DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CTCF and znf1041

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_001107903.1	Gene:	znf1041 / 565096	ZFINID:	ZDB-GENE-080213-11	Length:	443	Species:	Danio rerio

Alignment Length:	443	Identity:	131/443 - (29%)
Similarity:	190/443 - (42%)	Gaps:	57/443 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 ELSDYTVDEAAVEAATATLTPNEAEVYEFEDNATTEDE-----NADKKDVDFVLSNK-EVKLKTA 280
            |..|..::|        |.|..|.::.|..|....::|     ..::|..|.....| .:..||:
Zfish     7 ESEDVKIEE--------TFTVKEEDLQEQTDPIVLKEETHQWNEMEEKHQDMTTDEKPTLTEKTS 63

  Fly   281 S--------------------STSQNSNASGH--------KYSCPHCPYTASKKFLITRHSRSHD 317
            |                    |.||..|...|        .|:|..|..:..:|.....|.|.|.
Zfish    64 SQGRPRKSKSRCNVSCKQSRKSFSQKPNLDVHMRVHTREKPYNCEQCGKSFGQKQSFKIHMRIHT 128

  Fly   318 VEPSFKCSICERSFRSNVGLQNHINTHMGNKPHKCKLCESAFTTSGELVRHTRYKHTKEKPHKCT 382
            .|..:.|..|.:||........|...|.|.:|:.|:.|..:|.|.|.|..|.|. ||.|||:.|.
Zfish   129 GERPYTCQQCGQSFYHAGNFAVHRRIHTGERPYTCQQCGQSFYTGGNLAVHMRI-HTGEKPYSCI 192

  Fly   383 ECTYASVELTKLRRHMTCHTGERPYQCPHCTYASQDMFKLKRHMVIHTGEKKYQCDICKSRFTQS 447
            :|..:..:...|:.||..|||||||.|..|..:........:||.|||||:.|.|..|...|.||
Zfish   193 QCGKSFKQNGTLKVHMRSHTGERPYTCQLCGKSFYTTGNFAQHMRIHTGERPYTCQQCGKSFYQS 257

  Fly   448 NSLKAHKLIHSVVDKPVFQCNYCPTTCGRKADLRVHIKHMHTSDVPMTCRRCGQQLPDRYQYKLH 512
            .:|.||..||: .:|| :.|..|..:..:.::|..||| .|..:..:||.:|.:....:...::|
Zfish   258 ANLAAHMRIHT-GEKP-YSCPQCGKSFKQNSNLEAHIK-THNRERSITCTQCKKSFAQKQDLEIH 319

  Fly   513 VKSHEGEKCYSCKLCSYASVTQRHLASHMLIHLDEKPFHCDQCPQAFRQRQLLRRHMNLVHNEEY 577
            ::.|.|||.|:|..|......:..|..||:.|..||||.|.||.::|..:..|..||| .|....
Zfish   320 MRIHTGEKPYTCTECGKGFTCKGTLKHHMISHTGEKPFACAQCGKSFTTKASLTIHMN-GHTGTI 383

  Fly   578 QPPEPREKLHKCPSCPREFTHKGNLMRHMETH--DDSANAREKRRRLKLGRNV 628
                    :..|..|.:..|.|.::.|||:||  :|.....|..:..|..|::
Zfish   384 --------VFTCDQCGKTLTRKDSIKRHMKTHSGEDPFRCSECGKSFKHKRSL 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226
		C2H2 Zn finger	296..316	CDD:275368	5/19 (26%)
		COG5048	321..>621	CDD:227381	101/301 (34%)
		zf-C2H2	322..344	CDD:278523	5/21 (24%)
		C2H2 Zn finger	324..344	CDD:275368	5/19 (26%)
		zf-H2C2_2	337..361	CDD:290200	7/23 (30%)
		C2H2 Zn finger	352..373	CDD:275368	8/20 (40%)
		C2H2 Zn finger	381..401	CDD:275368	5/19 (26%)
		zf-H2C2_2	394..415	CDD:290200	12/20 (60%)
		C2H2 Zn finger	409..429	CDD:275368	4/19 (21%)
		zf-H2C2_2	422..446	CDD:290200	11/23 (48%)
		C2H2 Zn finger	437..457	CDD:275368	8/19 (42%)
		C2H2 Zn finger	467..485	CDD:275368	4/17 (24%)
		C2H2 Zn finger	496..516	CDD:275370	3/19 (16%)
		C2H2 Zn finger	524..544	CDD:275368	5/19 (26%)
		zf-H2C2_2	536..561	CDD:290200	12/24 (50%)
		C2H2 Zn finger	552..573	CDD:275368	8/20 (40%)
		zf-C2H2	587..609	CDD:278523	7/21 (33%)
		C2H2 Zn finger	589..609	CDD:275368	7/19 (37%)
znf1041	NP_001107903.1	C2H2 Zn finger	79..99	CDD:275368	5/19 (26%)
		zf-H2C2_2	91..114	CDD:290200	5/22 (23%)
		COG5048	103..>429	CDD:227381	111/339 (33%)
		C2H2 Zn finger	107..127	CDD:275368	5/19 (26%)
		zf-H2C2_2	119..142	CDD:290200	6/22 (27%)
		C2H2 Zn finger	135..155	CDD:275368	5/19 (26%)
		C2H2 Zn finger	163..183	CDD:275368	8/20 (40%)
		zf-H2C2_2	175..200	CDD:290200	10/25 (40%)
		C2H2 Zn finger	191..211	CDD:275368	5/19 (26%)
		zf-H2C2_2	204..228	CDD:290200	12/23 (52%)
		C2H2 Zn finger	219..239	CDD:275368	4/19 (21%)
		zf-H2C2_2	231..254	CDD:290200	10/22 (45%)
		C2H2 Zn finger	247..267	CDD:275368	8/19 (42%)
		zf-H2C2_2	259..284	CDD:290200	9/26 (35%)
		C2H2 Zn finger	275..295	CDD:275368	6/20 (30%)
		C2H2 Zn finger	303..323	CDD:275368	3/19 (16%)
		zf-H2C2_2	315..340	CDD:290200	8/24 (33%)
		C2H2 Zn finger	331..351	CDD:275368	5/19 (26%)
		zf-H2C2_2	344..368	CDD:290200	12/23 (52%)
		C2H2 Zn finger	359..379	CDD:275368	8/20 (40%)
		C2H2 Zn finger	387..407	CDD:275368	7/19 (37%)
		zf-H2C2_2	399..424	CDD:290200	7/24 (29%)
		C2H2 Zn finger	415..435	CDD:275368	3/14 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000