DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CTCF and Zfp879

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_001128072.1	Gene:	Zfp879 / 497896	RGDID:	1563273	Length:	555	Species:	Rattus norvegicus

Alignment Length:	553	Identity:	155/553 - (28%)
Similarity:	229/553 - (41%)	Gaps:	84/553 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 VSTATNKSINLRPAKST-----------PKATTSKPPPEPKAISVRPARAAAAKAKQSAMPPPPA 177
            ||.:.::.::|.||:.|           ..|:.....|:||.||  ....|..:..:|.|.....
  Rat    21 VSFSQDEWLHLDPAQRTLYREVMLENYSNLASLGILSPKPKVIS--QLEQADFQMVESGMFQGVY 83

  Fly   178 LVVK-VPAPRGRPRKNPVIPKPEPMD------------LERELEELVDEPD-----ISSMVTELS 224
            |..| :..||...::|..:.|.:.:|            .|.:|||   :|.     .|.|:..|.
  Rat    84 LGWKSLFEPRVSKKENKEVLKHQRVDDLFGFLLGKPCVNEEQLEE---QPGYRKNLFSEMLLFLR 145

  Fly   225 DYTVDEAAVEAATATLTPNEAEVYEFEDNATTEDENADKKDVDFVLSNKEVK--------LKTAS 281
            .....|...........|.:..|........:...:...:.:.|...:|..|        |.::|
  Rat   146 RDCTHERGFPGIELVRNPRKTRVVSEGRKPRSPQYSILFRQLGFNAVHKLYKCNICGKGFLHSSS 210

  Fly   282 STSQNSNASGHK-YSCPHC---------------------PYTAS---KKFLITR----HSRSHD 317
            .:......:|.| |.|..|                     ||..|   |.|..|.    |.|.|.
  Rat   211 LSKHQRIHTGEKLYQCKECRKAFSQSSSLTQHLRVHTGEKPYVCSECGKAFSFTTSLIGHQRMHT 275

  Fly   318 VEPSFKCSICERSFRSNVGLQNHINTHMGNKPHKCKLCESAFTTSGELVRHTRYKHTKEKPHKCT 382
            .|..::|..|.::|:.:..|.||...|.|.||:.|.:|..||:....|::|.|. ||.|||::|:
  Rat   276 GERPYRCKECGKTFKGSSSLNNHQRIHTGEKPYTCSVCGRAFSQCSSLIQHQRI-HTGEKPYECS 339

  Fly   383 ECTYASVELTKLRRHMTCHTGERPYQCPHCTYASQDMFKLKRHMVIHTGEKKYQCDICKSRFTQS 447
            :|..|...:::|.||...||||:|:.|..|.........|..|..||||||.|.|..|...|:||
  Rat   340 QCGKAFTSISRLSRHHRIHTGEKPFHCNVCGKVFSYHSALIIHQRIHTGEKPYACKECGKAFSQS 404

  Fly   448 NSLKAHKLIHSVVDKPVFQCNYCPTTCGRKADLRVHIKHMHTSDVPMTCRRCGQQLPDRYQYKLH 512
            ::|..|:.||: .:|| ::|:.|.......:.|.:| ..:||.:.|..|:.||:..........|
  Rat   405 SALIQHQRIHT-GEKP-YKCDECGKAFSWISRLNIH-HRIHTGEKPYHCKECGKAFSSHSAVNTH 466

  Fly   513 VKSHEGEKCYSCKLCSYASVTQRHLASHMLIHLDEKPFHCDQCPQAFRQRQLLRRHMNLVHNEEY 577
            .|.|.|||.|.|..|..|......|..|..||..||||:|..|.:||||...|..|.. :|.
  Rat   467 RKIHTGEKPYKCSDCEKAFNQSSALIQHQRIHTGEKPFNCKVCGKAFRQSSSLMTHTR-IHT--- 527

