DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CTCF and ZNF581

DIOPT Version :9

Sequence 1:NP_648109.1 Gene:CTCF / 38817 FlyBaseID:FBgn0035769 Length:818 Species:Drosophila melanogaster
Sequence 2:NP_057619.1 Gene:ZNF581 / 51545 HGNCID:25017 Length:197 Species:Homo sapiens


Alignment Length:257 Identity:64/257 - (24%)
Similarity:91/257 - (35%) Gaps:79/257 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   174 PPPALVVKVPAPRGRPRKNPVIPKPEPMDLERELEELVDEPDISSMVTELSDYTVDEAAVEAATA 238
            |.|.....|....|.||:....|:|.|       ...:..|..||                    
Human     9 PQPLAFSSVETMEGPPRRTCRSPEPGP-------SSSIGSPQASS-------------------- 46

  Fly   239 TLTPNEAEVYEFEDNATTEDENADKKDVDF-VLSNKEVKLKTASSTSQNSNASGHK--YSCPHCP 300
               |.....|..          .|.:.|.: ||.::|.:.:..:     |.|.|.|  ||||.|.
Human    47 ---PPRPNHYLL----------IDTQGVPYTVLVDEESQREPGA-----SGAPGQKKCYSCPVCS 93

  Fly   301 YTASKKFLITRHSRSHDVEPSFKCSICERSFRSNVGLQNHINTHM--GNKPHKCKLCESAFTTSG 363
            ........:.|||.:|.....|:|.||.::|:....|..|.:.|:  |.:||.|.||...|..:|
Human    94 RVFEYMSYLQRHSITHSEVKPFECDICGKAFKRASHLARHHSIHLAGGGRPHGCPLCPRRFRDAG 158

  Fly   364 ELVRHTRYKHTKEKPHKCTECTYASVELTKLRRHMTCHTGERPYQCPHCTYASQDMFKLKRH 425
            ||.:|:|                             .|:||||:|||||.....:...|::|
Human   159 ELAQHSR-----------------------------VHSGERPFQCPHCPRRFMEQNTLQKH 191

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CTCFNP_648109.1 23ISL <116..206 CDD:293226 9/31 (29%)
C2H2 Zn finger 296..316 CDD:275368 6/19 (32%)
COG5048 321..>621 CDD:227381 32/107 (30%)
zf-C2H2 322..344 CDD:278523 7/21 (33%)
C2H2 Zn finger 324..344 CDD:275368 6/19 (32%)
zf-H2C2_2 337..361 CDD:290200 10/25 (40%)
C2H2 Zn finger 352..373 CDD:275368 9/20 (45%)
C2H2 Zn finger 381..401 CDD:275368 0/19 (0%)
zf-H2C2_2 394..415 CDD:290200 10/20 (50%)
C2H2 Zn finger 409..429 CDD:275368 6/17 (35%)
zf-H2C2_2 422..446 CDD:290200 2/4 (50%)
C2H2 Zn finger 437..457 CDD:275368
C2H2 Zn finger 467..485 CDD:275368
C2H2 Zn finger 496..516 CDD:275370
C2H2 Zn finger 524..544 CDD:275368
zf-H2C2_2 536..561 CDD:290200
C2H2 Zn finger 552..573 CDD:275368
zf-C2H2 587..609 CDD:278523
C2H2 Zn finger 589..609 CDD:275368
ZNF581NP_057619.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..52 13/72 (18%)
C2H2 Zn finger 89..109 CDD:275368 6/19 (32%)
zf-H2C2_2 101..126 CDD:404364 9/24 (38%)
C2H2 Zn finger 117..137 CDD:275368 6/19 (32%)
C2H2 Zn finger 147..167 CDD:275368 9/48 (19%)
C2H2 Zn finger 175..193 CDD:275368 6/17 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24390
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.100

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