DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CTCF and Zfp629

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_001101021.2	Gene:	Zfp629 / 308998	RGDID:	1306257	Length:	866	Species:	Rattus norvegicus

Alignment Length:	534	Identity:	154/534 - (28%)
Similarity:	224/534 - (41%)	Gaps:	87/534 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 AKPGKATRSVVSTATNKSINL-RPAKSTPKATTSKPPPEPKAISVRPARAAAAKAKQSAMPPPPA 177
            |:.|....|....::.:.|.| .||:|          ||.|..|..|..:.:    |.|..|..:
  Rat    26 AESGNEEESPQQESSGEEIILGDPAQS----------PESKDPSEMPLESPS----QDASAPQDS 76

  Fly   178 LVVKVPAPRGRPRKNPVIPKPEPMDLERELEELVDEPDISSMVTELSDYTVDEAAVEAATATL-- 240
                 |.|.|   .:..:....|||           |....:|...|::| .|.:.:..|.|.
  Rat    77 -----PTPLG---SSSSLDHQTPMD-----------PSAPEVVPSPSEWT-KETSWQWGTFTTWN 121

  Fly   241 -TPNEAEVYEFEDNATTEDENADKKDVDFVLSNKE---VKLKTASSTSQNSNASGHK-------- 293
             ||           |.|..|.:.::.|....|..|   :..:...|.||.|....|:
  Rat   122 STP-----------AVTASEPSLRELVQGRPSGAEKPYICNECGKSFSQWSKLLRHQRIHTGERP 175

  Fly   294 YSCPHCPYTASKKFLITRHSRSHDVEPSFKCSICERSFRSNVGLQNHINTHMGNKPHKCKLCESA 358
            .:|..|..:.::...:.:|.|:|..|..:||..|.:.|..:..|..|..||.|.||:||..||.|
  Rat   176 NTCSECGKSFTQSSHLVQHQRTHTGEKPYKCPDCGKCFSWSSNLVQHQRTHTGEKPYKCTECEKA 240

  Fly   359 FTTSGELVRHTRYKHTKEKPHKCTECTYASVELTKLRRHMTCHTGERPYQCPHCTYASQDMFKLK 423
            ||.|..|::|.| .||.|||:||.||..|....:.|.:|...||||:||:||.|.........|.
  Rat   241 FTQSTNLIKHQR-SHTGEKPYKCGECRRAFYRSSDLIQHQATHTGEKPYKCPECGKRFGQNHNLL 304

  Fly   424 RHMVIHTGEKKYQCDICKSRFTQSNSLKAHKLIHSVVDKPVFQCNYCPTTCGRKADLRVHIKHM- 487
            :|..||.|||.|:|..|...|.||:.|..|:..|: .:|| ::|..|..:.|..:.|   |||.
  Rat   305 KHQKIHAGEKPYRCTECGKSFIQSSELTQHQRTHT-GEKP-YECLECGKSFGHSSTL---IKHQR 364

  Fly   488 -HTSDVPMTCRRCGQQLPDRYQYKLHVKSHEGEKCYSCKLCSYASVTQRHLASHMLIHLDEKPFH 551
             |..:.|..|..||:..........|.::|.||:.|.|..|..:.....:|.:|..||..|:|:.
  Rat   365 THLREDPFKCPVCGKTFTLSATLLRHQRTHTGERPYKCPECGKSFSVSSNLINHQRIHRGERPYI 429

  Fly   552 CDQCPQAFRQRQLLRRHMNL-------------------VHNEEYQPPEPREKLHKCPSCPREFT 597
            |..|.::|.....|.||..:                   .|..:::.....||.:|||.|.:.|:
  Rat   430 CADCGKSFIMSSTLIRHQRIHTGEKPYKCSDCGKSFIRSSHLIQHRRTHTGEKPYKCPECGKSFS 494

  Fly   598 HKGNLMRHMETHDD 611
            ...||:.|:.||.|
  Rat   495 QSSNLITHVRTHMD 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226	21/90 (23%)
		C2H2 Zn finger	296..316	CDD:275368	4/19 (21%)
		COG5048	321..>621	CDD:227381	106/312 (34%)
		zf-C2H2	322..344	CDD:278523	6/21 (29%)
		C2H2 Zn finger	324..344	CDD:275368	5/19 (26%)
		zf-H2C2_2	337..361	CDD:290200	13/23 (57%)
		C2H2 Zn finger	352..373	CDD:275368	10/20 (50%)
		C2H2 Zn finger	381..401	CDD:275368	6/19 (32%)
		zf-H2C2_2	394..415	CDD:290200	11/20 (55%)
		C2H2 Zn finger	409..429	CDD:275368	5/19 (26%)
		zf-H2C2_2	422..446	CDD:290200	11/23 (48%)
		C2H2 Zn finger	437..457	CDD:275368	7/19 (37%)
		C2H2 Zn finger	467..485	CDD:275368	4/17 (24%)
		C2H2 Zn finger	496..516	CDD:275370	4/19 (21%)
		C2H2 Zn finger	524..544	CDD:275368	4/19 (21%)
		zf-H2C2_2	536..561	CDD:290200	9/24 (38%)
		C2H2 Zn finger	552..573	CDD:275368	6/39 (15%)
		zf-C2H2	587..609	CDD:278523	8/21 (38%)
		C2H2 Zn finger	589..609	CDD:275368	7/19 (37%)
Zfp629	NP_001101021.2	fibronec_FbpA	<26..>147	CDD:411474	37/165 (22%)
		zf-C2H2	148..170	CDD:395048	5/21 (24%)
		C2H2 Zn finger	150..170	CDD:275368	5/19 (26%)
		zf-C2H2	177..198	CDD:395048	4/20 (20%)
		C2H2 Zn finger	178..198	CDD:275368	4/19 (21%)
		COG5048	202..510	CDD:227381	106/313 (34%)
		C2H2 Zn finger	206..226	CDD:275368	5/19 (26%)
		C2H2 Zn finger	234..254	CDD:275368	10/20 (50%)
		C2H2 Zn finger	262..282	CDD:275368	6/19 (32%)
		C2H2 Zn finger	290..310	CDD:275368	5/19 (26%)
		C2H2 Zn finger	318..338	CDD:275368	7/19 (37%)
		C2H2 Zn finger	346..366	CDD:275368	7/22 (32%)
		C2H2 Zn finger	374..394	CDD:275368	4/19 (21%)
		C2H2 Zn finger	402..422	CDD:275368	4/19 (21%)
		C2H2 Zn finger	430..450	CDD:275368	6/19 (32%)
		C2H2 Zn finger	458..478	CDD:275368	1/19 (5%)
		C2H2 Zn finger	486..506	CDD:275368	7/19 (37%)
		C2H2 Zn finger	514..534	CDD:275368
		C2H2 Zn finger	569..589	CDD:275368
		C2H2 Zn finger	662..682	CDD:275368
		C2H2 Zn finger	714..734	CDD:275368
		C2H2 Zn finger	767..787	CDD:275368
		C2H2 Zn finger	841..861	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000