DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CTCF and Zfp629

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	XP_006508015.1	Gene:	Zfp629 / 320683	MGIID:	2444524	Length:	976	Species:	Mus musculus

Alignment Length:	547	Identity:	156/547 - (28%)
Similarity:	228/547 - (41%)	Gaps:	91/547 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 KELQKKLKQAAAKPGKATRSVVSTATNKSINL-RPAKSTPKATTSKPPPEPKAISVRPARAAAAK 166
            :|.|.:..:.|.. |....|....::.:.|.| .||:|          ||.|..|..|..:.:
Mouse   125 EESQNEAHRGAGS-GNEEESPQQESSGEEIILGDPAQS----------PESKDPSEMPLESPS-- 176

  Fly   167 AKQSAMPPPPALVVKVPAPRGRPRKNPVIPKPEPMDLERELEELVDEPDISSMVTELSDYTVDEA 231
              |.|..|..:     |.|.|          ..|:|.:..:     :|....:|...|::|   .
Mouse   177 --QDASAPQDS-----PTPLG----------SSPLDHQTPM-----DPSAPEVVPSPSEWT---K 216

  Fly   232 AVEA--ATATLTP-NEAEVYEFEDNATTE-----DENADKKDVDFVLSNKEVKLKTASSTSQNSN 288
            |.|.  ...|||| |...|....:.:..|     ...|:|.    .:.|     :...|.||.|.
Mouse   217 ACETNWQWGTLTPWNSTPVVTASEPSLRELVQGRPSGAEKP----YICN-----ECGKSFSQWSK 272

  Fly   289 ASGHK--------YSCPHCPYTASKKFLITRHSRSHDVEPSFKCSICERSFRSNVGLQNHINTHM 345
            ...|:        .:|..|..:.::...:.:|.|:|..|..:||..|.:.|..:..|..|..||.
Mouse   273 LLRHQRIHTGERPNTCSECGKSFTQSSHLVQHQRTHTGEKPYKCPDCGKCFSWSSNLVQHQRTHT 337

  Fly   346 GNKPHKCKLCESAFTTSGELVRHTRYKHTKEKPHKCTECTYASVELTKLRRHMTCHTGERPYQCP 410
            |.||:||..||.|||.|..|::|.| .||.|||:||.||..|....:.|.:|...||||:||:||
Mouse   338 GEKPYKCTECEKAFTQSTNLIKHQR-SHTGEKPYKCGECRRAFYRSSDLIQHQATHTGEKPYKCP 401

  Fly   411 HCTYASQDMFKLKRHMVIHTGEKKYQCDICKSRFTQSNSLKAHKLIHSVVDKPVFQCNYCPTTCG 475
            .|.........|.:|..||.|||.|:|..|...|.||:.|..|:..|: .:|| ::|..|..:.|
Mouse   402 ECGKRFGQNHNLLKHQKIHAGEKPYRCTECGKSFIQSSELTQHQRTHT-GEKP-YECLECGKSFG 464

  Fly   476 RKADLRVHIKHM--HTSDVPMTCRRCGQQLPDRYQYKLHVKSHEGEKCYSCKLCSYASVTQRHLA 538
            ..:.|   |||.  |..:.|..|..||:..........|.::|.||:.|.|..|..:.....:|.
Mouse   465 HSSTL---IKHQRTHLREDPFKCPVCGKTFTLSATLLRHQRTHTGERPYKCPECGKSFSVSSNLI 526

  Fly   539 SHMLIHLDEKPFHCDQCPQAFRQRQLLRRHMNL-------------------VHNEEYQPPEPRE 584
            :|..||..|:|:.|..|.::|.....|.||..:                   .|..:::.....|
Mouse   527 NHQRIHRGERPYICADCGKSFIMSSTLIRHQRIHTGEKPYKCSDCGKSFIRSSHLIQHRRTHTGE 591

  Fly   585 KLHKCPSCPREFTHKGNLMRHMETHDD 611
            |.:|||.|.:.|:...||:.|:.||.|
Mouse   592 KPYKCPECGKSFSQSSNLITHVRTHMD 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226	20/90 (22%)
		C2H2 Zn finger	296..316	CDD:275368	4/19 (21%)
		COG5048	321..>621	CDD:227381	106/312 (34%)
		zf-C2H2	322..344	CDD:278523	6/21 (29%)
		C2H2 Zn finger	324..344	CDD:275368	5/19 (26%)
		zf-H2C2_2	337..361	CDD:290200	13/23 (57%)
		C2H2 Zn finger	352..373	CDD:275368	10/20 (50%)
		C2H2 Zn finger	381..401	CDD:275368	6/19 (32%)
		zf-H2C2_2	394..415	CDD:290200	11/20 (55%)
		C2H2 Zn finger	409..429	CDD:275368	5/19 (26%)
		zf-H2C2_2	422..446	CDD:290200	11/23 (48%)
		C2H2 Zn finger	437..457	CDD:275368	7/19 (37%)
		C2H2 Zn finger	467..485	CDD:275368	4/17 (24%)
		C2H2 Zn finger	496..516	CDD:275370	4/19 (21%)
		C2H2 Zn finger	524..544	CDD:275368	4/19 (21%)
		zf-H2C2_2	536..561	CDD:290200	9/24 (38%)
		C2H2 Zn finger	552..573	CDD:275368	6/39 (15%)
		zf-C2H2	587..609	CDD:278523	8/21 (38%)
		C2H2 Zn finger	589..609	CDD:275368	7/19 (37%)
Zfp629	XP_006508015.1	PHA03169	<118..>269	CDD:223003	40/190 (21%)
		COG5048	251..629	CDD:227381	120/383 (31%)
		C2H2 Zn finger	260..280	CDD:275368	6/24 (25%)
		C2H2 Zn finger	288..308	CDD:275368	4/19 (21%)
		C2H2 Zn finger	316..336	CDD:275368	5/19 (26%)
		C2H2 Zn finger	344..364	CDD:275368	10/20 (50%)
		C2H2 Zn finger	372..392	CDD:275368	6/19 (32%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	428..448	CDD:275368	7/19 (37%)
		C2H2 Zn finger	456..476	CDD:275368	7/22 (32%)
		C2H2 Zn finger	484..504	CDD:275368	4/19 (21%)
		C2H2 Zn finger	512..532	CDD:275368	4/19 (21%)
		C2H2 Zn finger	540..560	CDD:275368	6/19 (32%)
		C2H2 Zn finger	568..588	CDD:275368	1/19 (5%)
		C2H2 Zn finger	596..616	CDD:275368	7/19 (37%)
		C2H2 Zn finger	624..644	CDD:275368
		C2H2 Zn finger	679..699	CDD:275368
		C2H2 Zn finger	772..792	CDD:275368
		C2H2 Zn finger	824..844	CDD:275368
		C2H2 Zn finger	877..897	CDD:275368
		C2H2 Zn finger	951..971	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910