DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CTCF and ZFP64

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_060667.2	Gene:	ZFP64 / 55734	HGNCID:	15940	Length:	681	Species:	Homo sapiens

Alignment Length:	420	Identity:	111/420 - (26%)
Similarity:	185/420 - (44%)	Gaps:	51/420 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 SMVTELSDYTVDEAAVEAATATLTPNEAEVYEFEDNATTEDENADKKDVDFVLSNKEVKLKTASS 282
            |.|..:|:.||.....:..|.|:              |:|.:.......:||.   |...:|...
Human    65 STVQFVSEETVPATQTQTTTRTI--------------TSETQTITVSAPEFVF---EHGYQTYLP 112

  Fly   283 TSQNSNASGHKYSCPHCPYTASKKFLITRHSRSHDVEPSFKCSICERSFRSNVG---LQNHINTH 344
            |..|.|.:....|.|     |..:   |:...:...:....|......|::..|   ::.|:..|
Human   113 TESNENQTATVISLP-----AKSR---TKKPTTPPAQKRLNCCYPGCQFKTAYGMKDMERHLKIH 169

  Fly   345 MGNKPHKCKLCESAFTTSGELVRHTRYKHTKEKPHKCTECTYASVELTKLRRHMTCHTGERPYQC 409
            .|:|||||::|...|:...:|..|.|. ||..||:||..|.||:.:.:.|.:|:..|:.|||::|
Human   170 TGDKPHKCEVCGKCFSRKDKLKTHMRC-HTGVKPYKCKTCDYAAADSSSLNKHLRIHSDERPFKC 233

  Fly   410 PHCTYASQDMFKLKRHMVIHTGEKKYQCDICKSRFTQSNSLKAHKLIHSVVDKPVFQCNYCPTTC 474
            ..|.|||::..:|..|:..|||:..:||.:|.::|..|:.||.|..:|| .:|| |:|.:|...|
Human   234 QICPYASRNSSQLTVHLRSHTGDAPFQCWLCSAKFKISSDLKRHMRVHS-GEKP-FKCEFCNVRC 296

  Fly   475 GRKADLRVHIKHMHTSDVPMTCRRCGQQLPDRYQYKLHVKSHEGEKCYSCKLCSYASVTQRHLAS 539
            ..|.:|:.||:..|:.: ...|..|......:...:.|.:.|:.|....|..|||:..::..|..
Human   297 TMKGNLKSHIRIKHSGN-NFKCPHCDFLGDSKATLRKHSRVHQSEHPEKCSECSYSCSSKAALRI 360

  Fly   540 HMLIHLDEKPFHCDQCPQAFRQRQLLRRHMNLVHNE------------------EYQPPEPREKL 586
            |..||..::||.|:.|....:|...|.:||...|.:                  :....:.::..
Human   361 HERIHCTDRPFKCNYCSFDTKQPSNLSKHMKKFHGDMVKTEALERKDTGRQSSRQVAKLDAKKSF 425

  Fly   587 HKCPSCPREFTHKGNLMRHMETHDDSANAR 616
            | |..|...|..:.:|..|...|.:.:.::
Human   426 H-CDICDASFMREDSLRSHKRQHSEYSESK 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226
		C2H2 Zn finger	296..316	CDD:275368	3/19 (16%)
		COG5048	321..>621	CDD:227381	91/317 (29%)
		zf-C2H2	322..344	CDD:278523	4/24 (17%)
		C2H2 Zn finger	324..344	CDD:275368	4/22 (18%)
		zf-H2C2_2	337..361	CDD:290200	10/23 (43%)
		C2H2 Zn finger	352..373	CDD:275368	6/20 (30%)
		C2H2 Zn finger	381..401	CDD:275368	6/19 (32%)
		zf-H2C2_2	394..415	CDD:290200	8/20 (40%)
		C2H2 Zn finger	409..429	CDD:275368	7/19 (37%)
		zf-H2C2_2	422..446	CDD:290200	9/23 (39%)
		C2H2 Zn finger	437..457	CDD:275368	7/19 (37%)
		C2H2 Zn finger	467..485	CDD:275368	6/17 (35%)
		C2H2 Zn finger	496..516	CDD:275370	3/19 (16%)
		C2H2 Zn finger	524..544	CDD:275368	6/19 (32%)
		zf-H2C2_2	536..561	CDD:290200	8/24 (33%)
		C2H2 Zn finger	552..573	CDD:275368	6/20 (30%)
		zf-C2H2	587..609	CDD:278523	6/21 (29%)
		C2H2 Zn finger	589..609	CDD:275368	5/19 (26%)
ZFP64	NP_060667.2	COG5048	<151..450	CDD:227381	90/303 (30%)
		zf-H2C2_2	161..186	CDD:290200	10/24 (42%)
		C2H2 Zn finger	177..197	CDD:275368	6/20 (30%)
		zf-H2C2_2	190..211	CDD:290200	10/21 (48%)
		C2H2 Zn finger	205..225	CDD:275368	6/19 (32%)
		zf-H2C2_2	217..239	CDD:290200	8/21 (38%)
		C2H2 Zn finger	233..253	CDD:275368	7/19 (37%)
		C2H2 Zn finger	261..281	CDD:275368	7/19 (37%)
		zf-H2C2_2	273..297	CDD:290200	10/25 (40%)
		C2H2 Zn finger	289..308	CDD:275368	7/18 (39%)
		C2H2 Zn finger	373..391	CDD:275368	5/17 (29%)
		zf-C2H2_6	425..450	CDD:290623	7/25 (28%)
		C2H2 Zn finger	427..447	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910