DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CTCF and Zfp574

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	XP_038967305.1	Gene:	Zfp574 / 308434	RGDID:	1311420	Length:	909	Species:	Rattus norvegicus

Alignment Length:	756	Identity:	161/756 - (21%)
Similarity:	239/756 - (31%)	Gaps:	264/756 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 PMEEAEADLDHA-EEAEEEEEDDEDKYFIDDEGNCYIKTTPKKQKELQKKLKQAAAKPGKATRSV 123
            |:.:|...::|: .:|||..|                                .||.|..|..:.
  Rat   182 PVGQARVAVEHSYRKAEEGGE--------------------------------GAAVPSVAAATE 214

  Fly   124 VSTATN---------KSINLRPAKSTPKATTSKPPPEPKAISVRPARAAAAKAKQSAMPPPPALV 179
            :.|...         ..:...||.......|..|.|.|:|       ...|..:::.:|.|....
  Rat   215 MVTEVELLLYKCSECSQLFQMPADFLEHQATHFPAPVPEA-------EEPATQQETLVPSPTEAA 272

  Fly   180 VKVPAP-------------------RGRPRKNPVIPKP------------------------EPM 201
            |..|.|                   .||.|:.   .||                        .|.
  Rat   273 VSQPDPLPASDHSYELRNELRNGEAMGRDRRG---RKPRRSSSGESGATQELFCSACDQIFLSPH 334

  Fly   202 DLERELEELVDE-----------PDISSMVTELSDYT-------VD-------EAAVEAATATLT 241
            .|::.|....:.           |..||:...|.|::       ||       ||.:.|.....|
  Rat   335 QLQQHLRSHREGVFKCPLCSRVFPSPSSLDQHLGDHSSESHFLCVDCGLAFGTEALLLAHRRAHT 399

  Fly   242 PN--------------------------------------EAEVYEFEDNATTEDENADKKDVDF 268
            ||                                      |.....|.:.|..|....:..:
  Rat   400 PNPLHSCPCGKTFVNLTKFLYHRRTHGAGGVPLPTTPVPPEEPAISFPEPAPAETGELEAPE--- 461

  Fly   269 VLSNKEVKLKTASSTSQNSNASGHKYSCPHCPYTASKKFLITRHSR-SHDVEPSFKCSICERSFR 332
                    |..:..:|....|.| .|.|..|....||...:|||.| .|.:|...|||||.:.|:
  Rat   462 --------LPVSEESSAEPAAPG-TYRCLLCSREFSKALQLTRHQRFVHRLERRHKCSICGKMFK 517

  Fly   333 SNVGLQNHINTHMGNKPHKCKLCESAFTTSGELVRHTRYKHTKEKPHKCTECTYASVELTKLRRH 397
            ....::||:.||.|.:|..|..|...|.:...|.|| |..||.|:|::|.:|..|..:.:.||:|
  Rat   518 KKSHVRNHLRTHTGERPFPCPDCSKPFNSPANLARH-RLTHTGERPYRCGDCGKAFTQSSTLRQH 581

  Fly   398 ------------MTC----------------HTGERPYQCPHCTYASQDMFKLKR-----HMVIH 429
                        ..|                ||||.||:|..|..:    |.|:|     .:|:|
  Rat   582 RLVHAQHFPYRCQECGVRFHRPYRLLMHRYHHTGEYPYKCRECPRS----FLLRRLLEVHQLVVH 642

  Fly   430 TGEKKYQCDICKSRFTQSNSLKAHKLIHSVVDKP-VFQCNYCPTTCGRKADLRVHIKHMH----- 488
            .|.:.::|..|.:.|..|..|:.|:...:....| .|:|..|....|..|.|:.| :..|
  Rat   643 AGRQPHRCPSCGAAFPSSLRLREHRCAAAAAQAPRRFECGTCGKKVGSAARLQAH-EAAHAAAGP 706

