		zf-H2C2_2	291..316	CDD:290200	10/25 (40%)
		C2H2 Zn finger	307..327	CDD:275368	4/19 (21%)
		zf-H2C2_2	319..344	CDD:290200	8/24 (33%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000