DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CTCF and ZBTB41

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_919290.2	Gene:	ZBTB41 / 360023	HGNCID:	24819	Length:	909	Species:	Homo sapiens

Alignment Length:	655	Identity:	152/655 - (23%)
Similarity:	253/655 - (38%)	Gaps:	135/655 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 RPRKNPVIPKPEPMDLERELEELVDEPDISSMVTELSD----------YTVDEAAVEAATATLTP 242
            |.||.|| ...:..|.|:|..:..|..:..:...|.||          |..:|..:|...:....
Human   255 RNRKCPV-KFDDTSDDEQESGDGSDNLNQENFDKEKSDRNDSEDPGSEYNAEEDELEEEMSDEYS 318

  Fly   243 NEAEVYEFEDNATTEDE-------NADKKDVDFVLSNKEVKL--------------KTASST--- 283
            :..|..|.:.|...|:.       |..:.....|:.|...|:              |..|.|
Human   319 DIEEQSEKDHNDAEEEPEAGDSVGNVHEGLTPVVIQNSNKKILQCPKCDKTFDRIGKYESHTRVH 383

  Fly   284 ---------------SQNSNASGHK-------------YSCPHC-PYTASKKFLITRHSRSH--- 316
                           |..||.:.|:             :.||:| ...||||.|.....|.|
Human   384 TGEKPFECDICHQRYSTKSNLTVHRKKHSNETEFHKKEHKCPYCNKLHASKKTLAKHVKRFHPEN 448

  Fly   317 ---------DVEPSFKCSICERSFRSNVGLQNHINTHMGNKPHKCKLCES--------------- 357
                     ....|:||.||::||.....|:.|:..|..:||.||..||.
Human   449 AQEFISIKKTKSESWKCDICKKSFTRRPHLEEHMILHSQDKPFKCTYCEEHFKSRFARLKHQEKF 513

  Fly   358 ------------AFTTSGELVRHTRYKHTKEKPHKCTECTYASVELTKLRRHMTCHTGERPYQCP 410
                        .|..:|.|.||....|..::...|..|..:..|.|.|:.|:..|:||:|:.|.
Human   514 HLGPFPCDICGRQFNDTGNLKRHIECTHGGKRKWTCFICGKSVRERTTLKEHLRIHSGEKPHLCS 578

  Fly   411 HCTYASQDMFKLKRHMVIHTGEKKYQCDICKSRFTQSNSLKAHKLIHSVVDKPVFQCNYCPTTCG 475
            .|..:.:.....:.|:.:|..:|:|:||.|...|.:.:.|..||.|||  .:...||..|....|
Human   579 ICGQSFRHGSSYRLHLRVHHDDKRYECDECGKTFIRHDHLTKHKKIHS--GEKAHQCEECGKCFG 641

  Fly   476 RKADLRVHIKHMHTSDVPM--------TCRRCGQQLPDRYQYKLHVKSHEGEKCYSCKLCSYASV 532
            |:..|.||.|.:|..:...        .|..|.:....:...::|.::|.|||.|.|::|:.:..
Human   642 RRDHLTVHYKSVHLGEKVWQKYKATFHQCDVCKKIFKGKSSLEMHFRTHSGEKPYKCQICNQSFR 706

  Fly   533 TQRHLASHMLIHLDEKPFHCDQCPQAFRQRQLLRRHMNLVHNEEYQPPEP----REKLHKCPSCP 593
            .::.|..|::||.|.:||:|..|...|:::..|:.|::.|| |...|.:|    .|||   .|.|
Human   707 IKKTLTKHLVIHSDARPFNCQHCNATFKRKDKLKYHIDHVH-EIKSPDDPLSTSEEKL---VSLP 767

  Fly   594 REFTHKGNLMR-HMETHDDSANAREKRRRLKLGRNVRLQKDGTVITLIKDQYVDMDRDQEENEED 657
            .|::....:.: ..:.:.|.....:...:..| :||..:. ...:||:..|..|...|...:...
Human   768 VEYSSDDKIFQTETKQYMDQPKVYQSEAKTML-QNVSAEV-CVPVTLVPVQMPDTPSDLVRHTTT 830

  Fly   658 DNPESYDLAEIEPENSEAEDADDDVETIVSDPIRQRIKPAPIIINKQARLAASEKQPMIINQRLR 722
            ..|.|:::...:|::::...|.|     ::...:..:.|.|      |.:....:...:::.|.:
Human   831 LPPSSHEILSPQPQSTDYPRAAD-----LAFLEKYTLTPQP------ANIVHPVRPEQMLDPREQ 884

  Fly   723 SQRGT 727
            |..||
Human   885 SYLGT 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226	7/17 (41%)
		C2H2 Zn finger	296..316	CDD:275368	9/20 (45%)
		COG5048	321..>621	CDD:227381	92/339 (27%)
		zf-C2H2	322..344	CDD:278523	8/21 (38%)
		C2H2 Zn finger	324..344	CDD:275368	7/19 (37%)
		zf-H2C2_2	337..361	CDD:290200	10/50 (20%)
		C2H2 Zn finger	352..373	CDD:275368	8/47 (17%)
		C2H2 Zn finger	381..401	CDD:275368	6/19 (32%)
		zf-H2C2_2	394..415	CDD:290200	8/20 (40%)
		C2H2 Zn finger	409..429	CDD:275368	3/19 (16%)
		zf-H2C2_2	422..446	CDD:290200	8/23 (35%)
		C2H2 Zn finger	437..457	CDD:275368	7/19 (37%)
		C2H2 Zn finger	467..485	CDD:275368	7/17 (41%)
		C2H2 Zn finger	496..516	CDD:275370	3/19 (16%)
		C2H2 Zn finger	524..544	CDD:275368	4/19 (21%)
		zf-H2C2_2	536..561	CDD:290200	10/24 (42%)
		C2H2 Zn finger	552..573	CDD:275368	5/20 (25%)
		zf-C2H2	587..609	CDD:278523	3/22 (14%)
		C2H2 Zn finger	589..609	CDD:275368	3/20 (15%)
ZBTB41	NP_919290.2	BTB_POZ_ZBTB41	66..179	CDD:349535
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	252..344		19/89 (21%)
		C2H2 Zn finger	363..383	CDD:275368	3/19 (16%)
		C2H2 Zn finger	391..411	CDD:275368	4/19 (21%)
		C2H2 Zn finger	424..442	CDD:275368	8/17 (47%)
		C2H2 Zn finger	465..485	CDD:275368	7/19 (37%)
		C2H2 Zn finger	493..510	CDD:275368	3/16 (19%)
		C2H2 Zn finger	520..541	CDD:275368	5/20 (25%)
		C2H2 Zn finger	549..569	CDD:275368	6/19 (32%)
		C2H2 Zn finger	577..597	CDD:275368	3/19 (16%)
		zf-C2H2	603..625	CDD:395048	8/21 (38%)
		C2H2 Zn finger	605..625	CDD:275368	7/19 (37%)
		C2H2 Zn finger	633..651	CDD:275368	7/17 (41%)
		C2H2 Zn finger	670..687	CDD:275368	2/16 (13%)
		C2H2 Zn finger	698..718	CDD:275368	4/19 (21%)
		C2H2 Zn finger	726..743	CDD:275368	4/16 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910