DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CTCF and CG31224

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_001287396.1	Gene:	CG31224 / 42237	FlyBaseID:	FBgn0051224	Length:	1784	Species:	Drosophila melanogaster

Alignment Length:	662	Identity:	145/662 - (21%)
Similarity:	242/662 - (36%)	Gaps:	162/662 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 AGGSKPMEEAEADLDHAEEAEEEEEDDEDKYFIDDEGNCY---IKTTPKKQKELQKKLKQAAAKP 116
            |.|....:|:..|:::: .:|....|...:||.:.....|   .:......::|..:|::.....
  Fly  1139 AKGEISEQESNCDIENS-WSESVYGDISQRYFRNQFSGGYHPDWRQDYYPAQDLSAQLREHKRFD 1202

  Fly   117 GKATRSVVSTATNKS-INLRPAKSTPKATTSKP--PPEPKAISVRPARAAAAKAKQSAMPPP--- 175
            ..|.....|:::.:| :...|..:|..|.||..  ...|.|.:.|.|..|||:|...|...|
  Fly  1203 FNAVDDEASSSSRRSHLTDLPTAATSSACTSSAMLAGPPIASTSRAAAEAAAEAAALAQRKPQRR 1267

  Fly   176 --------PALVVKVPAPRG---------RPRKNPVIPKPE----PMDLEREL------------ 207
                    .|:..|:.....         |..:..:..:|:    .:.|::::
  Fly  1268 KLYKCPHCEAIFEKLKERNAHMIGEHNYVRQNRRLICTQPQINTSMLTLQQQMIVQSGEVEDSKD 1332

  Fly   208 -------EELVDEPDI------SSMVTELSD---------------------YTVDEAAVEAATA 238
                   |:..::.|:      |.::.::.|                     ..:||.......|
  Fly  1333 GIVKIKQEQCQEKQDVEQMHDHSELLADVKDSELMGIGGDGDGDVDDDIKPPNQLDEKPTLPPLA 1397

  Fly   239 TLTP--------------NEAEVYEFEDNATTEDENADKKDV--------DFVLSNKEVKLKTAS 281
            ..||              ||:::.:..:|.:..::.|.:|.:        ||    ..|||..|.
  Fly  1398 MTTPAAKLAALYRMLIAYNESKLGQERNNLSELEQKAMEKSIFLCYVCRTDF----PSVKLYDAH 1458

  Fly   282 STSQNSNASGHKYSCPHCPYTASKKFL----ITRHSRSHDVEPSFKCSICERSFRSNVGLQNHIN 342
            .|.       |...|    :|..|||.    .:.|.:.|.....|.|.:|::.|.....|..|:.
  Fly  1459 LTE-------HPAEC----FTCGKKFYRWKNFSLHLKRHLGWKEFGCYVCDKKFVVRSALVEHMR 1512

  Fly   343 THMGNKPHKCKLCESAFTTSGELVRHTRYKHTKE------------------------------K 377
            .|.|..|.|||:|...|.....|.:| |.:|||.                              |
  Fly  1513 MHTGQTPLKCKICGKKFKRYSNLTQH-RKRHTKMMVRKKEYVCHCGEVLPSKARFLWHKETHDLK 1576

  Fly   378 PHKCTECTYASVELTKLRRHM-TCHTGE----RPYQCPHCTYASQDMF---KLKRHMVIHTGEKK 434
            |..|..|....|....||||: ..|:.:    .|.:||.|    :.:|   .:|.||..|:.|.:
  Fly  1577 PKCCPYCCDRFVHANSLRRHIRLAHSDKFDYAEPMECPMC----KQIFAKTSIKAHMATHSTEPQ 1637

  Fly   435 YQCDICKSRFTQSNSLKAHKLIHSVVDKPVFQCNYCPTTCGRKADLRVHIKHMHTSDVPMTCRRC 499
            |.|.||...|:...:||.|..:|:......|:|.|||....|:.|.:.|| :.|....|.||..|
  Fly  1638 YDCAICSKSFSTKWNLKIHSWVHANRTAKPFKCEYCPKAFVRELDFKNHI-NAHKQIKPYTCEYC 1701

  Fly   500 GQQLPDRYQYKLHVKSHEGEKCYSCKLCSYASVTQRHLASHMLIHLDEKPFHCDQCPQAFRQRQL 564
            |.:...:|.|..|.:.|.|.|.::|..|..:.....:|..|..:|..|:||.|..|.::...:..
  Fly  1702 GCKFIRKYNYMRHRREHHGTKKFTCDQCDKSFHRHYYLIEHRRMHTGERPFTCTICGKSSTTKTN 1766

  Fly   565 LRRHMNLVHNEE 576
            ..:|:.:.|:.:
  Fly  1767 HNKHLKIHHSRD 1778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226	23/116 (20%)
		C2H2 Zn finger	296..316	CDD:275368	6/23 (26%)
		COG5048	321..>621	CDD:227381	82/294 (28%)
		zf-C2H2	322..344	CDD:278523	6/21 (29%)
		C2H2 Zn finger	324..344	CDD:275368	5/19 (26%)
		zf-H2C2_2	337..361	CDD:290200	10/23 (43%)
		C2H2 Zn finger	352..373	CDD:275368	7/20 (35%)
		C2H2 Zn finger	381..401	CDD:275368	7/20 (35%)
		zf-H2C2_2	394..415	CDD:290200	9/25 (36%)
		C2H2 Zn finger	409..429	CDD:275368	7/22 (32%)
		zf-H2C2_2	422..446	CDD:290200	10/23 (43%)
		C2H2 Zn finger	437..457	CDD:275368	7/19 (37%)
		C2H2 Zn finger	467..485	CDD:275368	7/17 (41%)
		C2H2 Zn finger	496..516	CDD:275370	6/19 (32%)
		C2H2 Zn finger	524..544	CDD:275368	4/19 (21%)
		zf-H2C2_2	536..561	CDD:290200	8/24 (33%)
		C2H2 Zn finger	552..573	CDD:275368	3/20 (15%)
		zf-C2H2	587..609	CDD:278523
		C2H2 Zn finger	589..609	CDD:275368
CG31224	NP_001287396.1	C2H2 Zn finger	1466..1486	CDD:275368	6/23 (26%)
		C2H2 Zn finger	1494..1514	CDD:275368	5/19 (26%)
		zf-H2C2_2	1506..1531	CDD:290200	10/24 (42%)
		C2H2 Zn finger	1522..1542	CDD:275368	7/20 (35%)
		PHA00733	1527..1623	CDD:177301	22/100 (22%)
		C2H2 Zn finger	1554..1573	CDD:275370	0/18 (0%)
		C2H2 Zn finger	1580..1599	CDD:275368	7/18 (39%)
		C2H2 Zn finger	1613..1632	CDD:275368	7/22 (32%)
		COG5048	<1637..1780	CDD:227381	42/143 (29%)
		C2H2 Zn finger	1640..1660	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1670..1690	CDD:275368	8/20 (40%)
		C2H2 Zn finger	1698..1718	CDD:275368	6/19 (32%)
		zf-H2C2_2	1710..1735	CDD:290200	7/24 (29%)
		C2H2 Zn finger	1726..1746	CDD:275368	4/19 (21%)
		zf-H2C2_2	1738..1763	CDD:290200	8/24 (33%)
		C2H2 Zn finger	1754..1774	CDD:275368	3/19 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	86	1.000	Inparanoid score	I3725
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.050