DRSC/TRiP Functional Genomics Resources

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Protein Alignment CTCF and CG12391

DIOPT Version :9

Sequence 1:NP_648109.1 Gene:CTCF / 38817 FlyBaseID:FBgn0035769 Length:818 Species:Drosophila melanogaster
Sequence 2:NP_610639.1 Gene:CG12391 / 36170 FlyBaseID:FBgn0033581 Length:587 Species:Drosophila melanogaster


Alignment Length:541 Identity:124/541 - (22%)
Similarity:192/541 - (35%) Gaps:163/541 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 KKDEDPEDLQTFL---NNFHKEIEGNSDEKVVNTILEAISAEAIDL----DENGAEAGGSKPMEE 63
            :||.|.|...|.|   ||...|.:|:          ||.:.:..|:    ||:|.|. |.:.:||
  Fly   128 EKDTDKEKKATHLHEDNNDDAEKDGD----------EADAEDEDDVEKPEDEDGTEE-GDEAIEE 181

  Fly    64 AEADLDHAEEAEEEEED------------------DEDKYFID------------DEGNCYIKTT 98
            .|..||..|:..||.|:                  ||.....|            ||..|.:.|:
  Fly   182 DEDALDEDEDPNEEVEEIEPDFETGTDAEGELITGDEPGDLADVPIRERKKEEPVDEDQCRVCTS 246

  Fly    99 PKKQKELQKKLKQAAAKPGKATRSVVSTATNKSINLRPAKSTPKATTSKPPPE-PKAISVR---- 158
            .::...|.|  ||..|.|......:.     .::::.|....|:...:|.... ..||.:|    
  Fly   247 KEELVCLFK--KQIDATPADMLLVIC-----PNVSILPKDFMPQFICTKCMGSLTIAIQLRKQLE 304

  Fly   159 ----PARAAAAKAKQSAMPPPPALVVKVPAPRGRPRKNPVIPKPEPMDLERELEELVDEPDISSM 219
                ..|...:::|.           ||..|||    ..||..| ..|...:.:||.||..:|  
  Fly   305 TTDQELRKRLSRSKN-----------KVRRPRG----YVVIDAP-VTDSSEDEDELDDEFKVS-- 351

  Fly   220 VTELSDYTVDEAAVEAATATLTPNEAEVYEFEDNATTEDENADKK-----------------DVD 267
                     |.|...:|.:             |:|.::|...:||                 |.|
  Fly   352 ---------DVAGTTSADS-------------DSADSDDSEKEKKKPGPRGRPRKKPLKRGTDSD 394

  Fly   268 FVLSNKEVKLKTASSTSQNSNASGHKYSCPHCPYTASKKFLITRHSRSHD-VEPSFKCSICERSF 331
            ...|:.:.|....|||     ||...:.||:|..|.|:|.....|.::|: :|.:  |.||.:.|
  Fly   395 GEPSSAQKKKYQPSST-----ASVGPFECPNCDLTFSRKQSYVLHRKTHERIEHA--CPICGKKF 452

  Fly   332 RSNVGLQNHINTHMGNKPH-KCKLCESAFTTSGELVRHTRYKHTKEK-PHKCTECTYASVELTKL 394
            :.....:.|:..|...:.| :|:||...|....||..|...:|.:.. .::|..|....:...:|
  Fly   453 KVEWAYKTHMQRHEQERAHFRCELCPKIFRLRAELKHHMAQRHDEHGFIYECKRCQRTFLTQQRL 517

  Fly   395 RRHMTCHTGERPYQCPHCTYASQDMFKLKRHMVIHTGEKKYQCDICKSRFTQSNSLK--AHKLIH 457
            :||          |...|....:|..::|..               :|||.|.:..|  .|...:
  Fly   518 QRH----------QAVGCQRHKEDSVRIKEE---------------QSRFKQESRSKDDRHHGNN 557

  Fly   458 SVVDKP-----VFQCNYCPTT 473
            |...:|     :|:....|||
  Fly   558 SSKRRPGEGRDLFKAVAPPTT 578

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CTCFNP_648109.1 23ISL <116..206 CDD:293226 18/98 (18%)
C2H2 Zn finger 296..316 CDD:275368 7/19 (37%)
COG5048 321..>621 CDD:227381 36/162 (22%)
zf-C2H2 322..344 CDD:278523 5/21 (24%)
C2H2 Zn finger 324..344 CDD:275368 5/19 (26%)
zf-H2C2_2 337..361 CDD:290200 7/24 (29%)
C2H2 Zn finger 352..373 CDD:275368 7/20 (35%)
C2H2 Zn finger 381..401 CDD:275368 5/19 (26%)
zf-H2C2_2 394..415 CDD:290200 5/20 (25%)
C2H2 Zn finger 409..429 CDD:275368 3/19 (16%)
zf-H2C2_2 422..446 CDD:290200 4/23 (17%)
C2H2 Zn finger 437..457 CDD:275368 6/21 (29%)
C2H2 Zn finger 467..485 CDD:275368 3/7 (43%)
C2H2 Zn finger 496..516 CDD:275370
C2H2 Zn finger 524..544 CDD:275368
zf-H2C2_2 536..561 CDD:290200
C2H2 Zn finger 552..573 CDD:275368
zf-C2H2 587..609 CDD:278523
C2H2 Zn finger 589..609 CDD:275368
CG12391NP_610639.1 zf-AD 240..313 CDD:285071 15/79 (19%)
zf-C2H2 416..438 CDD:278523 7/21 (33%)
C2H2 Zn finger 418..438 CDD:275368 7/19 (37%)
zf-C2H2 443..465 CDD:278523 5/23 (22%)
C2H2 Zn finger 445..465 CDD:275368 5/19 (26%)
C2H2 Zn finger 474..491 CDD:275368 6/16 (38%)
C2H2 Zn finger 504..521 CDD:275368 5/26 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR24390
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
11.100

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