DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CTCF and Zfp202

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_001102760.1	Gene:	Zfp202 / 500981	RGDID:	1562294	Length:	643	Species:	Rattus norvegicus

Alignment Length:	650	Identity:	147/650 - (22%)
Similarity:	240/650 - (36%)	Gaps:	165/650 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RTKKDEDPEDLQTFLNNFHKE-----------IEGNSDEKVVNTILEAISAEAIDLDENGAEAGG 57
            |.::.|..|:..|.:....|:           ::|.          |.:|.|.:.|   |.|...
  Rat   109 RGQRPESGEEAVTLVEGLQKQPRRPRRWVTVHVQGQ----------EVLSEETLHL---GVEPES 160

  Fly    58 S----KPMEEAEADLDHAEEAEEEEEDDEDKYFIDDEGNCYIKTTPKKQKELQKKLKQAAAKP-- 116
            |    :|.:...|:..|.|.....:....::..:..||    :..|..:.|:  .:.|.|..|
  Rat   161 SNEQQEPTQTLTAEQPHEEALRSTDLGTLEQESLQHEG----ERLPLLESEV--PVSQHADLPTE 219

  Fly   117 -GKATRSVVSTATNKSINLRPAKSTPKATTSKPPPEPKAISVRPARAAAAKAKQSAMPPPP---- 176
             |.....:|:..|..|..|                    ::.:......::.:.|.:.|..
  Rat   220 QGSGHPEMVALLTALSQGL--------------------VTFKDVALCFSQDQWSDLDPTQKEFY 264

  Fly   177 ---------ALVVKVPAPRGRPRKNPVIPKPEPMDLERELEELVDEPDISSMVTELSDYTVDEAA 232
                     .:||.:..|         ||:             :|:|   |.:.|      :|..
  Rat   265 GEYVLEEDCGIVVSLSFP---------IPR-------------LDDP---SQIRE------EEPQ 298

  Fly   233 VEAATATLTPNEAEVYEFE---DNATTEDENADKKDVD-FVLSNKEV------KLKTASSTSQNS 287
            |.....:..|.|.|:..|.   |.:..|:|..:::|.: .:|:|.|:      ::....:||:.:
  Rat   299 VPGVHESQEPAEPEILSFTYTGDMSEAEEECVEQQDTNKSILANTEIHQTPDWEIVIEDNTSRLN 363

  Fly   288 NASGHKYSCPHCPYTASKKFLITRHS---RSHDVEPSFKCSICERSFRSNVGLQNHINTHMGNKP 349
            ...|...|..: .:|..:|.:.. ||   |.|      .|.:|.:||..|..|..|:.||.|.||
  Rat   364 ERFGTNVSKVN-SFTNIRKTMPV-HSQSGRQH------HCPLCAKSFTCNSHLIRHLRTHTGEKP 420

  Fly   350 HKCKLCESAFTTSGELVRHTRYKHTKEKPHKCTECTYASVELTKLRRHMTCHTGERPYQCPHCTY 414
            :||..|..::|.|..|.||.:. |....|||... ...:|:.::::...|... |:||.|..|..
  Rat   421 YKCMECGKSYTRSSHLARHQKV-HKVNTPHKHPP-NRKTVDASQVQSEATTRV-EKPYTCDDCGK 482

  Fly   415 ASQDMFKLKRHMVIHTGEKKYQCDICKSRFTQSNSLKAHKLIHSVVDKPVFQCNYCPTTCGRKAD 479
            ..:....|.||...|||||.:.|.||...|:|.:.|..|:.||                .|.|
  Rat   483 HFRWTSDLVRHQRTHTGEKPFFCTICGKSFSQKSVLTTHQRIH----------------VGGK-- 529

  Fly   480 LRVHIKHMHTSDVPMTCRRCGQQLPDRYQYKLHVKSHEGEKCYSCKLCSYASVTQRHLASHMLIH 544
                         |.||..||:...::.||..|.|:|..|:.:.|..|..:.......|.|:..|
  Rat   530 -------------PYTCANCGENFSEQKQYLAHRKTHVSEENHLCSECGRSFNHSAAFAKHLKGH 581

  Fly   545 LDEKPFHCDQCPQAFRQRQLLRRHMNLVHNEEYQPPEPREKLHKCPSCPREFTHKGNLMRHMETH 609
            ...:...||:|.::|.:|..|.||         |.....||...|.:|.:.|:...:|:||...|
  Rat   582 ASVRNCRCDECGKSFSRRDHLVRH---------QRTHTGEKPFTCATCGKSFSRGYHLIRHQRIH 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226	13/105 (12%)
		C2H2 Zn finger	296..316	CDD:275368	5/22 (23%)
		COG5048	321..>621	CDD:227381	83/288 (29%)
		zf-C2H2	322..344	CDD:278523	7/21 (33%)
		C2H2 Zn finger	324..344	CDD:275368	7/19 (37%)
		zf-H2C2_2	337..361	CDD:290200	10/23 (43%)
		C2H2 Zn finger	352..373	CDD:275368	7/20 (35%)
		C2H2 Zn finger	381..401	CDD:275368	2/19 (11%)
		zf-H2C2_2	394..415	CDD:290200	6/20 (30%)
		C2H2 Zn finger	409..429	CDD:275368	5/19 (26%)
		zf-H2C2_2	422..446	CDD:290200	12/23 (52%)
		C2H2 Zn finger	437..457	CDD:275368	7/19 (37%)
		C2H2 Zn finger	467..485	CDD:275368	2/17 (12%)
		C2H2 Zn finger	496..516	CDD:275370	7/19 (37%)
		C2H2 Zn finger	524..544	CDD:275368	4/19 (21%)
		zf-H2C2_2	536..561	CDD:290200	7/24 (29%)
		C2H2 Zn finger	552..573	CDD:275368	8/20 (40%)
		zf-C2H2	587..609	CDD:278523	6/21 (29%)
		C2H2 Zn finger	589..609	CDD:275368	6/19 (32%)
Zfp202	NP_001102760.1	SCAN	45..155	CDD:128708	10/58 (17%)
		KRAB	239..299	CDD:214630	12/90 (13%)
		COG5048	<334..626	CDD:227381	94/342 (27%)
		C2H2 Zn finger	395..415	CDD:275368	7/19 (37%)
		C2H2 Zn finger	423..443	CDD:275368	7/20 (35%)
		C2H2 Zn finger	477..497	CDD:275368	5/19 (26%)
		C2H2 Zn finger	505..525	CDD:275368	7/19 (37%)
		C2H2 Zn finger	533..553	CDD:275368	7/19 (37%)
		C2H2 Zn finger	561..581	CDD:275368	4/19 (21%)
		C2H2 Zn finger	589..609	CDD:275368	9/28 (32%)
		C2H2 Zn finger	617..637	CDD:275368	6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000