DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CTCF and znf1161

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_001232021.1	Gene:	znf1161 / 559851	ZFINID:	ZDB-GENE-050420-11	Length:	430	Species:	Danio rerio

Alignment Length:	427	Identity:	131/427 - (30%)
Similarity:	190/427 - (44%)	Gaps:	58/427 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 TELSDYTVDEAAVEAATATLTPNEAEVYEFEDNATTEDENADKKDVDFVLSNKE--------VKL 277
            :|||..|:.|...:    :|..:..::.:.|.....::|:.:..|   ||..||        ||.
Zfish    14 SELSSATISERQRQ----SLLKDSEKMSDPEPCRIKQEESEELID---VLVEKESEAEEKHQVKS 71

  Fly   278 KTASST--SQNSNASGHKYSCPHCPYTASKKFLITRHSRSHDVEPSFKCSICERSFRSNVGLQNH 340
            :|.:.|  ..||......::|..|..:.|:|..:..|...|..|..:.||.|.:.|..:..|:.|
Zfish    72 ETETRTKDKHNSIMKRKDFTCTQCGRSFSQKHDLNVHMLIHIGEKPYMCSHCGKRFNRSGHLKRH 136

  Fly   341 INTHMGNKPHKCKLCESAFTTSGELVRHTRYKHTKEKPHKCTECTYASVELTKLRRHMTCHTGER 405
            ...|.|.|||||..|...|....:|..|.|. ||.|:|:.|:||..:...|:.|:.|...||||:
Zfish   137 EMMHTGEKPHKCDQCGKLFPWPSDLKTHLRV-HTNERPYSCSECGKSFTYLSHLKGHQKIHTGEK 200

  Fly   406 PYQCPHCTYASQDMFKLKRHMVIHTGEKKYQCDICKSRFTQSNSLKAHKLIHSVVDKPVFQCNYC 470
            .:.|..|..:......||:|.:||||||.:.|.:|...|.||:.|..|||||: .|| ..:|:.|
Zfish   201 AFVCSECGKSFIKSGDLKQHQIIHTGEKPFICTVCGMSFRQSSHLHQHKLIHT-GDK-THKCDQC 263

  Fly   471 PTTCGRKADLRVHIKHMHTSDVPMTCRRCGQQLPDRYQYKL------------------------ 511
            ..|..|.:||:.|:. :||.:.|.:|..||:......:..|
Zfish   264 GKTFLRTSDLKNHLS-VHTQEKPHSCSECGKSFKRLRELNLHQQMHTGVREFVCIECEKSFIRAR 327

  Fly   512 ----HVKSHEGEKCYSCKLCSYASVTQRHLASHMLIHLDEKPFHCDQCPQAFRQRQLLRRHMNLV 572
                |.|.|.|||...|..|....:.:.||.:|...|.:|||:.|.||.::||...||..|: |.
Zfish   328 DLRRHQKIHTGEKPNKCSHCDKRFIQKAHLKTHESTHTEEKPYTCAQCGKSFRASFLLNLHI-LR 391

  Fly   573 HNEEYQPPEPREKLHKCPSCPREFTHKGNLMRHMETH 609
            |.|        .|.|||..|.:.|.....|.:|...|
Zfish   392 HAE--------RKNHKCDQCDKTFLRASELRKHFLAH 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226
		C2H2 Zn finger	296..316	CDD:275368	5/19 (26%)
		COG5048	321..>621	CDD:227381	105/317 (33%)
		zf-C2H2	322..344	CDD:278523	6/21 (29%)
		C2H2 Zn finger	324..344	CDD:275368	6/19 (32%)
		zf-H2C2_2	337..361	CDD:290200	11/23 (48%)
		C2H2 Zn finger	352..373	CDD:275368	6/20 (30%)
		C2H2 Zn finger	381..401	CDD:275368	6/19 (32%)
		zf-H2C2_2	394..415	CDD:290200	8/20 (40%)
		C2H2 Zn finger	409..429	CDD:275368	5/19 (26%)
		zf-H2C2_2	422..446	CDD:290200	12/23 (52%)
		C2H2 Zn finger	437..457	CDD:275368	9/19 (47%)
		C2H2 Zn finger	467..485	CDD:275368	7/17 (41%)
		C2H2 Zn finger	496..516	CDD:275370	6/47 (13%)
		C2H2 Zn finger	524..544	CDD:275368	5/19 (26%)
		zf-H2C2_2	536..561	CDD:290200	11/24 (46%)
		C2H2 Zn finger	552..573	CDD:275368	9/20 (45%)
		zf-C2H2	587..609	CDD:278523	7/21 (33%)
		C2H2 Zn finger	589..609	CDD:275368	5/19 (26%)
znf1161	NP_001232021.1	C2H2 Zn finger	92..112	CDD:275368	5/19 (26%)
		zf-H2C2_2	104..129	CDD:290200	7/24 (29%)
		C2H2 Zn finger	120..140	CDD:275368	6/19 (32%)
		zf-H2C2_2	132..155	CDD:290200	10/22 (45%)
		C2H2 Zn finger	148..168	CDD:275368	6/20 (30%)
		zf-H2C2_2	160..185	CDD:290200	10/25 (40%)
		COG5048	<173..332	CDD:227381	49/161 (30%)
		C2H2 Zn finger	176..196	CDD:275368	6/19 (32%)
		C2H2 Zn finger	204..224	CDD:275368	5/19 (26%)
		C2H2 Zn finger	232..252	CDD:275368	9/19 (47%)
		C2H2 Zn finger	260..280	CDD:275368	7/20 (35%)
		C2H2 Zn finger	288..308	CDD:275368	4/19 (21%)
		C2H2 Zn finger	316..336	CDD:275368	2/19 (11%)
		C2H2 Zn finger	344..364	CDD:275368	5/19 (26%)
		C2H2 Zn finger	372..392	CDD:275368	9/20 (45%)
		C2H2 Zn finger	400..416	CDD:275368	4/15 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000