  Fly   578 QPPEPREKLHKCPSCPREFTHKGNLMRHMETHD 610
                 .||.:||.:|.:.|:...:|..|.:||:
  Rat   528 -----GEKPYKCKTCGKAFSQSSSLANHQKTHN 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226	23/105 (22%)
		C2H2 Zn finger	296..316	CDD:275368	10/47 (21%)
		COG5048	321..>621	CDD:227381	102/290 (35%)
		zf-C2H2	322..344	CDD:278523	6/21 (29%)
		C2H2 Zn finger	324..344	CDD:275368	6/19 (32%)
		zf-H2C2_2	337..361	CDD:290200	11/23 (48%)
		C2H2 Zn finger	352..373	CDD:275368	7/20 (35%)
		C2H2 Zn finger	381..401	CDD:275368	6/19 (32%)
		zf-H2C2_2	394..415	CDD:290200	10/20 (50%)
		C2H2 Zn finger	409..429	CDD:275368	4/19 (21%)
		zf-H2C2_2	422..446	CDD:290200	12/23 (52%)
		C2H2 Zn finger	437..457	CDD:275368	7/19 (37%)
		C2H2 Zn finger	467..485	CDD:275368	4/17 (24%)
		C2H2 Zn finger	496..516	CDD:275370	5/19 (26%)
		C2H2 Zn finger	524..544	CDD:275368	5/19 (26%)
		zf-H2C2_2	536..561	CDD:290200	12/24 (50%)
		C2H2 Zn finger	552..573	CDD:275368	8/20 (40%)
		zf-C2H2	587..609	CDD:278523	6/21 (29%)
		C2H2 Zn finger	589..609	CDD:275368	5/19 (26%)
Zfp879	NP_001128072.1	KRAB	14..72	CDD:214630	13/52 (25%)
		KRAB	14..53	CDD:279668	7/31 (23%)
		COG5048	194..554	CDD:227381	119/372 (32%)
		C2H2 Zn finger	198..218	CDD:275368	2/19 (11%)
		zf-H2C2_2	210..235	CDD:290200	6/24 (25%)
		C2H2 Zn finger	226..246	CDD:275368	2/19 (11%)
		zf-H2C2_2	238..262	CDD:290200	4/23 (17%)
		C2H2 Zn finger	254..274	CDD:275368	6/19 (32%)
		zf-H2C2_2	270..290	CDD:290200	6/19 (32%)
		C2H2 Zn finger	282..302	CDD:275368	6/19 (32%)
		zf-H2C2_2	294..319	CDD:290200	11/24 (46%)
		C2H2 Zn finger	310..330	CDD:275368	7/20 (35%)
		zf-H2C2_2	322..347	CDD:290200	11/25 (44%)
		C2H2 Zn finger	338..358	CDD:275368	6/19 (32%)
		zf-H2C2_2	351..375	CDD:290200	10/23 (43%)
		C2H2 Zn finger	366..386	CDD:275368	4/19 (21%)
		zf-H2C2_2	378..403	CDD:290200	12/24 (50%)
		C2H2 Zn finger	394..414	CDD:275368	7/19 (37%)
		zf-H2C2_2	406..430	CDD:290200	8/25 (32%)
		C2H2 Zn finger	422..442	CDD:275368	4/20 (20%)
		zf-H2C2_2	435..459	CDD:290200	8/24 (33%)
		C2H2 Zn finger	450..470	CDD:275368	5/19 (26%)
		zf-H2C2_2	462..487	CDD:290200	10/24 (42%)
		C2H2 Zn finger	478..498	CDD:275368	5/19 (26%)
		zf-H2C2_2	490..515	CDD:290200	12/24 (50%)
		C2H2 Zn finger	506..526	CDD:275368	8/20 (40%)
		zf-H2C2_2	518..543	CDD:290200	9/33 (27%)
		C2H2 Zn finger	534..554	CDD:275368	5/19 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000