DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CTCF and Kr-h1

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_477466.1	Gene:	Kr-h1 / 33861	FlyBaseID:	FBgn0266450	Length:	845	Species:	Drosophila melanogaster

Alignment Length:	764	Identity:	160/764 - (20%)
Similarity:	252/764 - (32%)	Gaps:	243/764 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 SKPPPEPKAISVRPARAAAA-------------KAKQSAMP------PPPALVVKVPAPRGRPRK 191
            ||.|.:..|:...||:.:|.             |.:||:..      |||..........|.|
  Fly    33 SKSPAKAVAVKKSPAKDSATTKMVYYSANQLLIKTEQSSQAQFCLQVPPPLTATTTSVGLGVP-- 95

  Fly   192 NPVIPKPEPMDLERELEELVDEPDISSMVTELSDYTVDEAA--VEAATATLTPNEAEVYEFEDNA 254
                    |...::|..||:..|....|..:|.|....|..  |....|.....:.:..:..::.
  Fly    96 --------PSGGQQEHFELLQTPQQRQMQLQLQDQHQQEQQQFVSYQLAIQQHQKQQQQQQHESI 152

  Fly   255 TTEDENADKKDVDFVLSNKEVKLK-------TASSTSQ--NSNASGHKYSCPHCPYTASKKFLIT 310
            |.....|       ..|.:.:|.:       :|:..||  ..:||..::.|..|..|...|...|
  Fly   153 TNAAPTA-------APSAQRIKTEPVGGFPASAAVVSQVRKPSASKPQFKCDQCGMTFGSKSAHT 210

  Fly   311 RHSRSHD----------------------------------------VEP---------SFKCSI 326
            .|::||.                                        ::|         .::|::
  Fly   211 SHTKSHSKNQDLSLNGASGAGVAAPVSTAAIELNDAGLPVGIPKSPTIKPLANVAAGADPYQCNV 275

  Fly   327 CERSFRSNVGLQNHINTHMGNKPHKCKLCESAFTTSGELVRHTRYKHTKEKPHKCTECTYASVEL 391
            |:::|.....|..|..||.|.:|.:|:.|...|:....|..|.|. ||||:|:||..|..|....
  Fly   276 CQKTFAVPARLIRHYRTHTGERPFECEFCHKLFSVKENLQVHRRI-HTKERPYKCDVCGRAFEHS 339

  Fly   392 TKLRRHMTCHTGERPYQCPHCTYASQDMFKLKRHMVIHTGEKKYQCDI--CKSRFTQSNSLKAHK 454
            .||.|||..||||||::|..|........:|..||..|||||.|:|..  |...||.|..||.|
  Fly   340 GKLHRHMRIHTGERPHKCSVCEKTFIQSGQLVIHMRTHTGEKPYKCPEPGCGKGFTCSKQLKVH- 403

  Fly   455 LIHSVVDKPVFQCNYCPTTCGRKADLRVHIKHMHTSDVPMTCRRCGQQLPDRYQYKLHVKSHEGE 519
                                          ...||.:.|..|..|.:.....:..|||...|.|.
  Fly   404 ------------------------------SRTHTGEKPYHCDICFRDFGYNHVLKLHRVQHYGS 438

  Fly   520 KCYSCKLCSYASVTQRHLASHMLIHLDEKPFHCDQCPQAFRQ----------------RQLLRRH 568
            |||.|.:|......::.:.:|:..|.:|.|  .|:...|...                :.:....
  Fly   439 KCYKCTICDETFKNKKEMEAHIKGHANEVP--DDEAEAAAASAAASTSAGSSAGSPSLQGVSSNS 501

  Fly   569 MNLVHNEEYQPP---EPRE----KLHK-----------CPSCPREFTHKGNLMRHMETHDDSANA 615
            .:..|:....||   :||:    ::.|           .|..|...:         .|:..||::
  Fly   502 ESSNHSPPSSPPATKKPRQARQPRVSKTVAATLSIPTSSPLSPSSLS---------STYSPSASS 557

