DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CTCF and ZNF568

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_940941.2	Gene:	ZNF568 / 374900	HGNCID:	25392	Length:	644	Species:	Homo sapiens

Alignment Length:	360	Identity:	120/360 - (33%)
Similarity:	165/360 - (45%)	Gaps:	33/360 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   260 NADKKDVDFVLSNKEVKLKTASSTSQNSNASGHKYSCPHCPYTASKKFL----ITRHSRSHDVEP 320
            :|.:|..:.....|....|....|.|..:.....|.|..|    .|.|:    :.||.|.|..|.
Human   244 HAGEKPYECKECGKAFSRKENLITHQKIHTGEKPYKCNEC----GKAFIQMSNLIRHHRIHTGEK 304

  Fly   321 SFKCSICERSFRSNVGLQNHINTHMGNKPHKCKLCESAFTTSGELVRHTRYKHTKEKPHKCTECT 385
            .:.|..|.::|.....|..|...|.|.||::||.|..:|:....|:.|.:. ||.|||:.|.||.
Human   305 PYACKDCWKAFSQKSNLIEHERIHTGEKPYECKECGKSFSQKQNLIEHEKI-HTGEKPYACNECG 368

  Fly   386 YASVELTKLRRHMTCHTGERPYQCPHCTYASQDMFKLKRHMVIHTGEKKYQCDICKSRFTQSNSL 450
            .|...::.:..||..||||:||:|..|..|.........||..|||||.|.|..|...|:||:||
Human   369 RAFSRMSSVTLHMRSHTGEKPYKCNKCGKAFSQCSVFIIHMRSHTGEKPYVCSECGKAFSQSSSL 433

  Fly   451 KAHKLIHSVVDKPVFQCNYCPTTCGRKADLRVHIKHMHTSDVPMTCRRCGQQLPDRYQYKLHVKS 515
            ..|...|: .:|| ::|..|.....||.:|..|.| :||.:.|..|..||:..........|.:.
Human   434 TVHMRNHT-AEKP-YECKECGKAFSRKENLITHQK-IHTGEKPYECSECGKAFIQMSNLIRHQRI 495

  Fly   516 HEGEKCYSCKLCSYASVTQRHLASHMLIHLDEKPFHCDQCPQAFRQRQLLRRHMNLVHNEEYQPP 580
            |.|||.|:|.:|..|...:.:|..|..||..|||:||:||.:||.|||.|..|
Human   496 HTGEKPYACTVCGKAFSQKSNLTEHEKIHTGEKPYHCNQCGKAFSQRQNLLEH------------ 548

  Fly   581 EPREKLH------KCPSCPREFTHKGNLMRHMETH 609
               ||:|      ||..|.:.|:...:|..|:.:|
Human   549 ---EKIHTGEKPFKCNECGKAFSRISSLTLHVRSH 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226
		C2H2 Zn finger	296..316	CDD:275368	7/23 (30%)
		COG5048	321..>621	CDD:227381	104/295 (35%)
		zf-C2H2	322..344	CDD:278523	5/21 (24%)
		C2H2 Zn finger	324..344	CDD:275368	5/19 (26%)
		zf-H2C2_2	337..361	CDD:290200	10/23 (43%)
		C2H2 Zn finger	352..373	CDD:275368	6/20 (30%)
		C2H2 Zn finger	381..401	CDD:275368	6/19 (32%)
		zf-H2C2_2	394..415	CDD:290200	10/20 (50%)
		C2H2 Zn finger	409..429	CDD:275368	5/19 (26%)
		zf-H2C2_2	422..446	CDD:290200	11/23 (48%)
		C2H2 Zn finger	437..457	CDD:275368	8/19 (42%)
		C2H2 Zn finger	467..485	CDD:275368	6/17 (35%)
		C2H2 Zn finger	496..516	CDD:275370	4/19 (21%)
		C2H2 Zn finger	524..544	CDD:275368	5/19 (26%)
		zf-H2C2_2	536..561	CDD:290200	13/24 (54%)
		C2H2 Zn finger	552..573	CDD:275368	10/20 (50%)
		zf-C2H2	587..609	CDD:278523	7/27 (26%)
		C2H2 Zn finger	589..609	CDD:275368	5/19 (26%)
ZNF568	NP_940941.2	KRAB	48..102	CDD:214630
		KRAB	48..87	CDD:279668
		C2H2 Zn finger	224..244	CDD:275368	120/360 (33%)
		zf-H2C2_2	236..261	CDD:290200	3/16 (19%)
		COG5048	248..634	CDD:227381	119/356 (33%)
		C2H2 Zn finger	252..272	CDD:275368	4/19 (21%)
		zf-H2C2_2	264..289	CDD:290200	7/28 (25%)
		C2H2 Zn finger	280..300	CDD:275368	7/23 (30%)
		zf-H2C2_2	292..317	CDD:290200	8/24 (33%)
		C2H2 Zn finger	308..328	CDD:275368	5/19 (26%)
		zf-H2C2_2	320..345	CDD:290200	10/24 (42%)
		C2H2 Zn finger	336..356	CDD:275368	6/20 (30%)
		zf-H2C2_2	348..373	CDD:290200	11/25 (44%)
		C2H2 Zn finger	364..384	CDD:275368	6/19 (32%)
		zf-H2C2_2	380..401	CDD:290200	11/20 (55%)
		C2H2 Zn finger	392..412	CDD:275368	5/19 (26%)
		zf-H2C2_2	408..429	CDD:290200	11/20 (55%)
		C2H2 Zn finger	420..440	CDD:275368	8/19 (42%)
		zf-H2C2_2	432..457	CDD:290200	8/26 (31%)
		C2H2 Zn finger	448..468	CDD:275368	7/20 (35%)
		zf-H2C2_2	460..485	CDD:290200	9/25 (36%)
		C2H2 Zn finger	476..496	CDD:275368	4/19 (21%)
		zf-H2C2_2	488..513	CDD:290200	9/24 (38%)
		C2H2 Zn finger	504..524	CDD:275368	5/19 (26%)
		zf-H2C2_2	516..541	CDD:290200	13/24 (54%)
		C2H2 Zn finger	532..552	CDD:275368	12/34 (35%)
		zf-H2C2_2	544..569	CDD:290200	9/39 (23%)
		C2H2 Zn finger	560..580	CDD:275368	5/19 (26%)
		zf-H2C2_2	572..597	CDD:290200	3/9 (33%)
		C2H2 Zn finger	588..608	CDD:275368
		zf-H2C2_2	601..625	CDD:290200
		C2H2 Zn finger	616..636	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000