DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CTCF and Zfp612

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_001100898.2	Gene:	Zfp612 / 307839	RGDID:	1307197	Length:	675	Species:	Rattus norvegicus

Alignment Length:	472	Identity:	140/472 - (29%)
Similarity:	198/472 - (41%)	Gaps:	91/472 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 VPAPRGRPRKNPV---IPKPEPMDLERELEELVDEPDISSMVTELSDYTVDEAAVEAATATLTP- 242
            |.|..||.:.:||   :|.|.|.         :.:...||...:.||..:.:.  |..||..||
  Rat   147 VSASNGRAKTSPVEGHLPSPMPH---------LSQDHASSAGEQYSDTKLTKN--EKITAQETPL 200

  Fly   243 NEAEVYEFEDNATTEDENADKKDVDFVLSNKEVKLKTASSTSQNSNASGHKYSCPHCPYTASKKF 307
            ...|:.|....::..::..:..||:                        ..|.|..|....|.|.
  Rat   201 KHKELAEASQGSSQVNQLPESCDVE------------------------KPYQCTECGKAFSVKA 241

  Fly   308 LITRHSRSHDVEPSFKCSICERSFRSNVGLQNHINTHMGNKPHKCKLCESAFTTSGELVRHTRYK 372
            ....|.|.|:.|..|||..|.:.|..:.....|...|.|.||::||:|..||:.:|.||||.|.
  Rat   242 KFVWHQRLHNGEKPFKCVECGKCFSYSSHYITHQTIHSGEKPYQCKVCGKAFSVNGSLVRHQRI- 305

  Fly   373 HTKEKPHKCTEC----TYASVELTKLRRHMTCHTGERPYQCPHCTYASQDMFKLKRHMVIHTGEK 433
            ||.|||::|.||    ..:|..:|    |...||||:||:|..|..|.....||.:|..||||||
  Rat   306 HTGEKPYQCKECGTGFGCSSAYIT----HQRTHTGEKPYECSDCGKAFNVNAKLIQHQRIHTGEK 366

  Fly   434 KYQCDICKSRFTQSNSLKAHKLIHS---------------------------VVDKPVFQCNYCP 471
            .|:||:|...|..|..|:.|:.||:                           ..:|| :.|:.|.
  Rat   367 PYECDVCGKGFRCSTQLRQHQSIHTGEKPHRCSECGKGFTKNAKLIQHQRVHTGEKP-YACSDCG 430

  Fly   472 TTCGRKADLRVHIKHMHTSDVPMTCRRCGQQLPDRYQYKLHVKSHEGEKCYSCKLCSYASVTQRH 536
            .|...|..|..| :.:||.:.|..|..||:......|.:.|::.|.|||.|.|..|..|......
  Rat   431 KTFSAKGKLIQH-QRIHTGERPYECSECGKSFRCNSQLRQHLRIHTGEKPYKCNECGKAFNVNAK 494

  Fly   537 LASHMLIHLDEKPFHCDQCPQAFRQRQLLRRHMNLVHNEEYQPPEPREKLHKCPSCPREFTHKGN 601
            |..|...|..||||.|::|.:.|..::      ||:   ::|.....||.::|..|.:.|:....
  Rat   495 LMQHRRTHTGEKPFECNECGKCFTSKR------NLL---DHQRTHTGEKPYQCKECGKAFSINAK 550

  Fly   602 LMRHMETHDDSANAREK 618
            |.||.:.|     .|||
  Rat   551 LTRHQQIH-----TREK 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226	9/26 (35%)
		C2H2 Zn finger	296..316	CDD:275368	6/19 (32%)
		COG5048	321..>621	CDD:227381	109/329 (33%)
		zf-C2H2	322..344	CDD:278523	6/21 (29%)
		C2H2 Zn finger	324..344	CDD:275368	4/19 (21%)
		zf-H2C2_2	337..361	CDD:290200	10/23 (43%)
		C2H2 Zn finger	352..373	CDD:275368	11/20 (55%)
		C2H2 Zn finger	381..401	CDD:275368	6/23 (26%)
		zf-H2C2_2	394..415	CDD:290200	9/20 (45%)
		C2H2 Zn finger	409..429	CDD:275368	6/19 (32%)
		zf-H2C2_2	422..446	CDD:290200	13/23 (57%)
		C2H2 Zn finger	437..457	CDD:275368	7/19 (37%)
		C2H2 Zn finger	467..485	CDD:275368	6/17 (35%)
		C2H2 Zn finger	496..516	CDD:275370	5/19 (26%)
		C2H2 Zn finger	524..544	CDD:275368	5/19 (26%)
		zf-H2C2_2	536..561	CDD:290200	10/24 (42%)
		C2H2 Zn finger	552..573	CDD:275368	5/20 (25%)
		zf-C2H2	587..609	CDD:278523	6/21 (29%)
		C2H2 Zn finger	589..609	CDD:275368	6/19 (32%)
Zfp612	NP_001100898.2	KRAB	14..74	CDD:214630
		C2H2 Zn finger	230..250	CDD:275368	6/19 (32%)
		COG5048	254..660	CDD:227381	109/330 (33%)
		C2H2 Zn finger	258..278	CDD:275368	4/19 (21%)
		C2H2 Zn finger	286..306	CDD:275368	11/20 (55%)
		C2H2 Zn finger	314..334	CDD:275368	6/23 (26%)
		C2H2 Zn finger	342..362	CDD:275368	6/19 (32%)
		C2H2 Zn finger	370..390	CDD:275368	7/19 (37%)
		C2H2 Zn finger	398..418	CDD:275368	0/19 (0%)
		C2H2 Zn finger	426..446	CDD:275368	6/20 (30%)
		C2H2 Zn finger	454..474	CDD:275368	5/19 (26%)
		C2H2 Zn finger	482..502	CDD:275368	5/19 (26%)
		C2H2 Zn finger	510..530	CDD:275368	6/28 (21%)
		C2H2 Zn finger	538..558	CDD:275368	6/19 (32%)
		C2H2 Zn finger	566..586	CDD:275368
		C2H2 Zn finger	594..614	CDD:275368
		C2H2 Zn finger	622..642	CDD:275368
		C2H2 Zn finger	650..670	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000