DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CTCF and ctcf

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_001001844.1	Gene:	ctcf / 415104	ZFINID:	ZDB-GENE-040624-5	Length:	798	Species:	Danio rerio

Alignment Length:	830	Identity:	256/830 - (30%)
Similarity:	380/830 - (45%)	Gaps:	131/830 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 IEGNSDEKVVNTILEAISAEAI-------DLDENGAEAGGSKPMEEAEADLDHAEEAEEE--EED 80
            :||...|.||....:|..|:..       :.:|.|||...:..:|:|:|:::...||:::  |..
Zfish     1 MEGGPTEAVVEDAGDAFKAKECKTYQRRREDEEVGAELLQAAVIEQAQAEVEPVVEAQQQLVESV 65

  Fly    81 DEDKYFIDDEGNCYIKTTPKKQKELQKKLKQAA-----AKPGKATRSVVSTA------TNKSINL 134
            ......:|   ...::|......:::.::.:||     |..|.|..:.|:|.      |.:.:|:
Zfish    66 VSVNSSVD---MMMMETLDPALLQMKTEVMEAAVGAPVAVAGAAHEATVTTVDDTQIITLQVVNM 127

  Fly   135 RPAK-STPKATTSKPPPEPKAISVRPARAAAAKAKQ------SAMPP--PPALVVKVPAPRG--- 187
            ...: ...:....:.|     :|..|..||..:..|      :|||.  .|.:...:|.|.|
Zfish   128 EEQQLGLGELQLVQVP-----VSAVPVTAATVEELQGTLVDATAMPKDGEPVICHTLPLPEGFQV 187

  Fly   188 ----------RPRKNPVIPKPEPMDLERELEELVDEPDISSMVTELSDYTVDEAAV-EAATATLT 241
                      ...::.:.|:.:....:.|.||:.:..:.....::..|||.....| :...:.|.
Zfish   188 VKVGANGEVETVEQDELQPQDDQPPHQEEEEEMAEPQNEDPAWSKDPDYTPPVKKVKKTKKSKLR 252

  Fly   242 PN-------EAEVYEFED---NATTEDENADKKDVDFVLSNKEVKLKTASSTSQNSNASGHKYSC 296
            .|       :..||:||:   .....:.||:|     |:.|    :|....|..........:.|
Zfish   253 YNTEGDKDMDVSVYDFEEEQQEGLLSEVNAEK-----VVGN----MKPPKPTKIKKKGVKKTFQC 308

  Fly   297 PHCPYTASKKFLITRHSRSHDVEPSFKCSICERSFRSNVGLQNHINTHMGNKPHKCKLCESAFTT 361
            ..|.||..::..:.||.:||..|...||.:|.|:||:...|:||:|||.|.:||||..|:.||.|
Zfish   309 ELCSYTCPRRSNLDRHMKSHTDERPHKCHLCGRAFRTVTLLRNHLNTHTGTRPHKCTDCDMAFVT 373

  Fly   362 SGELVRHTRYKHTKEKPHKCTECTYASVELTKLRRHMTCHTGERPYQCPHCTYASQDMFKLKRHM 426
            |||||||.|||||.|||.||:.|.|||||::||:||:..||||||:||..|:|||:|.:||||||
Zfish   374 SGELVRHRRYKHTHEKPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHM 438

  Fly   427 VIHTGEKKYQCDICKSRFTQSNSLKAHKLIHSVVDKPVFQCNYCPTTCGRKADLRVHIKHMHT-S 490
            ..|:|||.|:|.||.:|||||.::|.|.|.....:...|.|.:|.|...||:||.||::..|: .
Zfish   439 RTHSGEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPHCDTVIARKSDLGVHLRKQHSYI 503

  Fly   491 DVPMTCRRCGQQLPDRYQYKLHVKSHEGEKCYSCKLCSYASVTQRHLASHMLIHLDEKPFHCDQC 555
            :....||.|.....:||....|.|||:.||.:.|..|.||...:||:..|...|..|||:.|.||
Zfish   504 EQGRKCRYCDAVFHERYALIQHQKSHKNEKRFKCDQCDYACRQERHMVMHKRTHTGEKPYACSQC 568

  Fly   556 PQAFRQRQLLRRHMNLVHNEEYQPPEPREKLHKCPSCPREFTHKGNLMRHME--THDDSANARE- 617
            .:.|||:|||..|....|:..:.|..     ..|..|.:.||.:..:.||.|  |..|||:...
Zfish   569 EKTFRQKQLLDMHFRRYHDPNFVPTS-----FVCTKCGKTFTRRNTMARHAENCTGMDSADGENG 628

