DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CTCF and Zfp35

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_001013159.1	Gene:	Zfp35 / 307547	RGDID:	1312031	Length:	580	Species:	Rattus norvegicus

Alignment Length:	414	Identity:	128/414 - (30%)
Similarity:	189/414 - (45%)	Gaps:	49/414 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   223 LSDYTVDEAAVEAATATLTPNEAEVYEFEDNATTEDENADKKDVDFVLSNKEVKLKTASSTSQNS 287
            |||..|.....|.||......|.|....|..::..|:..:.|...|.....|:..:......|
  Rat    15 LSDGEVQIKIGEPATEEEMTGEIETLTEESGSSQADDAHNSKGSGFFEFGDELNDQMLFGRRQ-- 77

  Fly   288 NASGHKYSCPHCPYTASKKFLITRHSRSHDVEPSFKCSICERSFRSNVGLQNHINTHMGNKPHKC 352
                  |:|..|..:.:....:.||.|:| .:| ::|..|.::||.:..|..|...|.|.||:.|
  Rat    78 ------YNCDECGQSFAWNTGLIRHQRTH-WKP-YECEECGKAFRMSSALVLHQRIHTGEKPYPC 134

  Fly   353 KLCESAFTTSGELVRHTRYKHTKEKPHKCTECTYASVELTKLRRHMTCHTGERPYQCPHCTYASQ 417
            ..|..:|:.|.:|::|.|. ||.|||:||.||..|..:.:.|..|...||||:||||.||:.:..
  Rat   135 SWCIKSFSRSSDLIKHQRV-HTGEKPYKCDECGKAFSQSSDLMTHQRIHTGEKPYQCSHCSKSFS 198

  Fly   418 DMFKLKRHMVIHTGEKKYQCDICKSRFTQSNSLKAHKLIHSVVDKPVFQCNYCPTTCGRKAD--- 479
            ....:.:|:.||||||.|.|:.|...|:||:.|..|:.||: .:|| ::|:.|.....:.:|
  Rat   199 QHSGMVKHLRIHTGEKPYMCNHCYKHFSQSSDLIKHERIHT-GEKP-YKCDVCGKAFSQSSDRIL 261

  Fly   480 -LRVH---------------------IKH--MHTSDVPMTCRRCGQQLPDRYQYKLHVKSHEGEK 520
             .|:|                     |||  :||.:.|..|..||:.........||.:.|.|||
  Rat   262 HQRIHTGEKPYPCAQCNKSFSQNSDLIKHRRIHTGEKPYQCSECGKAFNQSSVLILHQRIHTGEK 326

  Fly   521 CYSCKLCSYASVTQRHLASHMLIHLDEKPFHCDQCPQAFRQRQLLRRHMNLVHNEEYQPPEPREK 585
            .|.|..|:.:......|.:|..||..|||:.|.||.:.|.:|..|.:|.. :|.        .||
  Rat   327 PYPCNQCAKSFSRLSDLINHQRIHTGEKPYPCSQCSKMFSRRSDLVKHYR-IHT--------GEK 382

  Fly   586 LHKCPSCPREFTHKGNLMRHMETH 609
            .::|..|.:.|:...||:.|...|
  Rat   383 PYECDKCGKTFSQSSNLILHQRIH 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226
		C2H2 Zn finger	296..316	CDD:275368	5/19 (26%)
		COG5048	321..>621	CDD:227381	105/316 (33%)
		zf-C2H2	322..344	CDD:278523	6/21 (29%)
		C2H2 Zn finger	324..344	CDD:275368	6/19 (32%)
		zf-H2C2_2	337..361	CDD:290200	9/23 (39%)
		C2H2 Zn finger	352..373	CDD:275368	7/20 (35%)
		C2H2 Zn finger	381..401	CDD:275368	6/19 (32%)
		zf-H2C2_2	394..415	CDD:290200	12/20 (60%)
		C2H2 Zn finger	409..429	CDD:275368	4/19 (21%)
		zf-H2C2_2	422..446	CDD:290200	11/23 (48%)
		C2H2 Zn finger	437..457	CDD:275368	7/19 (37%)
		C2H2 Zn finger	467..485	CDD:275368	5/42 (12%)
		C2H2 Zn finger	496..516	CDD:275370	5/19 (26%)
		C2H2 Zn finger	524..544	CDD:275368	4/19 (21%)
		zf-H2C2_2	536..561	CDD:290200	11/24 (46%)
		C2H2 Zn finger	552..573	CDD:275368	7/20 (35%)
		zf-C2H2	587..609	CDD:278523	6/21 (29%)
		C2H2 Zn finger	589..609	CDD:275368	6/19 (32%)
Zfp35	NP_001013159.1	C2H2 Zn finger	80..100	CDD:275368	5/19 (26%)
		COG5048	102..486	CDD:227381	106/318 (33%)
		C2H2 Zn finger	106..126	CDD:275368	6/19 (32%)
		C2H2 Zn finger	134..154	CDD:275368	7/20 (35%)
		zf-H2C2_2	146..171	CDD:290200	13/25 (52%)
		C2H2 Zn finger	162..182	CDD:275368	6/19 (32%)
		zf-H2C2_2	174..199	CDD:290200	12/24 (50%)
		C2H2 Zn finger	190..210	CDD:275368	4/19 (21%)
		C2H2 Zn finger	218..238	CDD:275368	7/19 (37%)
		zf-H2C2_2	230..255	CDD:290200	8/26 (31%)
		C2H2 Zn finger	246..266	CDD:275368	4/19 (21%)
		zf-H2C2_2	262..283	CDD:290200	2/20 (10%)
		C2H2 Zn finger	274..294	CDD:275368	3/19 (16%)
		zf-H2C2_2	286..311	CDD:290200	9/24 (38%)
		C2H2 Zn finger	302..322	CDD:275368	5/19 (26%)
		zf-H2C2_2	318..339	CDD:290200	8/20 (40%)
		C2H2 Zn finger	330..350	CDD:275368	4/19 (21%)
		zf-H2C2_2	342..367	CDD:290200	11/24 (46%)
		C2H2 Zn finger	358..378	CDD:275368	7/20 (35%)
		zf-H2C2_2	370..395	CDD:290200	8/33 (24%)
		C2H2 Zn finger	386..406	CDD:275368	6/19 (32%)
		zf-H2C2_2	398..423	CDD:290200	4/9 (44%)
		C2H2 Zn finger	414..434	CDD:275368
		zf-H2C2_2	426..451	CDD:290200
		C2H2 Zn finger	442..462	CDD:275368
		zf-H2C2_2	454..479	CDD:290200
		C2H2 Zn finger	470..490	CDD:275368
		C2H2 Zn finger	498..518	CDD:275368
		C2H2 Zn finger	526..545	CDD:275368
		zf-H2C2_2	541..562	CDD:290200
		C2H2 Zn finger	553..573	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000