  Fly   616 R-----EKRRRLKLGRNVRLQKDGTVITLIKDQYVDMDRDQEENEEDDNPESYDLAEIE---PEN 672
            .     .....|.    |:::.|    .|.:|..|...:.......|:.|....:.:::   ||:
  Fly   558 MASPPPTSAHYLP----VQMEAD----ALSRDSGVSSAQPAHSTYADEEPTDLSMQQVQGQLPES 614

  Fly   673 SEAEDADDDVETIVSDPIRQRIKPAP--IIINKQARLAASEKQPMIINQRLRSQRGTKTFHIKEE 735
            :        |:...:.|....::|.|  :.||.....|||                     |...
  Fly   615 T--------VDYYQAPPSLLELQPQPAGLTINPALLEAAS---------------------IARR 650

  Fly   736 PDNSDFTVE--------WQGDDGEVMVVELVNG------DEEVLVKHEP 770
            .|::|..|:        ||       :::|..|      .|:....|:|
  Fly   651 HDDNDDQVQDEDVHAAAWQ-------MMQLCRGHGSLPPTEQPAPSHQP 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226	16/78 (21%)
		C2H2 Zn finger	296..316	CDD:275368	6/19 (32%)
		COG5048	321..>621	CDD:227381	86/340 (25%)
		zf-C2H2	322..344	CDD:278523	5/21 (24%)
		C2H2 Zn finger	324..344	CDD:275368	5/19 (26%)
		zf-H2C2_2	337..361	CDD:290200	9/23 (39%)
		C2H2 Zn finger	352..373	CDD:275368	6/20 (30%)
		C2H2 Zn finger	381..401	CDD:275368	8/19 (42%)
		zf-H2C2_2	394..415	CDD:290200	12/20 (60%)
		C2H2 Zn finger	409..429	CDD:275368	5/19 (26%)
		zf-H2C2_2	422..446	CDD:290200	12/25 (48%)
		C2H2 Zn finger	437..457	CDD:275368	8/21 (38%)
		C2H2 Zn finger	467..485	CDD:275368	0/17 (0%)
		C2H2 Zn finger	496..516	CDD:275370	5/19 (26%)
		C2H2 Zn finger	524..544	CDD:275368	3/19 (16%)
		zf-H2C2_2	536..561	CDD:290200	6/24 (25%)
		C2H2 Zn finger	552..573	CDD:275368	2/36 (6%)
		zf-C2H2	587..609	CDD:278523	3/32 (9%)
		C2H2 Zn finger	589..609	CDD:275368	2/19 (11%)
Kr-h1	NP_477466.1	C2H2 Zn finger	196..216	CDD:275368	6/19 (32%)
		COG5048	<270..420	CDD:227381	59/181 (33%)
		zf-C2H2	271..293	CDD:278523	5/21 (24%)
		C2H2 Zn finger	273..293	CDD:275368	5/19 (26%)
		zf-H2C2_2	286..309	CDD:290200	8/22 (36%)
		C2H2 Zn finger	301..321	CDD:275368	6/20 (30%)
		zf-H2C2_2	313..338	CDD:290200	12/25 (48%)
		C2H2 Zn finger	329..349	CDD:275368	8/19 (42%)
		zf-H2C2_2	344..366	CDD:290200	11/21 (52%)
		C2H2 Zn finger	357..377	CDD:275368	5/19 (26%)
		zf-H2C2_2	370..396	CDD:290200	12/25 (48%)
		C2H2 Zn finger	385..407	CDD:275368	8/52 (15%)
		zf-H2C2_2	400..424	CDD:290200	8/54 (15%)
		C2H2 Zn finger	415..435	CDD:275368	5/19 (26%)
		zf-C2H2	441..463	CDD:278523	4/21 (19%)
		C2H2 Zn finger	443..463	CDD:275368	3/19 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24390
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010