  Fly   618 ---KRRRLKLGRNVRLQKDGTVITLIKDQYVDMDRDQEENEEDDNPESYDLAEIEPENSEAEDAD 679
               ||.|....|.:|.:||              |.|.::::|...|   ||.:|: |..|.:..|
Zfish   629 TPPKRGRGGRKRKMRSRKD--------------DDDDDDSDEHGEP---DLDDID-EEDEDDLLD 675

  Fly   680 DD-------------VETIVSDPI-RQRIKP---APII-----INKQARLAASEKQPMIINQRLR 722
            :|             :......|| |:|.:|   ||.:     |.|....||      ||.....
Zfish   676 EDQMGLLDQAPPSVPIPAPAEPPIKRKRGRPPKNAPKVSPTKSITKTTTAAA------IIQVEDE 734

  Fly   723 SQRGTKTFHIKEEPDNSDFTVEWQGDDGEVMVVELVNGDEEVLVKHEPSA 772
            |....:...:|:||:.:|..|..|....|   ||.|..|.|.:....|.|
Zfish   735 STGAIENIIVKKEPEGTDAVVAAQPIIEE---VEAVEADVETVQLTVPEA 781

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226	20/117 (17%)
		C2H2 Zn finger	296..316	CDD:275368	6/19 (32%)
		COG5048	321..>621	CDD:227381	141/306 (46%)
		zf-C2H2	322..344	CDD:278523	10/21 (48%)
		C2H2 Zn finger	324..344	CDD:275368	9/19 (47%)
		zf-H2C2_2	337..361	CDD:290200	14/23 (61%)
		C2H2 Zn finger	352..373	CDD:275368	14/20 (70%)
		C2H2 Zn finger	381..401	CDD:275368	11/19 (58%)
		zf-H2C2_2	394..415	CDD:290200	12/20 (60%)
		C2H2 Zn finger	409..429	CDD:275368	12/19 (63%)
		zf-H2C2_2	422..446	CDD:290200	15/23 (65%)
		C2H2 Zn finger	437..457	CDD:275368	11/19 (58%)
		C2H2 Zn finger	467..485	CDD:275368	9/17 (53%)
		C2H2 Zn finger	496..516	CDD:275370	7/19 (37%)
		C2H2 Zn finger	524..544	CDD:275368	7/19 (37%)
		zf-H2C2_2	536..561	CDD:290200	10/24 (42%)
		C2H2 Zn finger	552..573	CDD:275368	10/20 (50%)
		zf-C2H2	587..609	CDD:278523	7/23 (30%)
		C2H2 Zn finger	589..609	CDD:275368	7/21 (33%)
ctcf	NP_001001844.1	COG5048	<305..468	CDD:227381	91/162 (56%)
		C2H2 Zn finger	308..328	CDD:275368	6/19 (32%)
		zf-H2C2_2	320..345	CDD:290200	10/24 (42%)
		C2H2 Zn finger	336..356	CDD:275368	9/19 (47%)
		zf-H2C2_2	349..373	CDD:290200	14/23 (61%)
		C2H2 Zn finger	364..387	CDD:275368	16/22 (73%)
		C2H2 Zn finger	393..413	CDD:275368	11/19 (58%)
		COG5048	<406..540	CDD:227381	61/133 (46%)
		zf-H2C2_2	406..427	CDD:290200	12/20 (60%)
		C2H2 Zn finger	421..441	CDD:275368	12/19 (63%)
		zf-H2C2_2	434..458	CDD:290200	15/23 (65%)
		C2H2 Zn finger	449..466	CDD:275368	9/16 (56%)
		DiS_P_DiS	<478..523	CDD:284224	15/44 (34%)
		C2H2 Zn finger	479..497	CDD:275368	9/17 (53%)
		C2H2 Zn finger	509..529	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		zf-H2C2_2	549..574	CDD:290200	10/24 (42%)
		C2H2 Zn finger	565..586	CDD:275368	10/20 (50%)
		C2H2 Zn finger	597..613	CDD:275368	4/15 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BAC7
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	328	1.000	Inparanoid score	I2442
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto40795
orthoMCL	1	0.900	-	-		OOG6_107263
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10659
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.750