  Fly   489 -------------------------------TSDVP--------MTCRRCGQQLPDRYQYKLHVK 514
                                           ||..|        :.|..|.:........::|.:
  Rat   707 GEVLAKEPPAPRAARATRTPVAPSPTALGGTTSAAPAAPARRRGLECSECKKLFSTETSLQVHRR 771

  Fly   515 SHEGEKCYSCKLCSYASVTQRHLASHMLIHLDEKPFHCDQCPQAFRQRQLLRRHMNLVHNEEYQP 579
            .|.||:.|.|..|..|.....||..|..:|..|:||.|:.|.:||.....|..|.. :|.
  Rat   772 IHTGERPYPCPDCGKAFRQSTHLKDHRRLHTGERPFACEVCGKAFAISMRLAEHRR-IHT----- 830

  Fly   580 PEPREKLHKCPSCPREFTHKGNLMRHMETHDDSANAREKRR 620
               .|:.:.||.|.:.:....||.:|.:||.....|..:::
  Rat   831 ---GERPYSCPDCGKSYRSFSNLWKHRKTHQQQHQAAVRQQ 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226	23/141 (16%)
		C2H2 Zn finger	296..316	CDD:275368	8/20 (40%)
		COG5048	321..>621	CDD:227381	96/378 (25%)
		zf-C2H2	322..344	CDD:278523	8/21 (38%)
		C2H2 Zn finger	324..344	CDD:275368	7/19 (37%)
		zf-H2C2_2	337..361	CDD:290200	9/23 (39%)
		C2H2 Zn finger	352..373	CDD:275368	7/20 (35%)
		C2H2 Zn finger	381..401	CDD:275368	7/47 (15%)
		zf-H2C2_2	394..415	CDD:290200	12/48 (25%)
		C2H2 Zn finger	409..429	CDD:275368	6/24 (25%)
		zf-H2C2_2	422..446	CDD:290200	8/28 (29%)
		C2H2 Zn finger	437..457	CDD:275368	6/19 (32%)
		C2H2 Zn finger	467..485	CDD:275368	6/17 (35%)
		C2H2 Zn finger	496..516	CDD:275370	3/19 (16%)
		C2H2 Zn finger	524..544	CDD:275368	6/19 (32%)
		zf-H2C2_2	536..561	CDD:290200	11/24 (46%)
		C2H2 Zn finger	552..573	CDD:275368	6/20 (30%)
		zf-C2H2	587..609	CDD:278523	6/21 (29%)
		C2H2 Zn finger	589..609	CDD:275368	6/19 (32%)
Zfp574	XP_038967305.1	zf-C2H2_8	323..402	CDD:406359	15/78 (19%)
		C2H2 Zn finger	323..343	CDD:275368	3/19 (16%)
		C2H2 Zn finger	350..370	CDD:275368	4/19 (21%)
		C2H2 Zn finger	378..398	CDD:275368	5/19 (26%)
		C2H2 Zn finger	406..425	CDD:275368	0/18 (0%)
		lambda-1	469..>503	CDD:212564	13/34 (38%)
		C2H2 Zn finger	480..501	CDD:275368	8/20 (40%)
		COG5048	507..861	CDD:227381	95/368 (26%)
		C2H2 Zn finger	509..529	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	7/20 (35%)
		C2H2 Zn finger	565..585	CDD:275368	6/19 (32%)
		C2H2 Zn finger	593..613	CDD:275368	1/19 (5%)
		C2H2 Zn finger	621..642	CDD:275368	6/24 (25%)
		C2H2 Zn finger	650..667	CDD:275368	5/16 (31%)
		C2H2 Zn finger	753..773	CDD:275368	3/19 (16%)
		C2H2 Zn finger	781..801	CDD:275368	6/19 (32%)
		C2H2 Zn finger	809..829	CDD:275368	6/20 (30%)
		C2H2 Zn finger	837..857	CDD:275368	6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000